Ganoderma boninense mycelia for phytochemicals and secondary metabolites with antibacterial activity

Abdullah, Syahriel; Jang, Se-Eun; Kwak, Min-Kyu; Chong, Khim Phin

doi:10.1007/s12275-020-0208-z

Cited by 9 publications

(5 citation statements)

References 39 publications

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“…It was observed that the methanol extract produced maximum extraction yield. This is in line with Abdullah et al [ 23 ] who reported previously that methanol extract of different plants usually yields significantly higher amounts compared to chloroform and hexane extract of same plants and it was further explained that it may be owing to occurrence of functional particles which are mostly polar organic phytochemical and are always available in most medicinal plants. For most studies, crude fibre, protein and good energy are considered as the main determinants of food types, and very few studies are available on the elemental composition of the Diospyros edible species.…”

Section: Discussionsupporting

confidence: 90%

Cytotoxic Potential of Diospyros villosa Leaves and Stem Bark Extracts and Their Silver Nanoparticles

Adu

Naidoo

Lin

et al. 2023

Plants

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Diospyros villosa is traditionally used for an anti-bacterial property. Its cytotoxic effects have not been studied before. Therefore, this study aimed to examine the nutritional properties as well the cytotoxic effects of D. villosa. The leaves and stem barks were subjected to three different extraction methods (methanol, chloroform and hexane) and their nanoparticles were synthesized at two different temperatures (room temperature and at 80 °C). Thereafter, extracts were assessed using the associated AOCC protocols, for their nutritional content (moisture, fibre, proteins, lipid, ash and hydrolysable carbohydrates). Diospyros villosa extracts and their corresponding nanoparticles were then incubated overnight with cancerous and noncancerous cell lines to evaluate their cytotoxic potential. The nutritional analysis revealed that both young and mature leaves were rich sources of protein having values of 14.95% and 11.37% respectively. The moisture content was observed to be higher in all the leaf types (8.54 ± 0.75%, 9.67 ± 0.98% and 7.40 ± 0.80%) compared to the stem (2.13 ± 0.07%) respectively. The MTT cytotoxicity assay showed that the cell viability of MCF-7 cell lines was significantly lower when exposed to hexane and chloroform leaves extracts of D. villosa (IC50 of 26.64 and 26.07 µg mL−1) respectively, compared to camptothecin (36.54 µg mL−1). Similarly, the MCF-7 cell viability was observed to be significantly lower when exposed to hexane and chloroform stem extracts of D. villosa (IC50 of 24.57 and 3.92 µg mL−1), compared to camptothecin (36.54 µg mL−1). The cell viability of A549 cell lines was also found lower when exposed to the hexane and chloroform extracts (IC50 of 7.76 and 4.59 µg mL−1) compared to camptothecin (IC50 of 19.26 µg mL−1). Furthermore, the viability of A549 cell lines was found lower when exposed to hexane and chloroform stem extracts of D. villosa (IC50 of 10.67 and 5.35 µg mL−1) compared to camptothecin (19.26 µg mL−1). The biosynthesized nanoparticles further displayed an anticancer activity with an IC50 value of 4.08 µg mL−1 when compared to the control (36.54 µg mL−1). However, the HEK293 cell viability was observed to be significantly higher on exposure to hexane stem extracts of D. villosa (IC50 of 158.5 µg mL−1) compared to camptothecin (IC50 of 14.77 µg mL−1). Therefore, Diospyros villosa leaves, stem bark and nanoparticles synthesized showed high potential for being considered as a candidate for an anti-cancer regimen.

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Section: Discussionsupporting

confidence: 90%

Cytotoxic Potential of Diospyros villosa Leaves and Stem Bark Extracts and Their Silver Nanoparticles

Adu

Naidoo

Lin

et al. 2023

Plants

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“…Secondary metabolites, demonstrating a diverse set of properties in the plant (influencing its development, protection against the adverse effects of external factors, etc.) may also show an extremely important effect from the human point of view, such as anti‐cancer, anti‐bacterial or anti‐viral properties [36–41] . Since these compounds are synthesized in the course of numerous and often complex biochemical transformations, the possibility of modulation of these processes is the focus of many scientists.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models

Kowalczyk

Sitarek

Toma

et al. 2021

Chemistry & Biodiversity

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Betulinic acid, which is found in transgenic roots of Senna obtusifolia (L.) H.S.Irwin & Barneby, is a pentacyclic triterpene with distinctive pharmacological activities. In this study, we report the differences in the content of betulinic acid and selected anthraquinones in transgenic S. obtusifolia hairy roots with overexpression of the PgSS1 gene (SOPSS2 line) and in transformed hairy roots without this genetic construct (SOA41 line). Both hairy root lines grew in 10 L sprinkle bioreactor. Additionally, the extracts obtained from this plant material were used for biological tests. Our results demonstrated that the SOPSS2 hairy root cultures from the bioreactor showed an increase in the content of betulinic acid (38.125 mg/g DW), compared to the SOA41 hairy root line (4.213 mg/g DW). Biological studies have shown a cytotoxic and antiproliferative effect on U‐87MG glioblastoma cells, and altering the level of apoptotic proteins (Bax, p53, Puma and Noxa). Antimicrobial properties were demonstrated for both tested extracts, with a stronger effect of SOPSS2 extract. Moreover, both extracts showed moderate antiviral properties on norovirus surrogates.

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“…Ganocalidin A (14), from the fruiting bodies of G. capense , could increase LXRα and reduced lipid accumulation as an LXRα agonist ( Liao et al, 2019 ). Ganoboninone E (15) and ganoboninketals A-C (16–18), dominating compounds of the fruiting bodies of G. boninense , exhibited remarkable agonistic activity to the transactivation of LXRβ ( Ma et al, 2015 ; Abdullah et al, 2020 ). Tripterygium wilfordii Hook.…”

Section: Natural Products Targeting Liver X Receptorsmentioning

confidence: 99%

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor

She

Pang

et al. 2022

Front. Pharmacol.

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Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals. Among NRs, the liver X receptors (LXRs) and farnesoid X receptor (FXR) have been of significance as targets for the treatment of metabolic syndrome-related diseases. In recent years, natural products targeting LXRs and FXR have received remarkable interests as a valuable source of novel ligands encompassing diverse chemical structures and bioactive properties. This review aims to survey natural products, originating from terrestrial plants and microorganisms, marine organisms, and marine-derived microorganisms, which could influence LXRs and FXR. In the recent two decades (2000–2020), 261 natural products were discovered from natural resources such as LXRs/FXR modulators, 109 agonists and 38 antagonists targeting LXRs, and 72 agonists and 55 antagonists targeting FXR. The docking evaluation of desired natural products targeted LXRs/FXR is finally discussed. This comprehensive overview will provide a reference for future study of novel LXRs and FXR agonists and antagonists to target human diseases, and attract an increasing number of professional scholars majoring in pharmacy and biology with more in-depth discussion.

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Ganoderma boninense mycelia for phytochemicals and secondary metabolites with antibacterial activity

Cited by 9 publications

References 39 publications

Cytotoxic Potential of Diospyros villosa Leaves and Stem Bark Extracts and Their Silver Nanoparticles

Cytotoxic Potential of Diospyros villosa Leaves and Stem Bark Extracts and Their Silver Nanoparticles

Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor

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