Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway

High-Mobility Group Box 1 Overexpression Predicts a Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Gastric Cancer by Activating TLR4/NF-κB Signaling

“…Increasing evidence suggests that chronic infection and inflammation are the most important acquired and environmental factors that promote the occurrence and progression of tumors, and the TLR4/NF-κB pathway may play an important role in this process [41, 42]. Studies have shown that TLR4 activates the classical NF-κB pathway during bacterial or viral infections, which produces cytokines that promote the occurrence and development of tumors [43, 44]. Studies have also proposed that TLR4, as a promoter of the signaling pathway, can be stimulated by bacterial components and endogenous ligands to activate NF, thereby promoting tumor growth and resistance to chemotherapy drugs [45].…”

Current progress in the hypoglycemic mechanisms of natural polysaccharides

“…86 Numerous reports have found that several polysaccharides extracted from Gardenia jasminoides Ellis, Chrysanthemum morifolium Ramat, Polygonatum kingianum, Arctium lappa L., Paecilomyces hepialid, Ganoderma lucidum and guava block the NF-κB and/or MAPK signaling pathway in the liver, colon, kidneys or adipose tissue, further reducing the release of pro-inflammatory cytokines and improving insulin sensitivity. [24][25][26][87][88][89][90] Apart from pro-inflammatory cytokines and chemokines, adipokine imbalance also contributes to metabolic inflammation. 9 Although leptin can regulate lipid and energy metabolism, leptin is also considered as a proinflammatory adipokine.…”

“…Therefore, dietary intervention is a promising therapeutic approach to alleviate diet-induced metabolic diseases. Nowadays, natural polysaccharides have received increasing attention due to their hypoglycemic, [12][13][14][15] energyregulating, [16][17][18] antioxidant, [19][20][21][22] anti-inflammatory [23][24][25][26] and prebiotic effects. [27][28][29][30] Because of these functional properties, natural polysaccharides possess potential capacities to alleviate diet-induced type 2 diabetes mellitus.…”

N‐methyl‐D‐aspartic acid receptor 2A functionalized stationary phase: A reliable method for pursuing potential ligands against Alzheimer's disease from natural products

“…Gardenia jasminoides Ellis is an evergreen shrub that distributes in the tropical and subtropical areas of the world, the desiccative ripe fruits of which are widely used as not only a natural colorant in food products including confectioneries and noodles, but also a functional health food for making tea and cooking porridge 7 . In addition, previous studies demonstrated that the fruit of G. jasminoides Ellis possessed many beneficial properties and was broadly used for the prevention and treatment of various diseases, such as hypertension, 8 hepatic injury, 9 and metabolic disorders 10 . Notably, G. jasminoides Ellis extract was reported to alleviate cognitive deficits in both APP/PS1 transgenic mice 11 and Aβ‐induced mouse models 12 .…”