Gardening can seriously damage your health

Russell, Katherine E.; Broadbridge, Carl; Murray, Sebastian; Waghorn, David; Mahoney, Allan

doi:10.1016/s0140-6736(08)60877-6

Cited by 25 publications

(19 citation statements)

References 5 publications

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“…Toxicological studies showed that gliotoxin can exacebarate the pathogenesis of aspergillosis (Sutton and others 1996). A gardener developed a fatal aspergillosis and died after inhalation of decayed plant matter contaminated with A. fumigatus spores (Russel and others 2008). The chances are very high to get aspergillosis when the humans consume A. fumigatus ‐contaminated foods.…”

Section: Resultsmentioning

confidence: 99%

Occurrence of Aspergillus spp. and Aflatoxin B₁ in Malaysian Foods Used for Human Consumption

Reddy

Farhana

Salleh

2011

Journal of Food Science

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Malaysian population widely consumes the cereal-based foods, oilseeds, nuts, and spices in their daily diet. Mycotoxigenic fungi are well known to invade food products under storage conditions and produce mycotoxins that have threat to human and animal health. Therefore, determining toxigenic fungi and aflatoxin B(1) (AFB1) in foods used for human consumption is of prime importance to develop suitable management strategies and to minimize risk. Ninety-five food products marketed in Penang, Malaysia were randomly collected from different supermarkets and were analyzed for presence of Aspergillus spp. by agar plate assay and AFB1 by enzyme-linked immunosorbent assay (ELISA). A. flavus was the dominant fungi in all foods followed by A. niger. Fifty-five A. flavus strains were tested for their ability to produce aflatoxins on rice grain substrate. Thirty-six (65.4%) strains out of 55 produced AFB1 ranging from 1700 to 4400 μg/kg and 17 strains (31%) produced AFB2 ranging from 620 to 1670 μg/kg. Natural occurrence of AFB1 could be detected in 72.6% food products ranging from 0.54 to 15.33 μg/kg with a mean of 1.95 μg/kg. Maximum AFB1 levels were detected in peanut products ranging from 1.47 to 15.33 μg/kg. AFB1 levels detected in all food products were below the Malaysian permissible limits (<35 μg/kg). Aspergillus spp. and AFB1 was not detected in any cookies tested. Although this survey was not comprehensive, it provides valuable information on aflatoxin levels in foods marketed in Malaysia.

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Section: Resultsmentioning

confidence: 99%

Occurrence of Aspergillus spp. and Aflatoxin B₁ in Malaysian Foods Used for Human Consumption

Reddy

Farhana

Salleh

2011

Journal of Food Science

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“…One case was organic dust toxic syndrome (ODTS), one case was insufficiently characterized (hypersensitivity pneumonitis or ODTS), one case was external otitis from Aspergillus niger, and three were invasive aspergillosis (Bünger et al, 2007;Clark et al, 1984;Weber et al, 1993). The latter cases concerned a worker in a green-waste composting plant, a professional gardener that probably handled compost, and a welder who spread rotting tree and plant mulch from a sack around his garden (Russell et al, 2008;Vincken and Roels, 1984;Zuk et al, 1989). The three cases of invasive aspergillosis did not represent typical characteristics for individual risk factors because the patients were not known to be immuno-compromised.…”

Section: Resultsmentioning

confidence: 99%

Bioaerosol in Composting Facilities: Occupational Health Risk Assessment

Schlosser

Huyard²,

Cartnick³

et al. 2009

Water Environment Research

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This research found evidence of an association between occupational exposure to bioaerosols in composting plants and health outcome occurrence in exposed workers. An occupational exposure assessment in six composting plants was performed to better characterize personal exposure levels and evaluate associated health risk in workers. Sampling results showed large ranges of concentrations of dust, bacteria, molds, and endotoxin in ambient air and in personal samples, both when driving a front-end loader and when cleaning, monitoring, and performing maintenance tasks. Mean personal exposure levels were high at 100 to more than 10 000 times higher than outdoor background levels and fully consistent with occurrence of inflammatory and allergic respiratory outcomes among workers. Engineering control, personal protection, and education and training programs for employees, health, and safety officials, and occupational physicians are being developed and implemented. Water Environ. Res., 81, 866 (2009).

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“…This fungus causes different pathologies including occupational rhinitis in people working in damp and mouldy places [6], allergic aspergillosis and invasive forms of aspergillosis in immunosuppressed patients [7]. Several cases of acute pulmonary aspergillosis in immunocompetent patients have been reported [8], [9], [10]. The factors that enable A. fumigatus to cause invasive disease are not currently understood [11].…”

Section: Introductionmentioning

confidence: 99%

Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells

et al. 2012

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Inhalation of Aspergillus fumigatus conidia can cause severe aspergillosis in immunosuppressed people. A. fumigatus produces a large number of secondary metabolites, some of which are airborne by conidia and whose toxicity to the respiratory tract has not been investigated. We found that spores of A. fumigatus contain five main compounds, tryptoquivaline F, fumiquinazoline C, questin, monomethylsulochrin and trypacidin. Fractionation of culture extracts using RP-HPLC and LC-MS showed that samples containing questin, monomethylsulochrin and trypacidin were toxic to the human A549 lung cell line. These compounds were purified and their structure verified using NMR in order to compare their toxicity against A549 cells. Trypacidin was the most toxic, decreasing cell viability and triggering cell lysis, both effects occurring at an IC50 close to 7 µM. Trypacidin toxicity was also observed in the same concentration range on human bronchial epithelial cells. In the first hour of exposure, trypacidin initiates the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H2O2). This oxidative stress triggers necrotic cell death in the following 24 h. The apoptosis pathway, moreover, was not involved in the cell death process as trypacidin did not induce apoptotic bodies or a decrease in mitochondrial membrane potential. This is the first time that the toxicity of trypacidin to lung cells has been reported.

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Gardening can seriously damage your health

Cited by 25 publications

References 5 publications

Occurrence of Aspergillus spp. and Aflatoxin B₁ in Malaysian Foods Used for Human Consumption

Occurrence of Aspergillus spp. and Aflatoxin B₁ in Malaysian Foods Used for Human Consumption

Bioaerosol in Composting Facilities: Occupational Health Risk Assessment

Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells

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Gardening can seriously damage your health

Cited by 25 publications

References 5 publications

Occurrence of Aspergillus spp. and Aflatoxin B1 in Malaysian Foods Used for Human Consumption

Occurrence of Aspergillus spp. and Aflatoxin B1 in Malaysian Foods Used for Human Consumption

Bioaerosol in Composting Facilities: Occupational Health Risk Assessment

Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells

Contact Info

Product

Resources

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Occurrence of Aspergillus spp. and Aflatoxin B₁ in Malaysian Foods Used for Human Consumption

Occurrence of Aspergillus spp. and Aflatoxin B₁ in Malaysian Foods Used for Human Consumption