Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk

Liu, Jinfan; Li, Weizhao; Bian, Yangping; Jiang, Xiaoqing; Zhu, Fuyun; Yin, Fei; Li, Yin; Song, Xiaomei; Guo, Hong; Liu, Jianhui

doi:10.1016/j.phymed.2023.154679

Cited by 17 publications

(3 citation statements)

References 31 publications

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“…The liver, an essential organ, is the core site for fatty acid production and lipid circulation. Inflammation of the liver is important in atherosclerosis, and the inflammatory factors of atherosclerosis are partly derived from the liver [40–41] . In this study, pathological alterations in the aortic plaque and livers were identified using H&E staining.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation of the liver is important in atherosclerosis, and the inflammatory factors of atherosclerosis are partly derived from the liver. [40][41] In this study, pathological alterations in the aortic plaque and livers were identified using H&E staining. The aortic plaque area of ApoE À /À mice was reduced with ASBUE intervention, and the pathological conditions of the liver improved to varying degrees.…”

Section: Discussionmentioning

confidence: 99%

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Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Jia

Shi

Zhang

et al. 2023

Chemistry & Biodiversity

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This study investigated the effect of butanol extract of AS (ASBUE) on atherosclerosis in apolipoprotein Edeficient (ApoE À /À ) mice. The mice were administered ASBUE (390 or 130 mg/kg/day) or rosuvastatin (RSV) via oral gavage for eight weeks. In ApoE À /À mice, ASBUE suppressed the abnormal body weight gain and improved serum and liver biochemical indicators. ASBUE remarkably reduced the aortic plaque area, improved liver pathological conditions, and lipid metabolism abnormalities, and altered the intestinal microbiota structure in ApoE À /À mice. In the vascular tissue of ASBUE-treated mice, P-IKKβ, P-NFкB, and P-IкBα levels tended to decrease, while IкB-α increased in high fat-diet-fed atherosclerotic mice. These findings demonstrated the antiatherosclerotic potential of ASBUE, which is mediated by the interaction between the gut microbiota and lipid metabolism and regulated via the Nuclear Factor-kappa B (NF-кB) pathway. This work paves the groundwork for subsequent studies to develop innovative drugs to treat atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Jia

Shi

Zhang

et al. 2023

Chemistry & Biodiversity

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“…Macrophage-hepatocyte crosstalk plays a key role in GDE inhibition of the inflammatory response and enhancement of hepatocyte lipid metabolism, thereby improving NAFLD symptoms. 69 These findings lay the foundation for studying the cellular and molecular mechanisms underlying interspecies communication in the liver via edible plant-derived nanoparticles. Human tonsil-derived MSCs (T-MSCs) are a novel source of MSCs, and a study investigating the effects of T-MSC-derived small EVs (sEVs) on liver fibrosis showed that T-MSC-sEVs inhibited HSCs activation and hindered liver fibrosis.…”

Section: Special Evs In Liver Diseases Therapymentioning

confidence: 95%

Native and engineered extracellular vesicles: novel tools for treating liver disease

Jiang,

Tian,

Wang

et al. 2024

J. Mater. Chem. B

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MicroRNAs Dependent G‐ELNs Based Intervention Improves Glucose and Fatty Acid Metabolism While Protecting Pancreatic β‐Cells in Type 2 Diabetic Mice

Bajaj,

Choudhary,

Singh

et al. 2024

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Metabolic disorders such as Type 2 diabetes mellitus (T2DM) imposes a significant global health burden. Plant‐derived exosome like nanoparticles (P‐ELNs) have emerged as a promising therapeutic alternate for various diseases. Present data demonstrates that treatment with Ginger‐derived exosome like nanoparticles (G‐ELNs) enhance insulin dependent glucose uptake, downregulate gluconeogenesis and oxidative stress in insulin resistant HepG2 cells. Furthermore, oral administration of G‐ELNs in T2DM mice decreases fasting blood glucose levels and improves glucose tolerance as effectively as metformin. These improvements are attributed to the enhanced phosphorylation of Protein kinase B (Akt‐2), the phosphatidylinositol 3‐kinase at serine 474 which consequently leads to increase in hepatic insulin sensitivity, improvement in glucose homeostasis and decrease in ectopic fat deposition. Oral administration of G‐ELNs also exerts protective effect on Streptozotocin (STZ)‐induced pancreatic β‐cells damage, contributing to systemic amelioration of T2DM. Further, as per computational tools, miRNAs present in G‐ELNs modulate the phosphatidylinositol 3‐kinase (PI3K)/Akt‐2 pathway and exhibit strong interactions with various target mRNAs responsible for hepatic gluconeogenesis, ectopic fat deposition and oxidative stress. Furthermore, synthetic mimic of G‐ELNs miRNA effectively downregulates its target mRNA in insulin resistant HepG2 cells. Overall, the results indicate that the miRNAs present in G‐ELNs target hepatic metabolism thus, exerting therapeutic effects in T2DM.

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Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk

Cited by 17 publications

References 31 publications

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet

Native and engineered extracellular vesicles: novel tools for treating liver disease

MicroRNAs Dependent G‐ELNs Based Intervention Improves Glucose and Fatty Acid Metabolism While Protecting Pancreatic β‐Cells in Type 2 Diabetic Mice

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