Garlic extract favorably modifies markers of endothelial function in obese patients –randomized double blind placebo-controlled nutritional intervention

Szulińska, Monika; Kręgielska-Narożna, Matylda; Świątek, Joanna; Styś, Paulina; Kuźnar-Kamińska, Barbara; Jakubowski, Hieronim; Walkowiak, Jarosław; Bogdański, Paweł

doi:10.1016/j.biopha.2018.03.131

Cited by 43 publications

(49 citation statements)

References 52 publications

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“…For example, the antioxidant properties of aged garlic extract (AGE) decrease reactive oxygen species, which are produced through increased metabolism or chronic inflammation, thus preventing the endothelial dysfunction, an early marker of atherosclerosis [ 32 ]. In a randomized double-blind placebo-controlled nutritional intervention, garlic extract (GE) intake at 400 mg/day for three months enhanced antioxidant status, reducing in turn the cardiovascular risk in obese patients through modulating endothelial biomarkers, such as C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL), high-density lipoprotein (HDL) levels, triglycerides (TGs), and plasminogen activator inhibitor-1 (PAI-1) [ 33 ]. Moreover, in diabetic patients after 30 days of supplementation with 3.6 g garlic clove per day, enhanced antioxidant activities, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, significantly increased in circulating human erythrocytes compared with control [ 34 ].…”

Section: Clinical Trials On Garlicmentioning

confidence: 99%

“…On the other hand, AGE at 6 g daily for 12 weeks reduced the levels of lipoprotein B and raised HDL levels, showing cardioprotective effect in patients with mild hypercholesterolemia [ 55 ]. In addition, GE administrated at 400 mg per day for three months modified the markers of endothelial function such as hs-CRP, PAI-1, cholesterol (total, LDL, HDL) and triglycerides as well as suppressed chronic inflammation in obese individuals [ 33 ], probably also modulating by ATP-binding cassette (ABC) A1 or ABCG1 expressions in peripheral blood mononuclear cells (PBMCs) [ 89 ]. Another meta-analysis suggested that garlic has a cardioprotective effect by decreasing serum TC and TG levels in patients with mild hypercholesterolemia [ 90 ].…”

Section: Clinical Trials On Garlicmentioning

confidence: 99%

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Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

et al. 2020

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Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.

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Section: Clinical Trials On Garlicmentioning

confidence: 99%

Section: Clinical Trials On Garlicmentioning

confidence: 99%

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

et al. 2020

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“…Lifestyle change including dietary interventions and physical activity is regarded as an inevitable part of obesity treatment strategies (Swift, Johannsen, Lavie, Earnest, & Church, ). Although reduced dietary energy intake is an important part of weight‐reducing diets, a number of studies have revealed that including functional foods like cinnamon, ginger, pepper, cumin, and garlic (Ebrahimzadeh Attari, Ostadrahimi, Asghari Jafarabadi, Mehralizadeh, & Mahluji, ; Gupta Jain, Puri, Misra, Gulati, & Mani, ; Szulinska et al, ; Zare, Heshmati, Fallahzadeh, & Nadjarzadeh, ; Zheng, Zheng, Feng, Zhang, & Xiao, ) in the diet might improve the weight reduction.…”

Section: Introductionmentioning

confidence: 99%

Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta‐analysis of controlled clinical trials

Yazdanpanah

Azadi-Yazdi

Hooshmandi

et al. 2019

Phytotherapy Research

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Background This systematic review and meta‐analysis aimed to investigate the effect of cinnamon on body weight, body mass index (BMI), waist circumference (WC), waist–hip ratio (WHR), and body fat mass including the maximum number of studies. Methods Medline, ISI Web of Science, Scopus, Google Scholar, and Cochrane library were searched with no limitation from inception up to August 2019 for relevant randomized controlled clinical trials (RCTs). The RCTs' risk of bias was assessed using the Cochrane collaboration's tool. Random‐effects model was used for meta‐analysis. Results Twenty‐one RCTs with 1,480 participants were included. The meta‐analysis showed that cinnamon supplementation significantly reduces BMI [weighted mean difference (WMD) = −0.40 kg/m2, 95% confidence interval (CI): −0.57, −0.22 kg/m2, p < .001, I2 = 78.9%], body weight (WMD = −0.92 kg; 95% CI: −1.51, −0.33 kg; p = .002; I2 = 84.2%), and WHR (WMD = −0.02, 95% CI: −0.038, −0.018; p < 0.001; I2 = 0%). Cinnamon supplementation did not significantly affect the WC (WMD = −1.76 cm, 95% CI: −3.57, −0.045 cm; p = .056; I2 = 90.8%) and body fat mass (WMD = −0.87%, 95% CI: −1.87, 0.025%; p = .057; I2 = 78.6%). Conclusion Cinnamon supplementation significantly reduces body weight, BMI, and WHR. Future high‐quality long‐term RCTs are recommended to confirm these results.

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“…An RCT in patients with CAD showed no statistically significant changes in CRP and IL-6 levels after consumption of aged garlic extract 32. In addition, Szulinska et al reported that taking 400 mg garlic extract daily for 3 months could decrease the level of CRP in obese individuals 13. Van Doorn et al showed that consumption of 2.1 g/day garlic powder for 3 months in overweight and smoking subjects had no marked impact on the CRP level 33.…”

Section: Discussionmentioning

confidence: 99%

Effect of garlic intake on inflammatory mediators: a systematic review and meta-analysis of randomised controlled trials

Koushki

Amiri-Dashatan

Pourfarjam

et al. 2020

Postgraduate Medical Journal

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BackgroundGarlic is a species in the onion genus, Allium. Data have shown that garlic has anti-inflammatory activity; however, the findings are inconclusive and inconsistent. We aimed to evaluate the impact of garlic intake on inflammatory mediators through systematic review and meta-analysis of existing data.MethodsElectronic databases were completely investigated using databases of ISI Web of Science, Medline, Scopus, Cochrane Library and EMBASE until October 2019. A random effects model and the generic reverse variance procedure were used for quantitative data production. Sensitivity analyses and prespecified subgroup were done to evaluate potential heterogeneity. Random effect meta-regression was conducted to investigate the effects of possible confounders on the assessed effect size.ResultsTen trials with one observational study, including 530 participants, met the eligibility criteria. The findings showed reduction in the tumour necrosis factor alpha (TNF-α) (−0.31 pg/mL, 95% CI −1.07 to 0.46) and C reactive protein (CRP) levels (−0.20 mg/L, 95% CI −1.4 to 1.05) following supplementation with garlic, although it had no marked impact on the interleukin 6 (IL-6) level (0.37 pg/mL, 95% CI −0.58 to 1.33). In the subgroup analysis, we found that garlic supplementation significantly decreased TNF-α, highly sensitive CRP and IL-6 levels in subgroups of >8, >6 and ≥4 weeks of intervention duration, respectively, and dose of garlic consumption between 2 and 2.4 g/day.ConclusionThese findings suggested that current evidence may support garlic as an adjunct to pharmacological management of metabolic diseases.PROSPERO registration numberCRD42018108816.

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Garlic extract favorably modifies markers of endothelial function in obese patients –randomized double blind placebo-controlled nutritional intervention

Cited by 43 publications

References 52 publications

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta‐analysis of controlled clinical trials

Effect of garlic intake on inflammatory mediators: a systematic review and meta-analysis of randomised controlled trials

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