Gas chromatographic determination of 4-allyloxy-3-chlorophenylacetic acid (alclofenac) and its metabolites

Metabolites of benzofenac (3-chloro-4- benzyloxyphenylacetic acid) were determined in rat, rabbit, dog, and human urine by GC/MS. Before analysis the urine was extracted and the extracts were treated with diazomethane. Deuterium-labelled benzofenac , 3-chloro-4-[( methylene-2H2]- benzolyoxy ) phenylacetic acid was used for the elucidation of the structures of some main metabolites and the determination of trace metabolites. The structures of the metabolites were determined from spectra obtained by electron impact and chemical ionization.

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Determination of metabolites of 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) by GC/MS method

Koruna

Ryska

Kuchař

et al. 1984

Biol. Mass Spectrom.

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High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

Giachetti¹,

Zanolo²,

Poletti³

et al. 1990

J. High Resol. Chromatogr.

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Evaluation of alclofenac treatment regimes in man

Benedetti

Strolin

Roncucci³

et al. 1973

Eur J Clin Pharmacol

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Gas chromatographic determination of 4-allyloxy-3-chlorophenylacetic acid (alclofenac) and its metabolites

Cited by 10 publications

References 1 publication

Determination of metabolites of 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) by GC/MS method

Determination of metabolites of 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) by GC/MS method

High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

Evaluation of alclofenac treatment regimes in man

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