Gas-chromatographic determination of pyrimethamine in tissue

Abstract

A procedure has been developed for the isolation and gas chromatographic determination of the coccidiostat pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) in tissue.

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

“…The limited data available on the kinetics of these compounds in birds suggest that following oral administration, bioavailability can range from 35–80%, and the drugs are widely distributed throughout the body (Fellig et al. , 1971; Cala et al. , 1972; Queralt & Castells, 1985; Loscher et al.…”

Investigation of antimalarial drug pyrimethamine and its interaction with dsDNA by electrochemical and spectroscopic techniques

“…relatively large sample volume, low sensitivity, lack of or requirement of specic synthetic internal standard, and long or sophisticated extraction/chromatographic procedures. [31][32][33][34][35][36][37][38][39] Experimental Materials PYM supplied from Egyptian Company for Chemicals and Pharmaceuticals was used without further purication. Salmon sperm DNA sodium salt (Sigma, D-1626, USA) containing 41.2% G-C base pairs with a molecular weight of z1.3 Â 106 Da (z2000 base pairs) 40 was used as received.…”

Determination of arprinocid in chicken tissues by gas chromatography-mass spectrometry

“…Many different analytical techniques have been used to determine amines including fluorescence measurement after derivatization (Rinde and Troll, 1976; Sturgeon and Schulman, 1975), liquid chromatography using UV detection (Majors, 1973), and gas chromatography using electron-capture detection (Cala et al, 1972). Recently workers have used gas chromatography (GC) coupled with Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065. mass spectrometry (MS) as the detection system to quantitate low-level drug residues in biological extracts, primarily in plasma and urine (Summons et al, 1974;Narasimhachari et al, 1978;Carrington and Frigerio, 1977).…”