Gas chromatographic method for the quantitative determination of lidocaine and its metabolite monoethylglycinexylidide in plasma

Nation, RL; Triggs, E. J.; Selig, Martin K.

doi:10.1016/s0021-9673(00)83718-8

Cited by 28 publications

(2 citation statements)

References 13 publications

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“…Lignocaine and MEGX were quantitated in the biological samples using a previously reported method (Nation, Triggs & Selig, 1976). Total (Free and conjugated) 4-hydroxyxylidine was estimated in urine by a gas chromatographic procedure (Thomas, Morgan & Vine, 1976) but omitting the ethereal extraction at pH 13.…”

Section: Analytical Measurementsmentioning

confidence: 99%

Lignocaine kinetics in cardiac patients and aged subjects.

Nation¹,

Triggs²,

Selig³

1977

Brit J Clinical Pharma

158

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1 The pharmacokinetics following long term intravenous infusion of lignocaine to cardiac patients have been examined. 2 Plasma levels and half‐lives of lignocaine and monoethylglycinexylidide (MEGX) showed wide inter‐patient variability. 3 Toxicity reactions to therapy were associated with elevated lignocaine and/or MEGX plasma levels. 4 In a separate study the effect of age on the pharmacokinetics of lignocaine was examined using bolus doses (50 mg) of the drug to young and aged subjects. 5 Elderly subjects had significantly longer half‐lives for lignocaine compared to younger individuals although no change in plasma clearance occurred. 6 The drug appeared to distribute differently in the aged as reflected by significantly increased apparent volumes of distribution. 7 The 24 h urinary recovery of the major metabolite (total 4‐hydroxyxylidine) showed a significant reduction in the elderly when compared to the young. 8 The clinical significance of these studies with respect to lignocaine therapy has been discussed.

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Section: Analytical Measurementsmentioning

confidence: 99%

Lignocaine kinetics in cardiac patients and aged subjects.

Nation¹,

Triggs²,

Selig³

1977

Brit J Clinical Pharma

158

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“…Methods 300 and 360 min after commencement of drug administration. Plasma samples were stored at -20°C until assayed by gas liquid chromatography (Nation et al, 1976). The plasma protein binding of lignocaine was measured by equilibrium dialysis, at 37°C using a tracer quantity (1 ug/ml) of ['4C]-lignocaine (New England Nuclear, purity greater than 98%), on the pre-injection sample.…”

Section: Introductionmentioning

confidence: 99%

Lack of effect of ranitidine on the disposition of lignocaine.

Feely¹,

Guy²

1983

Brit J Clinical Pharma

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Cimetidine has been shown to alter the disposition of lignocaine and other drugs that are highly extracted by the liver. In a placebo controlled study ranitidine (150 mg twice daily) did not alter the elimination half-life, systemic clearance or distribution of lignocaine (1 mg/kg) in six healthy subjects. The interaction with cimetidine appears to be unrelated to histamine H2-receptor antagonism.

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Analysis of local anaesthetics

Tucker¹,

Lennard²

1984

Analytical Methods in Human Toxicology

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Gas chromatographic method for the quantitative determination of lidocaine and its metabolite monoethylglycinexylidide in plasma

Cited by 28 publications

References 13 publications

Lignocaine kinetics in cardiac patients and aged subjects.

Lignocaine kinetics in cardiac patients and aged subjects.

Lack of effect of ranitidine on the disposition of lignocaine.

Analysis of local anaesthetics

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