Gas chromatographic sample introduction into the collision cell of a triple quadrupole mass spectrometer for mass-selection of reactant ions for charge exchange and chemical ionization

Hail, Mark E.; Berberich, David W.; Yost, Richard A.

doi:10.1021/ac00192a019

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…However, this severely limits the range of compounds that can be analyzed in a single chromatogram (14). A second approach is to program the flow rate of the carrier gas instead of the temperature (12,(14)(15)(16)(17)(18)(19). Due to the high permeability of open tubular columns, the reequilibration time is relatively short, but the range of boiling…”

mentioning

confidence: 99%

Theoretical and practical aspects of short open tubular columns at subambient pressures in gas chromatography/mass spectrometry

Hail¹,

Yost²

1989

Anal. Chem.

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confidence: 99%

Theoretical and practical aspects of short open tubular columns at subambient pressures in gas chromatography/mass spectrometry

Hail¹,

Yost²

1989

Anal. Chem.

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“…200-ng quantities reported here provide high signalto-noise ratios for those analytes that react. Previous studies of charge-exchange reactions in the collision cell have yielded full-scan detection limits of 100 pg [12].…”

Section: Discussionmentioning

confidence: 99%

“…The reaction of pyridine with various electrophiles was studied in the collision cell of a Finnigan MAT TSQ 70 triple quadrupole mass spectrometer. The concepts, instrumentation, and performance of GC introduction into the second quadrupole (collision cell, Q2) of a tandem mass spectrometer were described previously [12]. Pyridine was introduced continuously into the ion source by a Granville Phillips fine-metering valve, and the analytes were introduced into the collision cell by means of a J&W Scientific 6m DB-5 (0.178 mm i.d., 0.4 IJ.m film thickness) capillary column.…”

Section: Reactions In the Collision Cellmentioning

confidence: 99%

Estimation of mutagenic/carcinogenic potential of environmental contaminants by ion-molecule reactions and tandem mass spectrometry

Freeman

Johnson

Hail

et al. 1990

J. Am. Soc. Mass Spectrom.

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The ability to produce and detect products of model DNA/carcinogen ion-molecule reactions is demonstrated in the ion source and the collision cell of a triple quadrupole tandem mass spectrometer. Reaction between adenine and benzoyl chloride in the ion source is shown to produce the DNA adduct benzoyl adenine. The daughter ion mass spectrum of the reaction product is compared to that of the synthesized standard. Mass chromatograms of the reaction between mass-selected pyridine ions and various analytes eluting from a GC column into the collision cell are demonstrated and illustrate the ability to detect only the GC eluates that react with pyridine. This technique could provide a rapid and sensitive method for screening complex environmental samples for carcinogens, as well as for estimating the relative mutagenic/carcinogenic potential of environmental contaminants.

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“…Hail et a1. 22 have interfaced a gas chromatograph to the collision cell of a triple quadrupole instrument and have shown that the aromatic components of a test mixture can be selectively ionized as they elute from the gas chromatograph by using charge exchange from mass-selected [c6H6] + * (benzene) ions. S~h r O d e r~~ also has demonstrated the ionization of toluene in a quadrupole cell by charge exchange with mass-selected Ar+' ions.…”

Section: Introductionmentioning

confidence: 99%

Reactive collisions in quadrupole cells. Part I. Reaction of [CH₃NH₂]⁺˙ with the isomeric butenes and pentenes

Usypchuk

Harrison

Wang

1992

Org. Mass Spectrom.

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The reactions of mass-selected [CH3NH21+' ions with the isomeric butenes and pentenes were studied at low collision energies in the radiofrequency-only quadruple collision cell of a hybrid B Q Q tandem mass spectrometer. Characteristic iminium ions arising by addition of the methylamine to the oiefin followed by fragmentation are observed for but-l-eae, pent-l-ene and Imethylbut-l-ene. However, for but-sene, pent-2-ene, 2-methylpropene, 2-methylbut-l-ene and %methylbut-2-ene, the major reaction channel of [ CH,NH2 I +' is charge exchange to form the olefinic molecular ion. The isomeric olefins are characterized, to a considerable extent, by the characteristic ion-molecule reactions that these molecular ions undergo with the neutral olefin.

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Gas chromatographic sample introduction into the collision cell of a triple quadrupole mass spectrometer for mass-selection of reactant ions for charge exchange and chemical ionization

Cited by 11 publications

References 21 publications

Theoretical and practical aspects of short open tubular columns at subambient pressures in gas chromatography/mass spectrometry

Theoretical and practical aspects of short open tubular columns at subambient pressures in gas chromatography/mass spectrometry

Estimation of mutagenic/carcinogenic potential of environmental contaminants by ion-molecule reactions and tandem mass spectrometry

Reactive collisions in quadrupole cells. Part I. Reaction of [CH₃NH₂]⁺˙ with the isomeric butenes and pentenes

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Gas chromatographic sample introduction into the collision cell of a triple quadrupole mass spectrometer for mass-selection of reactant ions for charge exchange and chemical ionization

Cited by 11 publications

References 21 publications

Theoretical and practical aspects of short open tubular columns at subambient pressures in gas chromatography/mass spectrometry

Theoretical and practical aspects of short open tubular columns at subambient pressures in gas chromatography/mass spectrometry

Estimation of mutagenic/carcinogenic potential of environmental contaminants by ion-molecule reactions and tandem mass spectrometry

Reactive collisions in quadrupole cells. Part I. Reaction of [CH3NH2]+˙ with the isomeric butenes and pentenes

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Reactive collisions in quadrupole cells. Part I. Reaction of [CH₃NH₂]⁺˙ with the isomeric butenes and pentenes