Gas Chromatography in Screening of Chemicals Related to the Chemical Weapons Convention

Kostiainen, Olli

doi:10.1002/0470012285.ch10

Cited by 5 publications

(1 citation statement)

References 82 publications

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“…Analysis proceeds following thermal desorption of the trap, but when used in this way, the long sample probe inlet of this instrument (1 m) is kept at a relatively cool 40 °C for power management. This limits trace-level detection to semivolatile compounds with retention indices less than about 1300, although several CWA compounds and their degradation compounds are semivolatile, with retention indices of greater than ∼1250. ,, Thus, a capabilities gap exists for direct air sampling and integrated analysis for these less volatile analytes with the widely used Hapsite system.…”

Section: Resultsmentioning

confidence: 99%

Application of a High Surface Area Solid-Phase Microextraction Air Sampling Device: Collection and Analysis of Chemical Warfare Agent Surrogate and Degradation Compounds

et al. 2013

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This work examines a recently improved, dynamic air sampling technique, high surface area solid-phase microextraction (HSA-SPME), developed for time-critical, high-volume sampling and analysis scenarios. The previously reported HSA-SPME sampling device, which provides 10-fold greater surface area compared to commercially available SPME fibers, allowed for an increased analyte uptake per unit time relative to exhaustive sampling through a standard sorbent tube. This sampling device has been improved with the addition of a type-K thermocouple and a custom heater control circuit for direct heating, providing precise (relative standard deviation ∼1%) temperature control of the desorption process for trapped analytes. Power requirements for the HSA-SPME desorption process were 30-fold lower than those for conventional sorbent-bed-based desorption devices, an important quality for a device that could be used for field analysis. Comparisons of the HSA-SPME device when using fixed sampling times for the chemical warfare agent (CWA) surrogate compound, diisopropyl methylphosphonate (DIMP), demonstrated that the HSA-SPME device yielded a greater chromatographic response (up to 50%) relative to a sorbent-bed method. Another HSA-SPME air sampling approach, in which two devices are joined in tandem, was also evaluated for very rapid, low-level, and representative analysis when using discrete sampling times for the compounds of interest. The results indicated that subparts per billion by volume concentration levels of DIMP were detectable with short sampling times (∼15 s). Finally, the tandem HSA-SPME device was employed for the headspace sampling of a CWA degradation compound, 2-(diisopropylaminoethyl) ethyl sulfide, present on cloth material, which demonstrated the capability to detect trace amounts of a CWA degradation product that is estimated to be less volatile than sarin. The rapid and highly sensitive detection features of this device may be beneficial in decision making for law enforcement, military, and civilian emergency organizations and responders, providing critical information in a contaminated environment scenario when time is of the essence.

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Section: Resultsmentioning

confidence: 99%

Application of a High Surface Area Solid-Phase Microextraction Air Sampling Device: Collection and Analysis of Chemical Warfare Agent Surrogate and Degradation Compounds

et al. 2013

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Gas chromatography/mass spectrometric analysis of methyl esters of N,N‐dialkylaminoethane‐2‐sulfonic acids for verification of the Chemical Weapons Convention

Pardasani¹,

Gupta²,

Palit³

et al. 2005

Rapid Comm Mass Spectrometry

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This paper describes the synthesis and gas chromatography/electron ionization mass spectrometric (GC/EI-MS) analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids (DAESAs). These sulfonic acids are important environmental signatures of nerve agent VX and its toxic analogues, hence GC/EI-MS analysis of their methyl esters is of paramount importance for verification of the Chemical Weapons Convention. DAESAs were prepared by condensation of 2-bromoethane sulfonic acid with dialkylamines, and by condensation of dialkylaminoethyl chloride with sodium bisulfite. GC/EI-MS analysis of methyl esters of DAESAs yielded mass spectra; based on these spectra, generalized fragmentation routes are proposed that rationalize most of the characteristic ions.

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Gas chromatography/mass spectrometric analysis of N,N‐dialkylaminoethyl‐2‐chlorides and trimethylsilyl derivatives of N,N‐dialkylaminoethan‐2‐ols for verification of the Chemical Weapons Convention

Gupta

Pardasani

Kanaujia

et al. 2006

Rapid Comm Mass Spectrometry

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Gas chromatography/electron ionization mass spectrometry (GC/EI-MS) of N,N-dialkylaminoethyl-2-chlorides (DAAECls) and trimethylsilyl (TMS) derivatives of N,N-dialkylaminoethan-2-ols (DAAEAs) has been carried out. GC/EI-MS data of these compounds are of importance for verification of the Chemical Weapons Convention (CWC). Based on these EI mass spectra, generalized fragmentation routes are proposed that rationalize most of the characteristic ions.

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Gas Chromatography in Screening of Chemicals Related to the Chemical Weapons Convention

Cited by 5 publications

References 82 publications

Application of a High Surface Area Solid-Phase Microextraction Air Sampling Device: Collection and Analysis of Chemical Warfare Agent Surrogate and Degradation Compounds

Application of a High Surface Area Solid-Phase Microextraction Air Sampling Device: Collection and Analysis of Chemical Warfare Agent Surrogate and Degradation Compounds

Gas chromatography/mass spectrometric analysis of methyl esters of N,N‐dialkylaminoethane‐2‐sulfonic acids for verification of the Chemical Weapons Convention

Gas chromatography/mass spectrometric analysis of N,N‐dialkylaminoethyl‐2‐chlorides and trimethylsilyl derivatives of N,N‐dialkylaminoethan‐2‐ols for verification of the Chemical Weapons Convention

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