Gas chromatography with mass spectrometry for the quantification of ethylene glycol ethers in different household cleaning products

Abstract

A rapid and simple procedure is reported for the determination of six ethylene glycol ethers in cleaning products and detergents using gas chromatography with mass spectrometry. The analytes were extracted from 2.0 g samples in acetonitrile (3 mL) and the extract was submitted to a clean-up step by QuEChERS method, using a mixture containing 0.3 g magnesium sulfate, 0.15 g primary/secondary amine, and 0.05 g C18 . The clean acetonitrile extract (1 μL) was injected into the chromatographic system. No matrix effect was observed, so the quantification of the samples was carried out against external standards. Detection limits were in the range 3.0-27 ng/g for the six ethylene glycol ethers. The recoveries obtained, using the optimized procedure, were in the 89.4-118% range, with relative standard deviations lower than 14%. Twenty-three different household cleaning products, including glass cleaner, degreaser, floor, softeners, and clothes and dishwashing detergents, were analyzed. Large interindividual variations were observed between samples and compounds.

Surface Tension and Density of Ethylene Glycol Monobutyl Ether–Water Mixtures from 277.15 to 308.15 K

“…The alcohol from which it is synthesized ( n -butanol) is partially soluble in water at room conditions, with an upper critical solubility temperature ( T = 403.1 K and a molar fraction of 0.1070). , The addition of an ethylene oxide (EO) molecule, as part of the hydrophilic region, dramatically changes its physical properties to a completely miscible solvent in water at room temperature and the phase diagram changes to a closed two-phase loop with an upper and lower critical solubility temperature (around 402.86 and 322.12 K for the upper and lower critical solution temperature, respectively). − EO provides an important surface activity, making EGBE one of the smallest surfactants. EGBE application scope covers several uses: as a component in fracturing and drilling fluids for the petroleum industry, , as an additive in ink, lacquers, varnishes, and enamels in the painting industry, , and as a cosurfactant in cleaning products, − among others. To predict its performance in such applications, it is important to know its physical properties, especially the surface tension behavior in aqueous systems.…”

Simultaneous determination of glycol ethers and their acetates in cosmetics by gas chromatography with mass spectrometry

“…Until now, most of the reported methods for the determination of glycol ethers and their acetates were mainly based on GC , GC–MS , and HPLC–MS/MS . The analyzed samples in these studies were focused on environmental samples, leather products, foods, toys, textiles, and decorating and refurbishing materials.…”

Determination of sulfonate ester genotoxic impurities in imatinib mesylate by gas chromatography with mass spectrometry

“…However, the method presents an LOQ of about 5 g/g and an LOD of about 1 g/g, which are high levels for detecting genotoxins in pharmaceuticals and unsuitable for use. In recent years, the use of MS for the quantitative analysis of trace-level impurities has increased [11,12]. Lee et al [13] reported a GC-MS method, wherein mesylate esters are derivatized with aqueous sodium thiocyanate.…”