Gas chromatography with parallel hard and soft ionization mass spectrometry

Hejazi, Leila; Guilhaus, Michael; Hibbert, David Brynn; Ebrahimi, Diako

doi:10.1002/rcm.7091

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…The authors were able to use soft ionisation MS to achieve good compound class separation on the basis of their parent masses. Hejazi et al 130 developed a method that utilises GC with parallel EI and FI-MS that consists of two mass spectrometers connected to a single GC. The dual source instrument generates equivalent chromatograms aligned in time, allowing accurate assignment of fragment ions (from EI) to the corresponding molecular ions (from FI).…”

Section: Recent Advances In Application Of Gc × Gc Analysismentioning

confidence: 99%

Recent advances in the application of 2-dimensional gas chromatography with soft and hard ionisation time-of-flight mass spectrometry in environmental analysis

Alam

Harrison

2016

Chem. Sci.

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Section: Recent Advances In Application Of Gc × Gc Analysismentioning

confidence: 99%

Recent advances in the application of 2-dimensional gas chromatography with soft and hard ionisation time-of-flight mass spectrometry in environmental analysis

Alam

Harrison

2016

Chem. Sci.

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“…Studying the mass spectra of small organic biomolecules, ions with higher masses, DMT-dinucleotide, small poly-aromatic hydrocarbons, medicinal agents, and other biopolymers [19,20]…”

Section: Nano Electrospray Ionizationmentioning

confidence: 99%

Mass Spectrometry for Comprehensive Analysis of Metabolites

Farid¹,

Bashir²,

Ali³

2022

PJMHS

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Mass spectrometry is a highly sensitive high output instrumental analytical technique. It is used to determine the molecular mass but also gives the information on molecular structure and is used for quantification as well. It involves the measurement of mass to charge ratios of ions. It has become an essential tool in biological research and can be used to characterize a wide variety of biomolecules such as sugars, proteins, and oligonucleotides. Although it was developed 100 years ago, it continues to evolve both with respect to merit and applications in various fields of science and technology. Mass spectrometry is a field of studying macromolecules like proteins and complexes and has very high sensitivity also now compounds at the atom level can also be studied. In this present review, a brief history of mass spectrometry is discussed, and the basic principles of the technology are introduced. A summary of some current applications of mass spectrometry, current methods used to identify, quantify, and characterize proteins and peptides are then reviewed. The range of applications of mass spectrometry is considerable and only promises to grow as the technology continues to improve. Keywords: Mass spectrometry, Biomolecules, Structure Elucidation, Molecular mass, Natural, Medicines drugs

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“…For the identification of nonpolar or derivatized volatile thermostable metabolites, GC-MS systems with hard ionization methods, such as electron impact or chemical ionization, are preferred. To increase the ionization of diverse metabolites and to enhance the metabolite coverage, dual-source MS instruments, combining atmospheric pressure chemical ionization and ESI for LC systems (47) and soft and hard ionization for GC systems (48), can be used.…”

Section: Metabolite Identification and Databasesmentioning

confidence: 99%

Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products

Simmler

Kulakowski

Lankin

et al. 2016

Advances in Nutrition

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In the field of food and nutrition, complex natural products (NPs) are typically obtained from cells/tissues of diverse organisms such as plants, mushrooms, and animals. Among them, edible fruits, grains, and vegetables represent most of the human diet. Because of an important dietary dependence, the comprehensive metabolomic analysis of dietary NPs, performed holistically via the assessment of as many metabolites as possible, constitutes a fundamental building block for understanding the human diet. Both mass spectrometry (MS) and nuclear magnetic resonance (NMR) are important complementary analytic techniques, covering a wide range of metabolites at different concentrations. Particularly, 1-dimensional 1H-NMR offers an unbiased overview of all metabolites present in a sample without prior knowledge of its composition, thereby leading to an untargeted analysis. In the past decade, NMR-based metabolomics in plant and food analyses has evolved considerably. The scope of the present review, covering literature of the past 5 y, is to address the relevance of 1H-NMR–based metabolomics in food plant studies, including a comparison with MS-based techniques. Major applications of NMR-based metabolomics for the quality control of dietary NPs and assessment of their nutritional values are presented.

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Gas chromatography with parallel hard and soft ionization mass spectrometry

Cited by 12 publications

References 16 publications

Recent advances in the application of 2-dimensional gas chromatography with soft and hard ionisation time-of-flight mass spectrometry in environmental analysis

Recent advances in the application of 2-dimensional gas chromatography with soft and hard ionisation time-of-flight mass spectrometry in environmental analysis

Mass Spectrometry for Comprehensive Analysis of Metabolites

Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products

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