Gas–liquid selective oxidations with oxygen under explosive conditions in a micro-structured reactor

Leclerc, Arnaud; Alame, M.; Schweich, D.; Pouteau, Patrick; Delattre, Cyril; Bellefon, Claude de

doi:10.1039/b717985e

Cited by 74 publications

(63 citation statements)

References 19 publications

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“…De Bellefon et al [15] have investigated the industrially important gas-liquid selective oxidation of cyclohexane with oxygen to give cyclohexanone, cyclohexanol, and cyclohexylhydroperoxide under explosive conditions in silicon-made microreactors (for the setup see Fig. 5).…”

Section: Microreactorsmentioning

confidence: 99%

Selected Examples of High‐Pressure Reactions in Glass Microreactors

Verboom

2009

Chem Eng & Technol

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Recent examples of high-pressure organic reactions in (flow) glass microreactors of micrometer dimensions are described. Different types of reactions such as Diels-Alder and nucleophilic aromatic substitution reactions performed in a capillary microreactor gave rate enhancements of 1.5-2.7 at 600 bar. Specifically designed flow glass microreactors, that withstand pressures of 140-690 bar, were used to study Diels-Alder and oxidation reactions. The use of supercritical fluids gives rise to considerable rate enhancements, while the use of a transparent microreactor allows to visualize phase transitions.

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Section: Microreactorsmentioning

confidence: 99%

Selected Examples of High‐Pressure Reactions in Glass Microreactors

Verboom

2009

Chem Eng & Technol

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“…This internal circulation results in homogeneous mixing and facilitates a fast mass transfer between the two phases. [79][80][81][82] Interestingly, a microreactor operating in the Taylor flow regime shows minimal axial dispersion and provides an excellent residence time distribution, making it behave as an ideal plug flow reactor. [82][83][84][85][86][87] mass transfer organic molecules A(g) A(l) products oxidation…”

Section: Mass Transfer Limitations In Liquid Phase Oxidationsmentioning

confidence: 99%

“…Bellefon et al developed a chip microreactor setup to selectively oxidize cyclohexane under explosive conditions. 82 Jevtic 134 and Fischer 99 both utilized capillary microreactors. Fraulin used microreactors and studied the progress of the reaction by in situ Raman spectroscopy studies.…”

Section: Uncatalyzed Aerobic Oxidation Processes In Continuous Flowmentioning

confidence: 99%

Liquid phase oxidation chemistry in continuous-flow microreactors

et al. 2016

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Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention as the reactor provides enhanced heat and mass transfer characteristics, safe use of hazardous oxidants, high interfacial areas, and scale-up potential. In this review, an up-to-date overview of both technological and chemical aspects of liquid phase oxidation chemistry in continuous-flow microreactors is given. A description of mass and heat transfer phenomena is provided and fundamental principles are deduced which can be used to make a judicious choice for a suitable reactor. In addition, the safety aspects of continuous-flow technology are discussed. Next, oxidation chemistry in flow is discussed, including the use of oxygen, hydrogen peroxide, ozone and other oxidants in flow. Finally, the scale-up potential for continuous-flow reactors is described.

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“…[25] Using microreactor technology, we have recently shown that aldehydes could be safely and efficiently oxidized into the corresponding carboxylic acid using 5 bar of O 2 at room temperature. [26] This prompted us to re-investigate the continuous-flow aerobic oxidation of primary alcohols with pure O 2 using the Cu/TEMPO catalytic system.…”

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confidence: 99%

Gas–Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO‐Catalyzed Aerobic Oxidation of Primary Alcohols

et al. 2015

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Aerobic oxidation using a combination of copper salts and 2,2,6,6-tetramethylpiperidine Noxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gasliquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover-limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol.

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Gas–liquid selective oxidations with oxygen under explosive conditions in a micro-structured reactor

Abstract: The gas-liquid oxidation of cyclohexane is performed at high temperature (>200 degrees C) and pressure (up to 25 bar) using pure oxygen in a Pyrex capped silicon etched microreactor which allows convenient screen reaction conditions well above the flammability limit.

Cited by 74 publications

References 19 publications

Selected Examples of High‐Pressure Reactions in Glass Microreactors

Selected Examples of High‐Pressure Reactions in Glass Microreactors

Liquid phase oxidation chemistry in continuous-flow microreactors

Gas–Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO‐Catalyzed Aerobic Oxidation of Primary Alcohols

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