Gastrectomy impact on the gut microbiome in patients with gastric cancer: A comprehensive review

Maksimaityte, Vaidota; Baušys, Augustinas; Kryžauskas, Marius; Lukšta, Martynas; Stundiene, Ieva; Bickaite, Klaudija; Bausys, Bernardas; Poškus, Tomas; Baušys, Rimantas; Strupas, Kęstutis

doi:10.4240/wjgs.v13.i7.678

Cited by 17 publications

(13 citation statements)

References 65 publications

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“…Elaine et al showed that the metabolism and microbial composition of gastric cancer patients were significantly altered after Roux-en-Y gastric bypass (RYGB) surgery [ 45 ]. Consistently, Vaidota et al showed that gastric cancer surgery could affect the composition of gastric microbiota [ 46 ]. Liu et al found that the gastric microenvironment determined the composition and diversity of gastric microbiota rather than the stage or type of GC.…”

Section: Microbiota and Gastric Cancermentioning

confidence: 85%

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Host miRNAs-microbiota interactions in gastric cancer

et al. 2022

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It is widely acknowledged that gastric cancer seriously affects the quality of life and survival of patients. The correlation between the microbiota and gastric cancer has attracted extensive attention in recent years, nonetheless the specific mechanism of its impact on gastric cancer remain largely unclear. Recent studies have shown that in addition to its role in the host’s inflammatory and immune response, the microbiota can also affect the occurrence and development of gastric cancer by affecting the expression of miRNAs. This paper brings together all currently available data on miRNAs, microbiota and gastric cancer, and preliminarily describes the relationship among them.

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Section: Microbiota and Gastric Cancermentioning

confidence: 85%

“…Microbial imbalance is also an important factor responsible for cancer, described in detail in the previous paragraph. Importantly, microbial colonization of gastric cancer can be affected by the microenvironment (microbial interaction, surgical operation, stage or type of GC and so on) [ 42 – 46 ].…”

Section: Microbiota and Gastric Cancermentioning

confidence: 99%

Host miRNAs-microbiota interactions in gastric cancer

et al. 2022

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“…The protection of intestinal function plays a very important role in radical gastrointestinal tumor resection. The impairment of the intestinal barrier function can increase the risk of postoperative infectious complications, multiple organ failure, and mortality, and exacerbate local and systemic inflammatory stress responses in the intestine, influence the composition of the gut microbiome (24), leading to prolonged postoperative recovery (25). In this…”

Section: Discussionmentioning

confidence: 99%

Association between preoperative nutritional status, inflammation, and intestinal permeability in elderly patients undergoing gastrectomy: a prospective cohort study

Zhao

Wang

Yang

et al. 2022

J Gastrointest Oncol

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Background: Malnutrition is relatively common among elderly patients with gastric cancer. This study sought to analyze whether preoperative nutritional status, inflammatory cytokines, and intestinal permeability were correlated in elderly gastric cancer patients undergoing surgery, and their effects on postoperative recovery. Methods: This study was a single-center prospective cohort study. Patients aged 65-90 years who underwent gastrectomy were included. Preoperative nutritional status was assessed by the Mini Nutritional Score (MNA), Nutritional Risk Screening-2002 (NRS2002), body mass index (BMI), free fatty acids (FFAs), albumin, and prealbumin concentrations. Intestinal permeability was assessed by D-lactate and intestinal fatty acid-binding protein (i-FABP). The inflammatory factors included interleukin (IL)-6, IL-10, neutrophil, and lymphocyte counts. The time to first defecation, time to first liquid diet, length of hospital stay (LOS), and postoperative complications were recorded.Results: A total of 134 patients were included. According to the MNA, 50.7% and 32.1% of the cohort had mild to moderate malnutrition, and severe malnutrition, respectively. According to the NRS2002, 38.8% of the patients scored >4 points. I-FABP was significantly negatively correlated with albumin (r=-0.409, P<0.001) and prealbumin (r=-0.397, P<0.001), and significantly positively correlated with MNA (r=0.291, P=0.001), the NRS2002 (r=0.284, P=0.001), and LOS (r=0.245, P=0.004). D-lactate was significantly negatively correlated with BMI (r=-0.229, P=0.008), albumin (r=-0.426, P<0.001), and prealbumin (r=-0.358, P<0.001), and significantly positively correlated with the NRS2002 (r=0.187, P=0.030), time to first defecation (r=0.264, P=0.002), and LOS (r=0.409, P<0.001). There were significant differences in BMI, prealbumin, FFAs, i-FABP, time to first defecation, and time to first fluid diet (P<0.05) among groups based on MNA score. The multivariate logistic analysis showed that D-lactate was an independent risk factor of postoperative complications [odds ratio (OR) =1.354, 95% confidence interval (CI): 1.099-1.669, P=0.004]. Conclusions:The preoperative intestinal permeability indicators (i.e., D-lactate and i-FABP) are significantly correlated with some nutritional indicators and postoperative recovery indicators. The preoperative D-lactate level is an independent risk factor of postoperative complications, suggesting that altered gut barrier function before surgery could to some extent influence postoperative recovery in the elderly.

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“…Gastric cancer is the most common malignancies in the world. Gastrectomy is still the only potentially curative treatment for this disease [29]. Gastric cancer is as well as esophageal cancer is one of the two major causes of cancer-related deaths in the world [30].…”

Section: Gut Microbiome Dysbiosis In Various Malignanciesmentioning

confidence: 99%

“…Bacterial dysbiosis in the stomach can strengthen gastric neoplasia development via generating tumor-promoting metabolites, DNA damage, suppressing antitumor immunity, and activating oncogenic signaling pathways [35]. Dysbiosis after gastrectomy is characterized by increased microbiome consisting of typical oral cavity bacteria, characterized by increased aero-tolerant bacteria (aerobes/facultative anaerobes), and increased genera of bile acid-transforming bacteria [29]. Lower abundance of Bifidobacteriaceae was seen only in diffuse adenocarcinoma and of Oscillibacter in intestinal adenocarcinoma [36].…”

Section: Gut Microbiome Dysbiosis In Various Malignanciesmentioning

confidence: 99%

New Horizon on Gut Microbiome and Cancers: Recent Information on Pathogenesis and Treatment

Fukui¹

2022

AJIM

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An increasing number of studies have suggested that gut microbiota is closely related to tumor pathogenesis and their treatments. Among cancers, there have been many reports concerning gut microbiome and colon cancer (CRC), where microbial dysbiosis with depressing the population of "benign microbes" and increasing "harmful microbes" can lead to chronic enterocolitis and cancer development with progression. In addition, gut dysbiosis may change the metabolism of bile acids promoting CRC, which would offer a potential preventive therapeutic change in CRC by regulating gut microbiome and bile acid metabolism. Recently, SARS-CoV-2 impacts the gut microbiota, and the effects will have on CRC carcinogenesis. Obesity is estimated as an important factor that increases the risk of CRC. There has been accumulating evidence that the modulation of the gut microbiota composition by probiotics, prebiotics, and diets protects patients with CRC. Hepatocellular carcinoma (HCC) as the third leading cause of worldwide cancer mortality. Development of HCC in cirrhotic patients is related to changes in intestinal microbiome, including an escalation of dysbiosis and reduced bacterial richness. The species richness of fecal microbiota of hepatitis B-HCC patients was much high. The alterations of fecal microbiome may affect the process of Helicobacter pylori (H. pylori)-related progression of gastric lesion. Patients with gastric cancer have distinct microbiome in the stomach with lower biodiversity. Some bacteria from gastric microbiome are potentially carcinogenic as they are changed in gastric cancer. Patients with pancreas cancer and cholangiocarcinoma have also been related to gut dysbiosis. Other malignancies outside the gut like breast cancer (BC) might be related to gut microbiome as they might affect through metabolic, neural, and endocrine signal and immune function in the occurrence and progression of BC. Finally, cancer cachexia might be also associated with gut dysbiosis as it is closely related to bile acids (BA) metabolism regulation. The effects and side effects by variable cancer therapies such as chemotherapy, radiotherapy and also immunotherapy may be reconsidered from gut microbiome.

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Gastrectomy impact on the gut microbiome in patients with gastric cancer: A comprehensive review

Cited by 17 publications

References 65 publications

Host miRNAs-microbiota interactions in gastric cancer

Host miRNAs-microbiota interactions in gastric cancer

Association between preoperative nutritional status, inflammation, and intestinal permeability in elderly patients undergoing gastrectomy: a prospective cohort study

New Horizon on Gut Microbiome and Cancers: Recent Information on Pathogenesis and Treatment

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