Abstract:The mammalian counterpart to bombesin, gastrin-releasing peptide (GRP), is considered to stimulate gastric acid secretion by release of endogenous gastrin. The present study was carried out to examine if GRP has a stimulatory action on acid secretion in addition to that produced by released gastrin. In 4 gastric fistula (GF) and Heidenhain pouch (HP) cats, 160 pmol·kg-1·h-1 i.v. GRP produced a GF and HP acid response that amounted to 22 and 13%, respectively, of the maximal acid response … Show more
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