Gastric Acidity in Normal Individuals

Jacob, Louis; Pierce, F.; Brogan, A. J.

doi:10.1172/jci100398

Cited by 20 publications

(8 citation statements)

References 7 publications

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“…The higher incidence of hyperchlorhydria, however, appears to be paradoxical. Achlorhydria As indicated previously, of the 50 patients with exophthalmic goitre studied, 19 or 38 per cent showed achlorhydria after stimulation with histamine. This percentage becomes all the more significant when compared with the expected result based on normals.…”

Section: Mate'rialsupporting

confidence: 68%

“…The incidence of anacidity in 200 normal patients (19) examined the same way was found to be 13 per cent. The result becomes all the more significant if the comparison is made with those patients falling into the same age groups as our exophthalmic goitre patients, and a correction applied for the difference in age distribution.…”

Section: Mate'rialmentioning

confidence: 74%

“…The technique of obtaining the gastric contents is described in another paper dealing with the gastric analysis in normal people (19). Briefly, it consists in the analysis of three samples of gastric contents, i.e., the fasting contents, and the samples obtained one-half hour and one hour after the subcutaneous injection of 0.5 mgm.…”

Section: Methodsmentioning

confidence: 99%

“…Lockwood (2) studied the gastric contents of 24 patients with hyperthyroidism who had digestive complaints and found 10 or 41.6 per cent showed no free hydrochloric acid, 3 low acid and 11 normal acid. Similarly Moll and Scott (3), in a series of 34 patients with definite exophthalmic goitre, found 19 (56 per cent) with achlorhydria, 10 with hypochlorhydria, 4 with normal acid and 1 with high acid. Herzfeld (4) obtained the following results in 22 cases: achlorhydria and hypoacidity 15, normal acidity 4, and increased acidity 3.…”

mentioning

confidence: 86%

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The Gastric Secretion in Exophthalmic Goitre and Myxoedema

Jacob

Means²

1932

J. Clin. Invest.

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Section: Mate'rialsupporting

confidence: 68%

Section: Mate'rialmentioning

confidence: 74%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 86%

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The Gastric Secretion in Exophthalmic Goitre and Myxoedema

Jacob

Means²

1932

J. Clin. Invest.

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“…) On the basis of these four factors there is no significant difference between those patients in whom gastric acidity returned to normal and those with a persisting achlorhydria. Excluding the eight patients not followed and the two in whom the persisting anacidity may still be associated with a continuation of thyroid disease, there is an incidence of achlorhydria for the group of ten per cent which is not higher than the incidence for normal individuals in this age group (17,18). 49 The results of this study clearly indicate that the gastric acidity in hyperthyroidism is markedly diminished.…”

Section: Methodsmentioning

confidence: 61%

A Study of the Gastric Secretion in Hyperthyroidism Before and After Operation

Berryhill¹,

Williams²

1932

J. Clin. Invest.

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Gastric symptoms have long been associated with hyperthyroidism. The reports of studies attempting to correlate these symptoms with disturbances in gastric secretions are not uniform. Several investigators (I, 2) report an increase in the hydrochloric acid and total volume of secretion. One (3) contends there is no characteristic secretion in exophthalmic goiter. A greater number (4-16) report a diminution or absence of hydrochloric acid in hyperthyroidism and in the feeding of thyroid extracts to animals. Excellent reviews of the subject have appeared in recent papers by Moll and Flint (9), Brown (10), and Lerman and Means (13). With the development of a more accurate method for determining the degree of gastric acidity by histamine stimulation it seemed desirable to restudy the problem. Accordingly, a survey was begun eighteen months ago to determine the behavior of gastric secretion in hyperthyroidism before and after operation. Since the beginning of this work, Lerman and Means (13) have reported a study of gastric secretion in exophthalmic goiter before treatment using a similar method. METHODThe present generally accepted technique of gastric analysis was employed in this study. A fasting specimen was withdrawn, followed by the ingestion of 50 cc. of 7 per cent alcohol. Specimens were removed at twenty and forty minute intervals. If the last specimen contained no hydrochloric acid, histamine (ergotamine acid phosphate) 0.1 mgm. per ten kilograms was given subcutaneously and specimens were withdrawn at twenty and forty minute intervals. The volume, free hydrochloric acid and total acidity of each specimen were determined. T6pfer's reagent and phenolphthalein respectively were used as indicators and the results expressed as the number of cc. of N/1O NaOH necessary to neutralize 100 cc. of gastric juice.Two analyses were done on each patient before preoperative iodine therapy was begun, a third the day before operation, and a fourth the day of discharge. The patients were followed by subsequent analyses at intervals of one to two months. We have arbitrarily classified the results upon the basis of the highest acid content obtained after the stimulation by alcohol and histamine: (1) Normals, those patients in whom repeated analyses showed free hydrochloric 753

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Mechanism of Pain in Gastric and Duodenal Ulcers

Palmer¹

1934

Arch Intern Med (Chic)

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Gastric Acidity in Normal Individuals

Cited by 20 publications

References 7 publications

The Gastric Secretion in Exophthalmic Goitre and Myxoedema

The Gastric Secretion in Exophthalmic Goitre and Myxoedema

A Study of the Gastric Secretion in Hyperthyroidism Before and After Operation

Mechanism of Pain in Gastric and Duodenal Ulcers

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