Gastric adenocarcinoma trends in the central region of Rio Grande do Sul (Southern Brazil): what has changed in 25 years?

Abstract

Over this 25-year period, there were no significant trends in age, gender distribution, or the proportions of cardia and non-cardia gastric adenocarcinomas in this series of patients from Southern Brazil. There was a significant decrease in the intestinal subtype and a steady increase in the diffuse subtype of this malignancy. In patients under 45 years old, gastric cancer was more frequent in women, and the diffuse subtype predominated.

Patho-epidemiological Features of Esophageal and Gastric Cancers in an Endemic Region: a 20-year Retrospective Study

“…Our study was similar to the other studies, (Zhou et al, 2008;Mousavi and Somi, 2009;Babaei et al, 2010;Rampazzo et al, 2012;Rodríguez-Vargas, 2013).…”

“…In addition, our results suggested that sex ratio was 1.53 which is more than study performed in Tabriz province (Bafandeh et al, 2006). Stomach, in the present study, the mean age of patients was about 65 years old which was less than Chinese study (Zhou et al, 2008) and another report from Iran (Aghaei et al, 2013) but similar to some other studies and references (Kumar, 2007;Lauwers, 2009;Babaei et al, 2010;Rampazzo et al, 2012;Rodríguez-Vargas, 2013). In Iran, a study from Khuzestan province (in south of the country) showed a mean age of 60 years (Hajiani et al, 2006) subsequently a study from a referral center in Tehran showed mean age of 56 years (Abdi-Rad et al, 2006).…”

“…Sex ratio in our study was higher than some other studies (Newnham et al, 2003;Hajiani et al, 2006;Mousavi and Somi, 2009;Rampazzo et al, 2012;Aghaei et al, 2013;Rodríguez-Vargas, 2013) and what has been reported in Global Cancer Statistics (Jemal et al, 2011). …”

“…In contrast, the rate of cardiac cancer in other reports was less than ours including studies from Japan, Korea, and South America with a rate of 10% (Babaei et al, 2010) and from Brazil with 14.3% (Rampazzo et al 2012). Because there are a few western pattern of topography of gastric cancer, thus the trend overall might be reverse.…”

Immunohistochemical Expression of Her2 in Adenocarcinoma of the Stomach

“…In southern Brazil, GC is the fourth most common cancer in men (14,3/100,000) and the sixth in women (8,4/100,000) (6) . In the 25 years-period from 1986 to 2010, the prevalence of GC in the central region of Rio Grande do Sul State, the most southern Brazilian state, was 1.6% (19) . The HER1, HER2, HER3 and HER4 receptors (also known as erbB) were first identified in 1978.…”