Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years

Gordo, Sandra Lopez; Bettonica, C.; Miró, Mònica; Estremiana, Fernando; Aranda, Humberto; Farràn, Leandre

doi:10.1007/s12029-021-00641-x

Cited by 3 publications

(11 citation statements)

References 32 publications

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“…30 Lopez Gordo et al also indicated a relevance between Ki67 levels and overall survival, however there it was not associated with recurrence. 18 According to National Cancer Institute (Surveillance, Epidemiology and End Results: Localized, Regional a Distant), the 5-Year overall survival rate of all stages of GISTs including all primary tumor sites is 83% (28). Lopez Gordo et al reported that in patients with small intestine GISTs, 5-year disease-free survival was 65.7%, whereas it was 90.8% in patients with gastric GISTs.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the 5-year overall survival rates of patients with non-gastric and gastric GISTs were 61% and 72.3%, respectively. 18 Although absence of a consensus in the literature for the optimal negative resection margin length, surgical resections either as wedge, complete or simple excision with negative margins is still the first line of treatment for localized GIST. 18,25 In our series, of the five patients with positive surgical margins, two with macroscopic, and 1 with microscopic positive margins developed recurrence during the follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…18 Although absence of a consensus in the literature for the optimal negative resection margin length, surgical resections either as wedge, complete or simple excision with negative margins is still the first line of treatment for localized GIST. 18,25 In our series, of the five patients with positive surgical margins, two with macroscopic, and 1 with microscopic positive margins developed recurrence during the follow-up. Positive surgical margins were significantly associated with recurrence but no relation with mortality was observed.…”

Section: Discussionmentioning

confidence: 99%

“…17 On the other hand, in patients with resectable tumors, complete surgical resection with negative margins is the first-line treatment with favorable survival outcomes. 17,18 Despite their variable biological behavior, all GISTs have the potential to develop recurrence or metastatic diseases according to the characteristics of the primary tumor. [2][3][4][5][6][7][8][9][10] The prognosis of GISTs originating from the stomach is better compared with tumors arising from the small intestine, colon, rectum, or mesentery.…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal Stromal Tumors: Recurrence and Survival Analysis of 49 Patients

Çolapkulu

Gunel

Beyazadam

et al. 2023

Middle East J Dig Dis

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Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor originating from the gastrointestinal tract and have a broad spectrum of clinicopathological features affecting disease management regarding the treatment modalities. Methods: A retrospective study of 49 patients who underwent surgery for gastrointestinal tumors between 2008 and 2016 was conducted. Clinical, pathological, and immunohistochemical features of patients with and without recurrence were statistically analyzed.Results: Twenty-nine (59.1%) patients had gastric; 16 (32.6%) had small intestinal; 3 (6.1%) had mesenteric; and 1 (2.2%) had rectal GISTs. Microscopic tumor necrosis and tumor ulceration were also significant for disease recurrence (P = 0.005, P = 0.049). High-risk patients according to Miettinen’s risk classification were more likely to develop a recurrence (P < 0.001). Additionally, high-grade tumors were also a risk factor for recurrence (P < 0.001). Ki-67 levels were available in 40 patients and the mean Ki-67 level was 16.8 in patients with recurrence, which was a significant risk factor in regression analysis (HR: 1.24, 95%, CI: 1.08-1-43). Five-year disease-free survival rates of non-gastric and gastric GISTs were 62.3% and 90%, respectively (P = 0.044).Conclusion: Larger tumors and higher mitotic rates are more likely to develop recurrence. High Ki-67 levels were also associated with recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal Stromal Tumors: Recurrence and Survival Analysis of 49 Patients

Çolapkulu

Gunel

Beyazadam

et al. 2023

Middle East J Dig Dis

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“…However, existing studies have focused on the clinical presentations and conventional morphological imaging features between siGIST and GSTs (10,11) , and differences between siGISTs in various genotypes remain limited. Only one study investigated the contrast-enhanced CT (CECT) morphological imaging features between siGISTs with KIT exon 9 versus KIT exon 11 mutations (12) .…”

Section: Introductionmentioning

confidence: 99%

CT Radiogenomics for Differentiating KIT Exon 11 from non-KIT Exon 11 Gene Mutations in Small Intestinal Gastrointestinal Stromal Tumors

Yang,

Yin,

Che

et al. 2023

Preprint

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Backgroud This study aimed to explore the non-invasive differentiation of gene mutational subtypes of KIT exon 11 from non-KIT exon 11 in small intestinal gastrointestinal stromal tumors (siGISTs) using radiogenomics based on the contrast-enhanced CT (CECT) images. Materials and Methods Patients with primary siGISTs diagnosed by surgery and pathology at our hospital from May 2010 to December 2022 were retrospectively evaluated. The patients were randomly divided into a training set and a validation set with a ratio of 7:3. The synthetic minority oversampling technique algorithm was used by screening radiomics features and constructing models. Then, CECT, radiomics, and combined models are established. The performance of the three models was evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results This study included 91 siGISTs, including 59 (64.8%) with KIT exon 11 mutations and 32 (35.2%) with non-KIT exon 11 mutations. The diagnostic performance of the CECT model and radiomics model were sufficient, with the AUC values of its ROC curve being 0.746 and 0.869 in the training set, and 0.676 and 0.787 in the validation set, respectively. Additionally, the combined model composed of CECT and radiomics features has good performance, with AUC values of 0.882 (95% confidence interval [CI]: 0.828–0.937) and 0.618 (95% CI: 0.373–0.862), respectively. Conclusions The combined radiogenomics model based on CECT has the value of non-invasive differentiating KIT exon 11 from non-KIT exon 11 mutations in patients with siGISTs.

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Ruptured gastro-intestinal stromal tumor as a surgical emergency: A case report and literature review

Abdelgawad

Kamel

Issa

et al. 2022

Journal of Surgical Case Reports

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs of the small bowel are rare, and often present with an abdominal mass and/or bleeding. Chemotherapy and surgery are the mainstay of therapy. Here, we discuss an unusual case of a ruptured jejunal GIST with hemoperitoneum and recurrence despite surgical excision followed by Imatinib treatment. Forty-five cases of ruptured small intestinal GISTs were identified in the literature. Most cases were in males and were found to be at the site of the jejunum.

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Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years

Cited by 3 publications

References 32 publications

Gastrointestinal Stromal Tumors: Recurrence and Survival Analysis of 49 Patients

Gastrointestinal Stromal Tumors: Recurrence and Survival Analysis of 49 Patients

CT Radiogenomics for Differentiating KIT Exon 11 from non-KIT Exon 11 Gene Mutations in Small Intestinal Gastrointestinal Stromal Tumors

Ruptured gastro-intestinal stromal tumor as a surgical emergency: A case report and literature review

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