Gastric Angiomyolipoma: A Previously Undescribed Cause of Upper Gi Hemorrhage

Helwig, K.; Talabiska, David; Cera, Peter; Komar, Michael

doi:10.1111/j.1572-0241.1998.300_s.x

Cited by 13 publications

(4 citation statements)

References 4 publications

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“…A review of the literature yielded only three previously reported cases of AML in the gastrointestinal tract, but all of these were of the conventional morphologic type [24][25][26] (Table 2). They presented as submucosal masses measuring up to 3 cm in size, leading in two instances to ulceration of the overlying mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…Focally, melanin pigment was present in the cytoplasm of the tumor cells. Immunohistochemically, the tumor [26] 50 M Descending colon 3 cm pedunculated & ulcerated polyp Conventional Helwig et al, 1998 [24] 75 F Stomach 1.2 cm submucosal ulcerated mass Conventional This report, Case 1 6 F Appendix 1.3 cm transmural and intraluminal mass Pleomorphic This report, Case 2 22 F Cecum 3 cm transmural mass Pleomorphic cells were strongly positive for vimentin and HMB-45; focally positive for smooth muscle actin, desmin, and A103; and negative for the other markers tested (Figs. 8, 9, Table 1).…”

Section: Casementioning

confidence: 99%

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Pleomorphic Angiomyolipoma of Digestive Tract: A Heretofore Unrecognized Entity

et al. 2000

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Two cases of pleomorphic angiomyolipoma (AML) composed of bizarre epithelioid smooth muscle cells located in the gastrointestinal tract are reported. One involved the appendix of a 6-year-old girl, and the second the cecum of a 22-year-old woman. In both instances the tumor cells were immunoreactive for HMB-45 and A103. To the best of our knowledge, this peculiar variant of an AML has not previously been recognized in this location. Int J Surg Pathol 8(1):67-72, 2000

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Section: Discussionmentioning

confidence: 99%

Section: Casementioning

confidence: 99%

Pleomorphic Angiomyolipoma of Digestive Tract: A Heretofore Unrecognized Entity

et al. 2000

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“…Only few reports of the occurrence of extra-renal AML in the colon, stomach, and small bowel have been published. [13,[26][27][28][29] However, no reports of NF1 being accompanied by AML have been published, with only 1 case of renal AML reported to occur in segmental neurofibromatosis. [14] AML is a tumor composed of varying proportions of mature adipocytes, smooth muscle, and irregular blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Synchronous cutaneous malignant peripheral nerve sheath tumor and jejunal gastrointestinal stromal tumor and submucosal angiomyolipoma in type 1 neurofibromatosis: A case report and literature review

Kim

Rao

et al. 2023

Medicine

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Rationale: Type 1 neurofibromatosis (NF1) is one of the most prevalent genetic conditions. NF1 is characterized by cutaneous plexiform neurofibromas and café au lait skin pigmentation, and is inherited in an autosomal dominant trait with mutation in the neurofibromin 1 gene on chromosome 17. Neurofibromin is involved in Ras proto-oncogene regulation. Accordingly, NF1 may lead to malignancies, with a lifetime cancer risk of 60%. Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality due to NF1. The relevance of gastrointestinal stromal tumor (GIST) in NF1 is increasingly being reported in the literature and NF1-associated GIST has been identified to have an alternative molecular pathogenesis.Patient concerns: A 62-years-old female had a 7 × 5 cm growing back mass in the background of various sized cutaneous neurofibromas with café au lait spots. Computed tomography performed in the workup revealed a 4.1 cm enhancing mass near the ileal mesentery.Diagnoses: NF1 affected by cutaneous MPNST of the back, and synchronous GIST and submucosal angiomyolipoma (AML) of the jejunum. Interventions:The patient underwent laparoscopic jejunal mass excision, and excision and flap coverage for the back mass owing to the suspicion of multiple MPNSTs. However, the abdominal masses were diagnosed as GIST and AML following confirmation of the immunohistochemical profiles. Accordingly, the patient was administered adjuvant radiotherapy to the MPNST after surgery.Outcomes: Symptomatic improvements were achieved, and no subsequent relapses were observed.Lessons: Although MPNST and GIST are not rare neoplasm in NF1, only 2 case reports have been published on the synchronous occurrence of these tumors. Moreover, no case report has been published on AML in NF1, except 1 renal AML in segmental neurofibromatosis. Identifying the clinical and pathologic significances of the NF1 is important to achieve improved diagnostic accuracy.

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“…The unifying concept of a family of lesions characterized by the presence of perivascular epithelioid cells has been suggested (17). A review of the literature revealed three previously reported cases of angiomyolipoma in the gastrointestinal tract (18)(19)(20). They presented as submucosal masses measuring up to 3 cm, leading, in two instances, to ulceration of the overlying mucosa.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Tumor of the Colon in an 8.5‐Year‐Old Girl

Zolota,

Batistatou,

Melachrinou

et al. 2001

J. pediatr. gastroenterol. nutr.

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Gastric Angiomyolipoma: A Previously Undescribed Cause of Upper Gi Hemorrhage

Abstract: Angiomyolipomas are rare lesions often arising in the kidney. We describe the first documented case of symptomatic gastric angiomyolipoma.

Cited by 13 publications

References 4 publications

Pleomorphic Angiomyolipoma of Digestive Tract: A Heretofore Unrecognized Entity

Pleomorphic Angiomyolipoma of Digestive Tract: A Heretofore Unrecognized Entity

Synchronous cutaneous malignant peripheral nerve sheath tumor and jejunal gastrointestinal stromal tumor and submucosal angiomyolipoma in type 1 neurofibromatosis: A case report and literature review

Clear Cell Tumor of the Colon in an 8.5‐Year‐Old Girl

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