Gastric antiulcer effect of Rhizophora mangle L

Perera, Luz María Sánchez; Ruedas, Dayamı́; Gómez, Beatrı́z

doi:10.1016/s0378-8741(01)00277-x

Cited by 50 publications

(24 citation statements)

References 13 publications

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“…From a nutritional point of view, high tannins diets consumption leads to different episodes in humans and animals. Scientific references report evident correlation between dietary polyphenols rich diets and health enhancing properties: antioxidant properties [11][12][13], antibacterial activity on different bacterial strains in vitro and in vivo [7,[14][15][16][17][18][19][20], antiparasitic [21], antiulcerogenic [22][23][24] antidiarrhoic [25], antimutagenic [26][27][28][29][30][31][32][33], antitumor [34][35][36][37][38], and some neoplastic cell line apoptosis [39,40]. On the other hand, high tannins diets might also result in detrimental effects like hepatotoxicity [41,42], toxic nephrosis [43], oesphageal cancer [44], depression of feed intake and growth rate in many animal species [45][46][47][48][49][50][51].…”

Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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Proline contents of parotid glands (PG) in pigs constantly increase after the inclusion of different amounts of ripe hulled acorns in the diet providing high polyphenols levels. The dose-response relationship was estimated on natural hydrolizable tannins (expressed as tannic acid equivalent TAE) amounts of 25.8 to 36.1 g TAE/kg DM in experimental diets. Macroscopic and histological morphometry of parotid glands greatly varied according to feed intake and dosages of TAE ingested. The PG response (hypertrophy grade) on acorns' tannins content in the diet was positively correlated (R 2 = 0.748): the response to the protein precipitating activity (PPA) of tannins consisted of a functional parotidomegaly (hypertrophy), 1.34 up to 3.55 folds than control PGs, following an oral dosage 0.596 up 1.72 TAE g·kg -1 body weight·d -1 respectively, after one week exposure.

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Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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“…However, either plant crude extracts or their pure compounds are good sources for the development of new drugs and have been shown to produce promising results in the treatment of gastric ulcers (Hiruma-Lima et ). There are many works reporting the antiulcerogenic effect of both plant extracts and their pure compounds, such as: Perera et al (2001) on Rhizopora mangle (500 mg/kg), Suffredini et al (1999) on Microgramma squamulosa (400 mg/kg), Markman et al (2004) on Campomanesia xanthocarpa (400 mg/kg), Rodriguez et al (2003) on oleanolic acid (25, 50 and 100 mg/kg) isolated from Fabiana imbricata, and Jorge et al (2004) on Maytenus ilicifolia (320 mg/kg).…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Andrade

Antoniolli

Comunello

et al. 2006

Zeitschrift Für Naturforschung C

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Many plant crude extracts and their isolated compounds are the most attractive sources of new drugs and show promising results for the treatment of gastric ulcers. Austroplenckia populnea is commonly known as "marmelinho-do campo, mangabeira-brava, mangabarana and vime" and it has been used in folk medicine as anti-dysenteric and anti-rheumatic. Powdered bark wood (3.25 kg) was macerated with aqueous ethanol (96%) and the extract was concentrated under reduced pressure to yield 406 g of crude hydralcoholic extract. The hydralcoholic extract was suspended in aqueous methanol and partitioned with hexane, chloroform and ethyl acetate (EtOAc) in sequence, yielding 8.0 g, 9.5 g and 98.17 g of crude extracts, respectively. Chromatography of the hexane extract over a silica gel column led to the isolation of the triterpene populnoic acid. The oral administration of hydralcoholic, hexane, chloroform and EtOAc extracts (200 mg/kg) decreased the ulcer lesion index (ULI) by 83.15%, 46.87%, 32.2%, 68.12%, respectively. Oral administration of populnoic acid (100 mg/ kg) diminished the ULI by 55.29%. All the obtained results were significant in comparison with the negative control, with exception of the chloroform extract.

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“…In previous works, we reported the cytoprotective effect of freeze dried aqueous extract from red mangrove bark on gastric ulceration induced by ethanol-hydrochloric acid in rats [2]. Also, we report the antiulcerogenic effect by other action's mechanism as antisecretor, inhibitor of depleting of PGE2 in the gastricmucous and antioxidant [3] [4].…”

Section: Introductionmentioning

confidence: 70%

Further Pharmacological Evidence Supporting the Development of an Antiulcerogenic Drug Based on Rhizophora mangle L. Aqueous Extract. HPLC Method Proposed for Determinating a Chemical Marker

Perera¹,

Piloto²,

Canelsota³

et al. 2016

OALib

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Rhizophora mangle L. is a vegetal species with high disponibility in Cuba for guarantying economical factibility by drug development. Preview studies showed promissory pharmacological results by the use of this plant in the treatment of gastroduodenal ulcers. The present work involved another evaluation of the active extract important by the development of a new drug. It was evaluated by intestinal absorption in vitro and in situ models and anti-diarrheic activity in rats. The polyphenolic fractions were separated from the aqueous extract and its cytoprotective activity was studied on gastric ulceration induced by ethanol plus hydrochloric acid in rats. Some toxicological studies were carried out. We made a validation of HPLC method by the analysis of one mark in the tablet development. The aqueous extract showed high absorption, and high anti-diarrheic effect. The low-molecular weight polyphenolic fraction showed the highest level of gastric protection. No toxicological signs were obtained by it. HPLC method evidenced linearity, precision, sensitivity and accuracy.

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Gastric antiulcer effect of Rhizophora mangle L

Cited by 50 publications

References 13 publications

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Further Pharmacological Evidence Supporting the Development of an Antiulcerogenic Drug Based on Rhizophora mangle L. Aqueous Extract. HPLC Method Proposed for Determinating a Chemical Marker

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