Gastric B-cell mucosa associated lymphoid tissue lymphoma: a clinicopathological study in 56 patients.

Castrillo, J. M.; Montalbán, Carlos; Obeso, G; Piris, Miguel Á.; Rivas, Marinha Costa

doi:10.1136/gut.33.10.1307

Cited by 36 publications

(18 citation statements)

References 31 publications

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“…Montalban et al [5] found that complete remission had been achieved in 91% of patients in the low-grade group, but was substantially [4] found that patients with low-grade lymphoma had a 100% actuarial survival at 156 months, which was significantly better than that of 52% recorded for patients in the high-grade group. These researchers suggested that the prognosis of gastric lymphoma depended primarily on the histologic grade and stage, which are closely related.…”

Section: Discussionmentioning

confidence: 93%

“…The distinctive low-grade B-cell MALT lymphoma of the stomach has been well characterized [4][5][6][7][8][9][10][12][13][14][15], but its relationship with the more commonly occurring large B-cell gastric lymphoma and the histologic classification of gastric lymphoma has not been clarified. Isaacson and Wright [3] classified primary B-cell lymphoma of MALT into low-grade and high-grade lymphomas with or without evidence of a lowgrade component.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphomas arising in these specific areas exhibit a biologic behavior that differs from that of nodal lymphomas and are classified as low-grade or high-grade at histology [2,3]. In the low-grade MALT lymphoma, the small neoplastic cells possess irregular nuclei (centrocytelike), and glandular invasion is a prominent feature [4][5][6]. In the high-grade MALT lymphoma, the blasts occur in clusters or sheets and often possess plasmacytic cytoplasm; glandular invasion is a rare event [4][5][6].…”

mentioning

confidence: 99%

“…Since the classification of MALT lymphoma by Isaacson and Wright in 1988 [3], other researchers have found that patients with low-grade, as opposed to high-grade, MALT lymphoma have a favorable prognosis with a higher rate of complete remission and survival [4][5][6][7]. Moreover, the therapeutic approach is different for the two lymphomas [8,9].…”

mentioning

confidence: 99%

“…In the low-grade MALT lymphoma, the small neoplastic cells possess irregular nuclei (centrocytelike), and glandular invasion is a prominent feature [4][5][6]. In the high-grade MALT lymphoma, the blasts occur in clusters or sheets and often possess plasmacytic cytoplasm; glandular invasion is a rare event [4][5][6].…”

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confidence: 99%

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Radiographic Findings of Primary B-Cell Lymphoma of the Stomach: Low-Grade Versus High-Grade Malignancy in Relation to the Mucosa-Associated Lymphoid Tissue Concept

Park

Kim

et al. 2002

American Journal of Roentgenology

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OBJECTIVE. We undertook this study to assess how well double-contrast radiography and CT allow radiologists to differentiate low-grade from high-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach. MATERIALS AND METHODS.We retrospectively reviewed the upper gastrointestinal radiographs and contrast-enhanced CT scans of 57 patients with pathologically proven primary gastric lymphoma (low-grade [ n = 29] and high-grade [ n = 28] MALT lymphoma).RESULTS. On upper gastrointestinal radiography, ulceration (39%) was the most common finding in low-grade lymphoma, whereas polypoid appearance (38%) was the most common in high-grade lymphoma. In the 29 patients (33 lesions) with low-grade MALT lymphoma, upper gastrointestinal radiography revealed 13 ulcerative lesions (39%), 10 nodular lesions (30%), four infiltrative lesions (12%), two polypoid lesions (6%), and four combined lesions (12%). In the 28 patients (29 lesions) with high-grade lymphoma, upper gastrointestinal radiography revealed 11 polypoid lesions (38%), nine infiltrative lesions (31%), six ulcerative lesions (20%), one nodular lesion (3%), and two combined lesions (7%). On CT, thickening of the gastric wall in low-grade lymphoma (range, 0.3-2.5 cm; mean, 0.8 cm) was much less than that in high-grade lymphoma (range, 0.7-8.0 cm; mean, 2.5 cm). Abdominal lymphadenopathy was less frequent in low-grade lymphoma (14%) than in high-grade lymphoma (75%).CONCLUSION. Most low-grade lymphomas show superficial spreading lesions, such as mucosal nodularity, shallow ulcer, and minimal fold thickening, on upper gastrointestinal radiography, whereas most high-grade lymphomas show mass-forming lesions or severe fold thickening.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Radiographic Findings of Primary B-Cell Lymphoma of the Stomach: Low-Grade Versus High-Grade Malignancy in Relation to the Mucosa-Associated Lymphoid Tissue Concept

Park

Kim

et al. 2002

American Journal of Roentgenology

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Reassessment of gastric lymphoma in light of the concept of mucosa-associated lymphoid tissue lymphoma

Hoshida

Kusakabe

Furukawa

et al. 1997

Cancer

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Primary gastric lymphoma. A clinicopathologic study of 233 cases with special reference to evaluation with the MIB-1 index

Nakamura

Akazawa

Yao

et al. 1995

Cancer

108

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Background. Few articles have analyzed the prognostic data from a large series of primary gastric lymphoma classified according to the concept of mucosa‐associated lymphoid tissue (MALT). Methods. The resected specimens from 233 patients with primary gastric lymphoma were investigated retrospectively, including immunostaining with MIB‐1 (Ki‐67). Results. Histologically, 70 (30%) of the cases were low grade B‐cell lymphoma of MALT, 27 (12%) low grade B‐cell lymphoma of MALT with a focal high grade component, 100 (43%) high grade B‐cell lymphoma of MALT, 15 (6%) other B‐cell lymphomas, 14 (6%) T‐cell lymphomas, and 7 (3%) undetermined. Macroscopically, 96 (41%) were superficial‐spreading type, 100 (43%) mass‐forming, 14 (6%) diffuse‐infiltrating, and 23 (10%) unclassified. The MIB‐1 index correlated with phenotype, histologic grade, stage, depth of invasion, and macroscopic type. A significantly better survival was noted for young patients, and those with tumors of a B‐cell phenotype, histologic low grade, macroscopic superficial‐spreading type, low stage, low depth of invasion, and low MIB‐1 index. No significantly different survival rates were found between the patients who underwent gastric resection alone and those who also received additional chemotherapy. By Cox multivariate analysis, independent prognosticators included B‐cell phenotype, low stage, and macroscopic superficial‐spreading type. Conclusions. In addition to stage, phenotype and macroscopic type are also important prognostic indicators of primary gastric lymphoma. Immunostaining with MIB‐1 had limited independent value for predicting prognosis.

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Gastric B-cell mucosa associated lymphoid tissue lymphoma: a clinicopathological study in 56 patients.

Abstract: Clinico-pathological features of 56 patients with primary gastric lymphoma were evaluated

Cited by 36 publications

References 31 publications

Radiographic Findings of Primary B-Cell Lymphoma of the Stomach: Low-Grade Versus High-Grade Malignancy in Relation to the Mucosa-Associated Lymphoid Tissue Concept

Radiographic Findings of Primary B-Cell Lymphoma of the Stomach: Low-Grade Versus High-Grade Malignancy in Relation to the Mucosa-Associated Lymphoid Tissue Concept

Reassessment of gastric lymphoma in light of the concept of mucosa-associated lymphoid tissue lymphoma

Primary gastric lymphoma. A clinicopathologic study of 233 cases with special reference to evaluation with the MIB-1 index

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