Gastric Calcifying Fibrous Tumor: A Very Rare Case Report

Vasilakaki, Thivi; Skafida, E; Tsavari, Aikaterini; Arkoumani, E.; Koulia, Kalliroi; Myoteri, Despoina; Grammatoglou, Xanthippi; Moustou, Eleni; N, Firfiris; Zisis, Dimitrios

doi:10.1159/000342137

Cited by 16 publications

(12 citation statements)

References 10 publications

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“… 3 , 6 , 18 , 39 – 49 Intrabdominal CFTs present with a great variety of symptoms, both general and more specific. 10 , 11 , 16 , 20 , 21 , 23 , 27 , 44 , 50 – 75 Lack of appetite, fever, weight loss, fatigue, and progressive weakness are examples of general symptoms. More specific ones are dyspepsia, flatulence, halitosis, nausea, vomiting, red blood per rectum, and altered bowel habits.…”

Section: Discussionmentioning

confidence: 99%

Calcifying Fibrous Tumor

2016

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Calcifying fibrous tumor (CFT) is a benign lesion characterized by its specific histological findings and is found as solitary or multiple lesions in several locations of the human body. The aim of the present systematic review is to give a detailed account of all reported cases of CFT in the literature and to analyze the available data, to completely characterize the entity from epidemiological, medical, and surgical aspects.A bibliographic research was performed from 1988 until 2015. A database with the patients’ characteristics was made, including sex, age, location of the tumor, symptoms, symptoms duration, size of the tumor, diagnostic methods, treatment, metastasis, and follow-up.A total of 104 articles were identified, reporting 157 cases of CFT. Mean age of patients was 33.58 years and the ratio between men and women was 1:1.27. The most common locations of CFT were stomach (18%), small intestine (8.7%), pleura (9.9%), mesentery (5%), and peritoneum (6.8%). Mean diameter of the tumor was estimated 4.6 cm. The correlations proceeded showed that as age increases, size decreases (P = 0.001) and that the tumor is larger in females (P = 0.027). Kruskal-Wallis test showed that the larger tumors appear in the neck and adrenal gland (P = 0.001). The percentage of asymptomatic patients was 30.57%. Computed tomography and biopsy were the most common tests for the diagnosis of CFT. Open surgical procedure was performed in the majority of cases. The median hospitalization was 6.06 days and the mean follow-up period was 29.97 months. Recurrences were mentioned in 10 of 96 patients with available data. No deaths owing to CFT were mentioned in the literature.CFT should be included in the differential diagnosis of enlarging mass revealed by clinical or imaging examination either incidentally or after specific acute or chronic symptomatology.

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Section: Discussionmentioning

confidence: 99%

Calcifying Fibrous Tumor

2016

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“…Only a few case series exist. The most commonly involved sites are the stomach [3][4][5][6][7][8][9][10][11][12][13][14][15][16] and small intestine. 3,4,6,14,[17][18][19][20][21][22][23][24][25] Three examples in the large intestine exist 14,17,26 and a single case in the esophagus.…”

Section: Clinical and Imaging Findingsmentioning

confidence: 99%

“…6,16,19,28 Although generally well circumscribed, CFTs are unencapsulated and may extend between layers of the GI tract wall, splaying apart muscle bundles. 13,15,16 Peripheral entrapment of small nerves and adipocytes is only rarely described. 12 …”

Section: Clinical and Imaging Findingsmentioning

confidence: 99%

“…Immunohistochemically, the spindle cells stain strongly and diffusely for vimentin 7,17 and factor XIIIa ( Figure, D). 7,8,15 Reactivity with other immunostains, including smooth muscle actin, CD68, desmin, and CD34, is variable and often patchy. Recent studies 16,22 have also highlighted that many of the plasma cells in CFT are positive for IgG and IgG4.…”

Section: Ancillary Studiesmentioning

confidence: 99%

“…27 Calcifying fibrous tumors in the stomach have been treated by wedge resection. 5,9,15,16 Intestinal examples have been predominantly treated by segmental resection, although enucleation has also been performed. 21 Calcifying fibrous tumor is considered benign and cured by local removal, although rare recurrences have been noted in extra-GI lesions.…”

Section: Treatment and Prognosismentioning

confidence: 99%

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Calcifying Fibrous Tumor of the Gastrointestinal Tract

Larson¹,

Dhall

2015

Archives of Pathology &Amp; Laboratory Medicine

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Calcifying fibrous tumor is a benign mass lesion classically described as a soft tissue tumor. However, a thorough review of the literature reveals that it can occur virtually anywhere, including the tubular gastrointestinal (GI) tract. Its clinical manifestations are variable in the GI tract, and its imaging findings are nonspecific. However, it has unique histologic and immunophenotypical features that must be recognized by GI pathologists to differentiate it from an assortment of other rare mesenchymal lesions of the abdomen and GI tract. Calcifying fibrous tumor is composed of a paucicellular collagen matrix, interspersed calcified bodies, and a sparse inflammatory infiltrate. Although calcifying fibrous tumor is benign, pathologists must be aware that it may occur in the GI tract to differentiate it from other potentially more aggressive, rare mesenchymal lesions.

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Gastric calcifying fibrous tumors

Wang

Mao

et al. 2021

Medicine

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To retrospectively analyze the computed tomography (CT) findings and clinical manifestations of gastric calcifying fibrous tumor (CFTs). The features of 7 cases with pathologically proven gastric CFTs who had undergone CT were assessed, including tumor location, contour, growth, degree of enhancement, calcification and clinical data. In addition, the size and CT value of each lesion were measured. The mean values of these CT findings and clinical data were statistically analyzed only for continuous variables. Four patients were female and three were male (mean age: 33.3 years; range: 22 ∼ 47 years). Nonspecific clinical symptoms: abdominal pain and discomfort were observed in four cases and the CFTs were incidentally detected in the other three cases. Regarding tumor markers, lower ferritin levels were observed in three female patients. All of the gastric CFTs were solitary and mainly located inside the body; they were in round or oval shape and exhibited endophytic growth. Gastric CFTs are usually small sized and could contain confluent and coarse calcifications; cyst, necrosis, ulcer, bleeding and surrounding lymphadenopathy were not found in any of the cases. Unenhanced CT values of gastric CFTs were higher than those of same-transect soft tissue. Mild-to-moderate enhancement in the arterial phase and progressive enhancement in the portal venous phase were mainly noted. A gastric mass with a high unenhanced CT attenuation value, confluent and coarse calcifications and mild-to-moderate enhancement could prompt a diagnosis of gastric CFT. In addition, (1) being young- or middle-aged, (2) having relatively low ferritin levels, and (3) tumor located in the gastric body have critical reference value for diagnosis of gastric CFT.

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Gastric Calcifying Fibrous Tumor: A Very Rare Case Report

Cited by 16 publications

References 10 publications

Calcifying Fibrous Tumor

Calcifying Fibrous Tumor

Calcifying Fibrous Tumor of the Gastrointestinal Tract

Gastric calcifying fibrous tumors

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