Gastric Cancer: How Can We Reduce the Incidence of this Disease?

Hoed, Caroline M. den; Kuipers, Ernst J.

doi:10.1007/s11894-016-0506-0

Cited by 140 publications

(101 citation statements)

References 64 publications

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“…7 Smoking and alcohol are also risk factors for GC. 11 However, in the present study, no correlation between a positive history of smoking or alcohol consumption and the incidence of synchronous GC in patients with HNSCC was shown and it might be attributed to the too low number of patients with synchronous GC. A previous study showed that synchronous esophageal SCC was detected in patients with HNSCC located in the pharynx and hypopharynx.…”

Section: Discussioncontrasting

confidence: 83%

“…8 Histologically, most GCs are adenocarcinoma, and the risk factors for GC are Helicobacter pylori infection and certain life habits, such as salty diet, smoking, and alcohol consumption. 11 GC is the second most common cancer in Korea followed by thyroid carcinoma; 10 however, the incidence of synchronous GC in patients with HNSCC has not been reported to date. In the present study, we investigated the incidence of synchronous GC …”

mentioning

confidence: 99%

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Incidence of Gastric Cancer in Patients with Laryngeal Cancer

Seo

Kim

Park

et al. 2017

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: Gastric cancer (GC) is the second most common cancer in Korea and the most common in men in the south of the country. We investigated the incidence of synchronous GC in patients with head and neck squamous cell carcinoma (HNSCC) in the southern part of Korea. Materials and Methods: We retrospectively reviewed the medical records of HNSCC patients treated between 2011 and 2014. In patients with synchronous GC, evaluation included a history of smoking and alcohol consumption, endoscopic findings, Campylobacter-like organism (CLO) test, and immunohistochemical analysis of preserved HNSCC tissues. Results: Analysis of the records of 153 HNSCC patients revealed tumors of the larynx in 56 patients (36.6%), of the pharynx in 74 patients (48.4%), and tumors at other locations in 23 patients (15.0%). The mean age of patients was 66.0 years, and the men:women ratio was 8:1. Synchronous cancers were detected in 12 patients. We observed esophageal squamous cell carcinoma (SCC) in five patients (3.3%), and gastric adenocarcinoma in seven patients (4.6%). Synchronous GC was detected in patients with laryngeal SCC. All cases of GC were classified as early GC. Conclusions: Synchronous GC was as frequent as esophageal SCC in patients with HNSCC, and all cases of GC were observed to be early stage cancers in this study. Thorough endoscopic examination should be performed in patients with laryngeal cancer to de-

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Section: Discussioncontrasting

confidence: 83%

mentioning

confidence: 99%

Incidence of Gastric Cancer in Patients with Laryngeal Cancer

Seo

Kim

Park

et al. 2017

Korean J Helicobacter Up Gastrointest Res

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“…Non-cardia intestinal adenocarcinomas probably develop via a specific pathway that starts with chronic gastritis, which leads to gland loss, development of atrophic gastritis, intestinal metaplasia and dysplasia culminating in gastric adenocarcinoma15 (table 1). Apparently, infection of H. pylori is not the only determinant of gastric cancer incidence and other factors play an important role 16. In the current review, we will discuss the recent advances in our understanding of the molecular events that cause gastric cancer and the new emerging targets for therapeutic intervention.…”

Section: Introductionmentioning

confidence: 99%

Gastric cancer: somatic genetics as a guide to therapy

Zhang

2016

J Med Genet

133

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Gastric cancer is the leading cause of cancer-related mortality across the world, with poor prognosis and a median overall survival of ≤12 months for advanced stage gastric cancer. Environmental, genetic and other predisposing factors contribute to the development of gastric cancer and a predominant factor was found to be infection of Advances in understanding the deranged signalling pathways that are critical for normal cellular homeostasis helped in the development of novel drugs that target specific proteins and pathways to curtail the growth of gastric cancer. Genetic studies revealed several single nucleotide polymorphisms, chromosomal aberrations and epigenetic alterations that likely play a major role in elevating the susceptibility to develop gastric cancer. Methylation pattern of specific genes may likely prove to be a valid biomarker for early detection of gastric cancer, but much progress is needed to establish specific markers. Important developments have been made in targeting human epidermal growth factor receptor-2 and vascular endothelial growth factor receptor 2 for treating advanced gastro-oesophageal junction cancer, using specific monoclonal antibodies. Lack of efficacy with regard to targeting other signalling pathways including mesenchymal-epithelial transition/hepatocyte growth factor and mammalian target of rapamycin is probably due to suboptimal patient selection for these clinical trials, which is probably due to the lack of appropriate biomarkers, to decide on responsive patient population. Besides the development of antagonists for the cell growth-related signalling pathways, advances are also being made to tackle gastric cancer by immunotherapies, targeting immune check-points, which may hold promise for better treatment options in future.

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“…Like other solid malignancies of gastrointestinal origin, gastric cancer is curable when diagnosed in its early stage of development . Given its population's high incidence of GC and the life‐saving benefit of early detection, South Korea's National Cancer Screening Program recommends screening by upper endoscopy (UE) or upper gastrointestinal (UGI) series every other year starting at 40 years of age . The endoscopic evaluation based on the stomach lining examination, alone or by combination with biopsy, can help predict risks and guide therapeutic intervention .…”

Section: Introductionmentioning

confidence: 99%