Gastric cancer in India

Pavithran, Keechilat; Doval, D.C.; Pandey, Kavita

doi:10.1007/s101200200042

Cited by 34 publications

(28 citation statements)

References 13 publications

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“…Also, H. pylori from India has been resistant to commonly prescribed drugs, like metronidazole (19). Due to an extremely high rate of colonization, the incidence of gastroduodenal diseases linked to H. pylori, such as gastric-duodenal ulcers and stomach cancer, is thought to be very high, but these incidence rates have been grossly underestimated as low to negligible (22). Genetic analyses have been carried out recently on isolates recovered from different Indian populations (2,7,15,19).…”

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confidence: 99%

Comparing Genomes of Helicobacter pylori Strains from the High-Altitude Desert of Ladakh, India

et al. 2005

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The genomic diversity of Helicobacter pylori from the vast Indian subcontinent is largely unknown. We compared the genomes of 10 H. pylori strains from Ladakh, North India. Molecular analysis was carried out to identify rearrangements within and outside the cag pathogenicity island (cag PAI) and DNA sequence divergence in candidate genes. Analyses of virulence genes (such as the cag PAI as a whole, cagA, vacA, iceA, oipA, babB, and the plasticity cluster) revealed that H. pylori strains from Ladakh are genetically distinct and possibly less virulent than the isolates from East Asian countries, such as China and Japan. Phylogenetic analyses based on the cagA-glr motifs, enterobacterial repetitive intergenic consensus patterns, repetitive extragenic palindromic signatures, the glmM gene mutations, and several genomic markers representing fluorescent amplified fragment length polymorphisms revealed that Ladakhi strains share features of the Indo-European, as well as the East Asian, gene pools. However, the contribution of genetic features from the Indo-European gene pool was more prominent.

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Comparing Genomes of Helicobacter pylori Strains from the High-Altitude Desert of Ladakh, India

et al. 2005

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“…2 In India the rate of incidence is less compare to the world. 3 It is fifth common in males and seventh common cancer in females in India. Although incidence is decreasing worldwide but in India especially in some states it is still increasing.…”

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confidence: 99%

Palliative surgery in management of advanced carcinoma stomach and its outcome

Pattanayak¹,

Saha²,

Bara³

et al. 2016

Int Surg J

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Background:Gastric cancer is the second leading cause of death from malignant disease World-wide and most frequently discovered in advanced stages. The incidence of gastric cancer in India is low compared to developed countries. But in India southern and northeast area more number of cases was diagnosed. More cases of cancer stomach are diagnosed in the early stages in Japan due to effective screening programme. Lack of such screening programme, ignorance about the disease and lack of awareness of warning signs of cancer lead to the detection of many cases in the advanced stage of gastric cancer. Where palliation is the mainstay of treatment. We discussed the different methods of palliative surgery and its outcome in this paper. Methods: This is a prospective study over 5 years February 2011 - 2016 January including 6 months follow up. 104 advanced carcinoma stomach patients were included in this study. To evaluate role of palliative surgery in advanced gastric cancer we analyse the data in the basis of presentation of disease, sex distribution, type of palliative surgery, relive of symptoms, preventions of complications, post-operative mortality morbidity, and overall survival.Results:In our study mean age of presentation is 58 years. Most common affected are male. Stage III disease are more common. Immediate post-operative mortality is 4 patients 7.14% comparable to the non-resection group 1 patients (2.63%). Symptoms relived 46 patients in resection group (82.14%), in non-resection group it is 16 (42.1%). Overall survival is (6 moths - 1 years) 19 (33.9%) patients, and in non-resection group it is only 2 (5.26%) patients. Median survival rate is 10 months.Conclusions:Palliative resection should be carried out for betterment of quality of life where it is possible. Relief from symptoms and complications can be achieved by resection of tumour mass in advanced carcinoma stomach.

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“…However, this is not seen in certain parts of India. 4 Age range for gastric carcinoma is 35-55 years in the South India and 45-55 years in the North India. The Age-Adjusted Rate (AAR) of gastric carcinoma among urban registries in India is (3.0-13.2) compared to the worldwide AAR (4.1-95.5).…”

Section: Introductionmentioning

confidence: 99%

“…The Age-Adjusted Rate (AAR) of gastric carcinoma among urban registries in India is (3.0-13.2) compared to the worldwide AAR (4.1-95.5). [4][5][6][7] Invasion and metastasis are the biologic hallmarks of the malignant tumor. 8 Hypercholesterolemia and hypertriglyceridemia helps in metastasis of tumor cells by promoting invasion of blood vessels and lymphatic channels.…”

Section: Introductionmentioning

confidence: 99%