2021
DOI: 10.1159/000512833
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Gastric Cancer Microbiome

Abstract: Identifying a microbiome pattern in gastric cancer (GC) is hugely debatable due to the variation resulting from the diversity of the studied populations, clinical scenarios, and metagenomic approach. <i>H. pylori</i> remains the main microorganism impacting gastric carcinogenesis and seems necessary for the initial steps of the process. Nevertheless, an additional non-<i>H. pylori</i> microbiome pattern is also described, mainly at the final steps of the carcinogenesis. Unfortunately, m… Show more

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Cited by 22 publications
(23 citation statements)
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“…Another example of a microorganism involved in the pathogenesis of GC is the genus Prevotella . These anaerobic gram-negative pleomorphic rods have been detected as one of the dominant species in GC patient samples [ 124 , 125 , 126 ]. More specifically, there are two representatives of this type: Prevotella acnes and Prevotella copri .…”
Section: The Role Of Selected Microorganisms and Immunity In The Deve...mentioning
confidence: 99%
“…Another example of a microorganism involved in the pathogenesis of GC is the genus Prevotella . These anaerobic gram-negative pleomorphic rods have been detected as one of the dominant species in GC patient samples [ 124 , 125 , 126 ]. More specifically, there are two representatives of this type: Prevotella acnes and Prevotella copri .…”
Section: The Role Of Selected Microorganisms and Immunity In The Deve...mentioning
confidence: 99%
“…However, in direct contrast, long-term H. pylori infection leads to hypochlorhydria due to decreased H + secretion by the parietal cells and this allows the growth of several other bacteria (discussed later) ( McColl et al, 1998 ). This cascade of events leads to atrophic gastritis, which eventually progresses to intestinal metaplasia, intraepithelial neoplasia, and GC ( Barra et al, 2021 ).…”
Section: Helicobacter Pylori : Our Friendly Foe Since Ancien...mentioning
confidence: 99%
“…On the other hand, GC patients from China had enrichment of species such as Slackia exigua, Streptococcus anginosus, Peptostreptococcus stomatis, Dialister pneumosintes , and Parvimonas micra in the stomach ( Coker et al, 2018 ). Furthermore, an overgrowth of nitrate-reducing bacteria in the atrophic stomach is attributed to the development of gastric cancer via the accumulation of N-nitroso compounds ( Barra et al, 2021 ).…”
Section: The Rewards and Penalties From The Microbial World Inside Usmentioning
confidence: 99%
“…Higher metabolites produced by dysbiosis of the gut microbiome, such as N-nitroso compounds and lactate, are thought to affect the immunological response as well as DNA damage, resulting in gastric carcinogenesis [ 75 , 76 ]. Recent studies proved that gut microbiota plays a significant role in the progression of gastric inflammation, AG, and IM after H. pylori eradication [ 77 , 78 ]. However, retrospective and only association-based findings are the limitations of these studies.…”
Section: Risk Modulation Of Gc By Co-existence Of Gut Microbiota and Infestation With Intestinal Helminthsmentioning
confidence: 99%