Gastric carcinoma in children

McGill, Terrance; Downey, E; Westbrook, Jules A.; Wade, David S.; Garza, Jaime de la

doi:10.1016/0022-3468(93)90120-a

Cited by 61 publications

(43 citation statements)

References 12 publications

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“…A brief literature review showed around ten cases reported in patients under the age of 5 years since 1978 [2][3][4][5]. Here, we report a patient suffering from primary adenocarcinoma of the stomach at age 30 months.…”

Section: Introductionmentioning

confidence: 94%

Primary gastric adenocarcinoma in a 2.5-year-old girl

et al. 2002

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anemia (hemoglobin [Hb], 2.6 g/l; hematocrit [Htc], 7) of the child was treated. Routine laboratory test results were nonspecific. Serum tumor markers, such as carcinoembryonic antigen alpha-fetoprotein, antigen (CEA), and human chorionic gonadotropin (HCG) were negative. Her blood group was B rh (ϩ). She came from a family of six children living in a rural mountain area. The family history of the child was not informative. There was no history of childhood tumor or gastrointestinal malignancies in the family and close relatives. However, several gastrointestinal infections had frequently occurred in the family.At surgery, we found a large, irregularly circumferential solid mass, extending from the corpus to 1.5 cm below the pylorus, originating from the lesser curvature. There was a firm extension to the omentum and the abdominal wall. The stomach outside the mass invasion had a normal appearance. The liver and other intraperitoneal organs appeared free of gross disease. Complete resection of the mass and a subtotal gastrectomy (80%) was performed. A retrocolic gastrojejunostomy and omentectomy, removing all gross disease, completed the procedure. The resected specimen was a dark brown mass, 12 ϫ 7 ϫ 7cm in diameter, which had almost obliterated the gastric lumen. The intraluminal part of the mass had a soft, grayish, highly fragile nodular form in which gross mucous areas were remarkable. Lymph nodes in the area appeared normal, and representative biopsies were free of tumor.Microscopically, tumoral infiltration through the gastric wall was seen. We observed glandular structures presenting atypical epithelial cells, atypical mitosis, abundant eosinophylic cytoplasm, and highly hyperchromatic cells, and some large extracellular mucin-containing areas among these structures. Immunochemical staining of the specimen for epithelial membrane antigen (EMA) was positive, and staining for vimentin, smooth muscle actin, and alpha-fetoprotein was negative. The histological diagnosis, according Abstract Primary gastric adenocarcinoma is extremely rare in children. Here, we report an additional case of primary adenocarcinoma, located at the lesser curvature in a girl at the age of 2.5 years. She had no family history and no apparent underlying cause for the tumor. She died 4 months after admission despite complete resection of the mass and chemotherapy.

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Section: Introductionmentioning

confidence: 94%

Primary gastric adenocarcinoma in a 2.5-year-old girl

et al. 2002

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“…Role of chemotherapy and radiation is not well defined. Although some new studies in adult may support the use of etoposide, doxorubicin and cisplatin as primary therapy or combined with surgery and radiation 19 Any young patient present with persistent features of peptic ulcer disease should be evaluated for gastric malignancy. We can avoid delay in diagnosis by early upper gastroendoscopy with biopsy and barium meal.…”

Section: Discussionmentioning

confidence: 99%

Signet-Ring cell carcinoma of stomach in 13years old boy

Satti¹,

Bhatti²,

Ali³

2013

Int Jour of Biomed Res

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“…Carcinomas are extremely rare [7,20]. Since 1960, about 20 cases have been reported in patients younger than 21 years of age [7], and although there are some other reports in the medical literature, the number of patients is limited.…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, the annual incidence of all malignant tumors in children is thought to be 9-12/100 000 [7,20]. It is estimated that cancer of the gastrointestinal tract accounts for less than 5% of all pediatric neoplasms.…”

Section: Discussionmentioning

confidence: 99%