Gastric disorders: modifications of gastric content, antacids and drugs influencing gastric secretions and motility

Whitman, Zoë; O'Neil, Daniel H.R.

doi:10.1016/j.mpaic.2017.10.011

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Moon and Chun [ 16 ] reported three clinical cases of patients who used fentanyl without a correct prescription. The inadequate use of opioids leads to side-effects, such as alterations in pyramidal physiology [ 17 ], apnea, hypoxia, respiratory depression [ 11 , 18 ], constipation, nausea, vomiting, and reflux [ 19 , 20 ]. In this study, we observed that oxycodone and naloxone did not alter cell viability.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Neurotoxic Effects of Oxycodone and Naloxone in SH-SY5Y Cell Line

Lima¹,

Costa²,

Galiciolli³

et al. 2023

IJMS

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Opioid drugs have analgesic properties used to treat chronic and post-surgical pain due to descending pain modulation. The use of opioids is often associated with adverse effects or clinical issues. This study aimed to evaluate the toxicity of opioids by exposing the neuroblastoma cell line (SH-SY5Y) to 0, 1, 10, and 100 µM oxycodone and naloxone for 24 h. Analyses were carried out to evaluate cell cytotoxicity, identification of cell death, DNA damage, superoxide dismutase (SOD), glutathione S-transferase (GST), and acetylcholinesterase (AChE) activities, in addition to molecular docking. Oxycodone and naloxone exposure did not alter the SH-SY5Y cell viability. The exposure to 100 µM oxycodone and naloxone significantly increased the cells’ DNA damage score compared to the control group. Naloxone exposure significantly inhibited AChE, GST, and SOD activities, while oxycodone did not alter these enzymes’ activities. Molecular docking showed that naloxone and oxycodone interact with different amino acids in the studied enzymes, which may explain the differences in enzymatic inhibition. Naloxone altered the antioxidant defenses of SH-SY5Y cells, which may have caused DNA damage 24 h after the exposure. On the other hand, more studies are necessary to explain how oxycodone causes DNA damage.

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Section: Discussionmentioning

confidence: 99%

Assessment of Neurotoxic Effects of Oxycodone and Naloxone in SH-SY5Y Cell Line

Lima¹,

Costa²,

Galiciolli³

et al. 2023

IJMS

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Gastroprotective action of the ethanol extract of Leonurus sibiricus L. (Lamiaceae) in mice

Biano

Oliveira

Palmeira

et al. 2022

Journal of Ethnopharmacology

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Human Health Effects of Lactose Consumption as a Food and Drug Ingredient

Seoane

García-Recio

Garrosa

et al. 2020

CPD

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: Lactose is a reducing sugar consisting of galactose and glucose, linked by a β (1→4) glycosidic bond, considered as an antioxidant due to its α-hydroxycarbonyl group. Lactose is widely ingested through the milk and other unfermented dairy products and is considered to be one of the primary foods. On the other hand, lactose is also considered as one of the most widely used excipients for the development of pharmaceutical formulations. In this sense, lactose has been related to numerous drug-excipient or drug-food pharmacokinetic interactions. : Intolerance, maldigestion and malabsorption of carbohydrates are common disorders in clinical practice, with lactose-intolerance being the most frequently diagnosed, afflicting 10% of the world’s population. Four clinical subtypes of lactose intolerance may be distinguished, namely lactase deficiency in premature infants, congenital lactase deficiency, adult-type hypolactasia and secondary lactase intolerance. An overview of the main uses of lactose in human nutrition and in the pharmaceutical industry and the problems derived from this circumstance are described in this review.

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Gastric disorders: modifications of gastric content, antacids and drugs influencing gastric secretions and motility

Cited by 3 publications

References 4 publications

Assessment of Neurotoxic Effects of Oxycodone and Naloxone in SH-SY5Y Cell Line

Assessment of Neurotoxic Effects of Oxycodone and Naloxone in SH-SY5Y Cell Line

Gastroprotective action of the ethanol extract of Leonurus sibiricus L. (Lamiaceae) in mice

Human Health Effects of Lactose Consumption as a Food and Drug Ingredient

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