Gastric dysplasia may be an independent risk factor of anadvanced colorectal neoplasm

Abstract

AIM:To evaluate the relationship between gastric dysplasia and Helicobacter pylori (H pylori ) and the occurrence of colorectal adenoma, and to define the necessity for colonoscopy in patients with gastric dysplasia or H pylori infection. May 2005 to February 2008, 133 patients with established gastric dysplasia by gastroduo denoscopy (EGD) were additionally investigated by colonoscopy. The authors compared results with those of 213 subjects who underwent both EGD and colonoscopy during the same period at the author's Health Promotion Center as a control group. H pylori infection was evaluated in both the gastric dysplasia and control groups. METHODS: From RESULTS:The mean age of all 346 study subjects was 54.1 ± 10.5 years, and there were 258 (73%) men and 87 (27%) women. No significant difference was found between the H pylori positive and negative subjects in terms of the prevalence of colorectal adenoma and advanced colorectal adenoma (P = 0.261). Patients with gastric dysplasia showed no elevated risk of colorectal adenoma (OR = 0.910, 95% CI: 0.5871.411, P = 0.738), but had a significantly higher risk of having advanced colorectal adenoma (OR = 3.382, 95% CI: 1.7006.342, P = 0.000). CONCLUSION:The study emphasizes the need for colon surveillance in patients with gastric dysplasia, regardless of H pylori infection.

Association between Helicobacter pylori infection and the risk of colorectal neoplasia: a systematic review and meta‐analysis

“…One additional article was included from the reference review [25]. Finally, 27 articles published from December 1991 to June 2012 were used in the meta-analysis [3,4,[8][9][10]13,14,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. These studies included a total of 3792 cases of CRA and 3488 cases of CRC.…”

Association between Helicobacter pylori infection and colorectal neoplasm risk: A meta-analysis Based on East Asian population

“…[14] 2009 Korea 73 60 131 82 Serological Inoue et.al. [5] 2011 Japan 201 38 368 110 13 C UBT Hong et.al.…”

Frequency and risk factors of colorectal adenoma in patients with early gastric cancer

“…In patients with GC, CRC is one of the most common synchronous cancers. 9,10 Recently, pre-operative colonoscopy has been recommended for patients with gastric adenocarcinoma. [16][17][18] In addition, a recent retrospective study performed at a single healthcare centre suggested that adenomas of stomach and colorectum may be similar in terms of pathogenesis.…”

“…[6][7][8] Notably, colorectal cancer (CRC) is one of the most frequent synchronous cancers among patients with primary GC. 9,10 Thus, a synchronous colorectal neoplasm (CRN) should be screened for and eliminated, for example by colonoscopic examination, during pre-operative workup in selected high-risk patients. 11 Furthermore, it was suggested in recent studies, corrected for age and gender, that colonoscopy can be conducted before or after GC surgery because of the high-risk concurrent colon cancer.…”