Gastric Emptying and Intragastric Distribution of a Solid Meal in Functional Dyspepsia

Lorena, Sônia Letícia Silva; Tinóis, Eduardo; Brunetto, Sérgio Quirino; Camargo, Edwaldo E.; Mesquita, Márcio

doi:10.1097/00004836-200403000-00007

Cited by 65 publications

(57 citation statements)

References 31 publications

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“…Since psychological stresses have been shown to affect gastrointestinal motility, it seems that the emotional factors, such as depression and anxiety, have also a negative effect on gastric motility. However, there is some evidence which suggests that there is an association between psychological abnormalities and impaired gastric motor function in patients with functional Dyspepsia [47]. In the present study, families with five to six members had the highest frequency of developing dyspepsia (35.7%), while families with three members were least developed Dyspepsia (17.9%).…”

Section: Discussioncontrasting

confidence: 46%

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Ayele¹,

Molla²

2017

Clin Microbiol

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Dyspepsia is a common symptom of gastrointestinal disease with global distribution. The prevalence of this disorder varies between 3% and 40%. Dyspeptic symptoms account 10% of hospital admissions in Ethiopia. The aim of this study was to determine the contributing factors for dyspepsia at Yirga cheffe primary hospital, Southern Ethiopia.: A case control study design was conducted between July 6, 2016 and August 10, 2016 on a total of 168 patients at Yirga cheffe primary hospital, South Ethiopia. The Helicobacter pylori (H. pylori) stool antigen test was used to analyze the stool samples and a face to face interview was taken to assess other contributing factors for the infection. Ethical clearance and informed consents was obtained before data collection. Logistic regression analysis was used to estimate odds ratio (adjusted with 95% confidence interval) of positive responses to the different risk factors. Comparisons between groups were assessed with chi-square test and a P-value of <0.05 was considered statistically significant. Helicobacter pylori antigen was detected in 13 of the 168. Helicobacter pylori infection was six times more associated with dyspeptic patients than non-Dyspeptic individuals. Anxiety and depression was six and three times more likely associated with dyspepsia, respectively. Although dyspepsia was greater among male, and peaked in the age groups of 21-30 years old, the association was not statistically significant. Moreover, patients who consume foods containing peppercorn ("key wot") have high chance of developing Dyspepsia. Study subjects who depend on untapped drinking water sources, treating their drinking water, smoking habit, chewing khat, washing their hand with soap, and their toilet with flush tank were not significantly associated with dyspepsia (P>0.05). Thus, early diagnosis of H. pylori, psychological treatment of patients and food habit of the individuals should give attention to prevent and control Dyspepsia even though additional studies need to be conducted.

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Section: Discussioncontrasting

confidence: 46%

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Ayele¹,

Molla²

2017

Clin Microbiol

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“…Furthermore, psychosocial trait factors can negatively affect the clinical course 125 and shape treatment outcomes in functional dyspepsia 129,130 . Finally, different traits reportedly correlate with altered gastric sensorimotor functioning in functional dyspepsia, including gastric sensitivity, accommodation, antral meal retention and gastric emptying [131][132][133][134] .…”

Section: Psychosocial Factors and Brain Mechanismsmentioning

confidence: 98%

Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

260

247

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| Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation. A genetic predisposition is probable but less evident than in other functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). Psychiatric comorbidity and psychopathological state and trait characteristics could also play a part, although they are not specific to functional dyspepsia and are less pronounced than in IBS. Possible differential diagnoses include Helicobacter pylori infection and peptic ulceration. Pharmacological therapy is mostly based on the subtype of functional dyspepsia, such as prokinetic and fundus-relaxing drugs for PDS and acid-suppressive drugs for EPS, whereas centrally active neuromodulators and herbal drugs play a minor part. Psychotherapy is effective only in a small subset of patients, whereas quality of life can be severely affected in nearly all patients. Future therapies might include novel compounds that attempt to treat the underlying gastric and duodenal inflammation. NATURE REVIEWS | DISEASE PRIMERS VOLUME 3 | ARTICLE NUMBER 17081 | 1 PRIMER © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .standard therapy for gastro -oesophageal reflux disease. Paediatric dyspeptic symptoms are being addressed in a separate classification effort 10 . This Primer covers functional dyspepsia in adults only, although we sporadically refer to paediatric functional dyspepsia when similarities exist. EpidemiologyThe population prevalence of functional dyspepsia is quite variable across the globe, with overall high numbers (10-40%) in Western countries and low numbers (5-30%) in Asia, independent of the respective functional dyspepsia definitions 11 . A large-scale health and nutrition survey from France 12 (which involved >35,000 people) identified that 15% of individuals had suspected functional dyspepsia, 28% had irritable bowel syndrome (IBS) and 6% had both. The population of patients who are affected by both IBS and functional dyspepsia has been reported to range between 10% and 27% in previous studies 13 and to approach 30% in popu lation samples; it could be even higher in specific populations 14,15 . This observation has given rise to the term 'overlap syndrome' (REF. 13), which calls into question the sensitivity and specificity of the Rome criteria, at least for IBS and functional dyspepsia. This argument is also supported by the observation that patients with functional dyspepsia m...

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“…Electrical shock significantly decreased the percentage in the 3-cpm frequency group and tachyarrhythmia (%) component of the EGG, but forehead cooling increased the percentage of the 3-cpm frequency group (Muth et al, 1999). Anxiety has also been reported to facilitate antral meal retention (Lorena et al, 2004). The epigastric 3-and 6-cpm groups electrical activity in the EGG were suggested to reflect those of the colon on the basis of the EGG results obtained after total gastrectomy (Pezzola et al, 1989;Homma et al, 1995Homma et al, , 1999.…”

Section: Gastric Activitymentioning

confidence: 99%

Local differences in electrogastrographic responses to the stress of the mirror drawing test (MDT) as determined by multichannel electrogastrography

Homma

2012

J. Smooth Muscle Res.

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Electrogastrograms (EGGs) were recorded in human subjects (n=58) at 16 locations on the thoraco-abdominal surface before (at rest) and during the stress of the mirror drawing test (MDT) and after having a test meal. The power amplitude ratios and power content ratios of MDT to rest (MDT/rest) and postprandial state to rest (PPR/rest) were compared between gastric channels 5 and 8, and the infraumbilical channels 12, 13, 14, 15, and 16. Generally, the ratio of the 3-cpm group in channels 5 and 8 was lower than that of the infraumbilical channels 12-16 during MDT. In contrast, the ratios were higher in the epigastric channels than in the infraumbilical channels after a test meal. Significant differences between the epigstric and infraumbilical channels were found in the comparisons of the power content ratios. The infraumbilical channels were facilitated and the epigastric channels inhibited during MDT. After eating a meal, in contrast, the postprandial epigastric 3-cpm EGGs were facilitated. The epigastric 3-cpm EGG activity reflects gastric myoelectric activity, while the infraumbilical 3-cpm activity reflects that of the colon. Therefore, it is suggested that the acute stress of the MDT generally inhibited the gastric EGG and facilitated the colonic EGG, indicating gastric inhibition and colonic facilitation. The topographic EGG maps of the power content ratios and the absolute power ratios visually confirmed these findings.

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Gastric Emptying and Intragastric Distribution of a Solid Meal in Functional Dyspepsia

Cited by 65 publications

References 31 publications

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Functional dyspepsia

Local differences in electrogastrographic responses to the stress of the mirror drawing test (MDT) as determined by multichannel electrogastrography

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