Gastric Emptying in Atrophic Gastritis and Carcinoma of the Stomach

Davies, W.T.; Kirkpatrick, J. R.; Owen, G.; Shields, R.

doi:10.3109/00365527109181123

Cited by 46 publications

(13 citation statements)

References 11 publications

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“…The remaining fourteen results in Table 1 refer to meals of water, meals with volumes less than 330 ml., or meals whose emptying rates are not adequately described by our hypothesis, for reasons that are not apparent to us. An example is given in line 33 of Table 1 (Davies, Kirkpatrick, Owen & Shields, 1971). Results in an earlier paper by the same authors (Griffith et al 1968) (line 5) using 550 ml.…”

Section: The Datamentioning

confidence: 91%

The volume and energy content of meals as determinants of gastric emptying.

Hunt¹,

Stubbs²

1975

The Journal of Physiology

541

273

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SUMMARY1. Results were collected from thirty-three published and unpublished studies of gastric emptying. The volumes of the meals ranged from 50 to 1250 ml., and composition varied from pure carbohydrates to ordinary food.2. From the published composition of the meals, their nutritive density, as kcal/ml. (4.18 KJ/ml.) was computed: it ranged from zero to 2-3 kcal/ml.3. The volume of each meal, or test meal, delivered to the duodenum in 30 min was determined, assuming that gastric emptying was exponential.4. The greater the nutritive density of a meal, the less was the volume transferred to the duodenum in 30 min. The original volume of meal given was not a determinant of the rate of emptying (ml./min).5. The slowing of gastric emptying with a meal of high nutritive density was not sufficient to prevent an increased rate of delivery of energy to the duodenum (nutritive density x volume delivered in unit time) with a meal of high nutritive density.6. Assuming an appropriate relationship for the interaction of a stimulus (kcal/ml.) and duodenal receptors, it was possible to predict a rate of gastric emptying for each meal, given its nutritive density. Knowing the initial volume of the meal, it was possible to predict the mean half time for its emptying. 7. There were eight sets of anomalous results: in four the volumes of meal given were less than 200 ml.; explanations of the anomalies in the other four results could not be provided.8. The results are consistent with equal slowing of gastric emptying by the duodenal action of the products of digestion of isocaloric amounts of fat, protein and carbohydrate, for example, 4 g fat or 9 g carbohydrate, both 36 keal, taking carbohydrate and protein as 4 kcal/g and fat as 9 kcal/g.

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Section: The Datamentioning

confidence: 91%

The volume and energy content of meals as determinants of gastric emptying.

Hunt¹,

Stubbs²

1975

The Journal of Physiology

541

273

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“…The intraluminal administration of acid in normal subjects inhibits both gastric interdigestive motility [1] and gastric empty ing [2]. However, on one hand, patients with increased gastric acid secretion, as those with active duodenal ulcer, show an increased gas tric motility after a meal, which is emptied at a faster than normal rate [3][4][5]; on the other hand, the achlorhydria or hypochlorhydria observed in chronic atrophic gastritis is asso ciated with a decrease in gastroduodenal mo tor activity, both in the interdigestive period and after a meal [3,6,7],…”

mentioning

confidence: 99%

Interdigestive Gastroduodenal Motor Activity in Subjects with Increased Gastric Acid Secretion

Bortolotti¹,

Barbara²

1988

Digestion

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The interdigestive gastroduodenal motor activity was studied in 7 patients with active duodenal ulcer and increased gastric acid secretion, in 7 patients with hypersecretory gastroduodenitis and in 7 subjects with normal acid secretion, in whom the increase in acid secretion was obtained by means of the intravenous administration of an H₂ agonist, Impromidine. The gastroduodenal motor activity was recorded manometrically for about 200–300 min in basal conditions to obtain at least two subsequent activity fronts of the migrating motor complex (MMC cycle). Only in subjects with normal acid secretion was Impromidine administered at a dose of 2 μg/kg/h for 150 min followed by a dose of 10 μg/kg/h for another period of 150 min, to obtain, respectively, a submaximal and a maximal secretory response. Patients with spontaneous acid hypersecretion, with or without peptic ulcer, showed a longer than normal MMC cycle with a shorter than normal percent of time occupied by phase III. This motor activity was similar to that recorded in normal subjects during the increase in acid secretion induced by the lowest dose of Impromidine, whereas during the highest dose the gastroduodenal MMC was disrupted and replaced by an irregular motor activity.

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“…Impaired gastric evacuation is common after abdominal irradiation. Delayed solid emptying is noted in atrophic gastritis with or without pernicious anemia, possibly secondary to reduced gastric secretions that facilitate fragmentation of solid food residue [32]. The median arcuate ligament syndrome is caused by compression of the celiac axis by a fibrous band and presents with postprandial pain, nausea, vomiting and weight loss secondary to delayed gastric emptying [33].…”

Section: Other Causes Of Gastroparesismentioning

confidence: 99%

Management of gastroparesis

Hasler

2008

Expert Review of Gastroenterology & Hepatology

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Gastroparesis presents with nausea, vomiting, early satiety and abdominal discomfort, as well as a range of nongastrointestinal manifestations in association with delays in gastric emptying. The disorder may be a consequence of systemic illnesses, such as diabetes mellitus, occur as a complication of gastroesophageal surgery or develop in an idiopathic fashion and may mimic other disorders with normal gastric emptying. Some cases of idiopathic gastroparesis present after a viral infection. Management relies primarily on therapies that accelerate gastric emptying or reduce vomiting, although endoscopic or surgical options are available for refractory cases. Current research is focusing on the cellular and molecular mechanisms underlying development of delayed gastric emptying, as well as factors unrelated to motor dysfunction that may elicit some symptoms. Future pharmaceuticals will target the contractile and nonmotor defects via novel pathways. Novel electrical stimulation techniques will be employed either alone or in combination with medications.

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Gastric Emptying in Atrophic Gastritis and Carcinoma of the Stomach

Cited by 46 publications

References 11 publications

The volume and energy content of meals as determinants of gastric emptying.

The volume and energy content of meals as determinants of gastric emptying.

Interdigestive Gastroduodenal Motor Activity in Subjects with Increased Gastric Acid Secretion

Management of gastroparesis

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