Gastric Emptying in Migraine: A Comparison With Functional Dyspepsia

Abstract

Background/AimsGastric stasis in migraineurs remains controversial. The aim of this study is to investigate gastric emptying (GE) time, and any associations between GE parameters and dyspeptic symptoms among patients with functional dyspepsia (FD) and migraine without any gastrointestinal symptoms during the interictal period.MethodsWe enrolled 27 migraine patients, 32 FD patients and 12 healthy people as controls, and performed GE scintigraphy as gastric function test. Gastrointestinal symptoms were evaluated in the FD and migraine.ResultsThe age-adjusted mean gastric half-emptying time in FD (125.51 ± 52.55 minutes) patients was longer than in migraineurs (100.82 ± 23.94 minutes, P = 0.035) and controls (95.25 ± 23.29 minutes, P = 0.021). The percentage of gastric retention was higher in FD than in migraine. However, migraineurs did not show an obvious delayed gastric emptying or an increase of gastric retention when compared to the normal controls. The association between each dyspeptic symptom and GE parameters was not significant, but postprandial fullness and early satiety showed a tendency of delayed GE. In migraineurs, GE time did not show significant association with nausea and vomiting during interictal periods.ConclusionsDelayed GE does not appear to be a mechanism that patients with FD and migraine have in common. Migraineurs without dyspepsia during interictal period had normal GE, and further study for association with FD should be investigated.

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

“…Out of 53 patients who followed up, 24 patients (nearly 45%) gave a feedback of complete recovery, with emphasis of introducing simple lifestyle modifications in their day to day life. This in a way is proving that assumptions made in the study holds good with the data ( 21,29,37,44) .…”

“…While 24% (84) patients did not recover with only modifications of lifestyle, as they required oral medications also to show response to treatment. Once again, this tabulation in a way proves the aim that was taken up during the course of the study ( 13,29) .…”

Effect of Flavonoid Rich Root Extract Of Glycyrrhizaglabra on Gastric Emptying and Gastrointestinal Transit in Albino Wistar Rats

“…The health related quality of life is impacted significantly in patients with FD when compared to general healthy population [6,7]. A disturbance in gastric emptying has been reported to be a major pathophysiological mechanism of FD [1].…”

“…Gastric emptying (GE) is the process of transferring the gastric content to the small intestine as the result of motor activity of the stomach, pylorus and duodenum under the control of inhibitory and stimulatory mechanism [8,1]. Drugs that enhance GE are effective in the treatment of FD [2].…”

“…Delayed gastric emptying is considered as a major pathophysiologic mechanism in FD, and it has been identified in 29% -59% of patients with FD [1]. Although several agents have been evaluated for FD, drugs approved by FDA are not available for treatment of FD.…”