Gastric Emptying of Pellets under Fasting Conditions: A Mathematical Model

Abstract

Mean gastric emptying of pellets was adequately described by the Weibull model (eta = 61.9 min, beta = 0.895), which could be applied in the design of in vitro dissolution experiments for pellet formulations with pH dependent dissolution.

Does age affect gastric emptying time? A model‐based meta‐analysis of data from premature neonates through to adults

“…Based on visual inspection of the % remaining versus time data, three structural models were tested: namely exponential decay 34, exponential decay with a lag time 34 and a double Weibull function 35. An advantage of the latter model (Eq.…”

Prediction of in-vivo pharmacokinetic profile for immediate and modified release oral dosage forms of furosemide using an in-vitro–in-silico–in-vivo approach

“…Locatelli et al . reported that the gastric emptying rate of pellets in the fasted state can be described by a Weibull function, equation (5), based on in‐vivo scintigraphic profiles [28]. The overall mean gastric emptying was estimated by fitting the mean in‐vivo scintigraphic profiles ( n = 28) to the Weibull function.…”

“…Because the gastric residence time was longer using the Weibull function than using the standard first‐order emptying constant, a total of 5 h for the passage through the upper GI tract was applied for the MR capsules in the model. where PE ( t ) is the % of pellets remaining in the stomach at a given time t (min), as described by Locatelli et al. 's Weibull fit to pellet emptying data [28]…”

“…The same parameters as IR tablets were evaluated (Table ). To investigate the influence of the gastric emptying rate, the following variations to the Weibull function for gastric emptying were used to cover the range of gastric emptying reported in the literature [28]. The mean in‐vivo scintigraphic profiles from a fast‐emptying population ( n = 12) and from a slow‐emptying population ( n = 7) were fitted to the Weibull function.…”

Analysis of factors influencing gastric emptying of pellets in a fed state

“…One of the most rate-limiting steps in the GI transit of oral dosage forms is gastric emptying (GE). The gastric residence time of a non-disintegrating, solid drug delivery system (DDS) depends on physiological factors such as the fasting or fed state of the stomach, and on the dosage form characteristics, particularly its density and size [4][5][6]. Because the residence time of a DDS in a gastric medium may affect drug release and absorption processes, the GE process has become a topic of great interest in the context of the development and optimization of a novel DDS.…”