Gastric erosions induced by analgesic drug mixtures in the rat

Seegers, A. J. M.; Jager, L. P.; Noordwijk, J. van

doi:10.1111/j.2042-7158.1978.tb13167.x

Cited by 28 publications

(3 citation statements)

References 20 publications

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“…A synergistic action of caffeine and aspirin-like drugs seriously increases the risk of gastric erosions (18). The increase in gastric complaints during tolfenamic acid-caffeine treatment was not statistically significant.…”

Section: Discussionmentioning

confidence: 85%

Tolfenamic Acid and Caffeine: A Useful Combination in Migraine

Hakkarainen

Parantainen²,

Gothóni³

et al. 1982

Cephalalgia

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Tolfenamic acid is a potent inhibitor of prostaglandin biosynthesis, which has been proved effective in the treatment of acute migraine attacks. The usefulness of caffeine, metoclopramide and pyridoxine as adjuncts to tolfenamic acid was tested in acute migraine attacks in ten patients. A combination of tolfenamic acid (200 mg) with either caffeine (100 mg), metoclopramide (10 mg) or pyridoxine (300 mg) was given twice to each patient in random order. Thus 60 attacks were treated. The tolfenamic acid-caffeine combination proved the most effective as judged by duration and intensity of attacks, working ability, vigilance, and overall evaluation of the drugs by the patients. Metoclopramide was somewhat better than pyridoxine as an additive.

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Section: Discussionmentioning

confidence: 85%

Tolfenamic Acid and Caffeine: A Useful Combination in Migraine

Hakkarainen

Parantainen²,

Gothóni³

et al. 1982

Cephalalgia

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“…'( II Animal as well as human studies have also recently suggested that treatment with acetaminophen may exert a protective effect against the mucosal damage commonly seen with aspirin and alcohol. 1( 12 13 Logic would suggest, therefore, that a safer regimen in which NSAIDs are recommendedthat is, in which mucosal damage is to be avoided, would be a combination of ibuprofen, one of the least damaging of the NSAIDs and acetaminophen for its protective effect. This study was designed to determine whether or not acetaminophen, given concurrently with ibuprofen, produced a protective effect against the mucosal injury seen with ibuprofen.…”

mentioning

confidence: 99%

Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen.

Lanza¹,

Royer²,

Nelson³

et al. 1986

Gut

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SUMMARY Acetaminophen has been proposed as an agent which protects the gastric mucosa against damage induced by aspirin and other non-steroidal anti-inflammatory agents. In order to evaluate this proposal further, 45 normal human volunteers were divided into three groups (n= 15); group one received ibuprofen 2400 mg daily (600 mg qid); group two received acetaminophen 3900 mg daily (975 mg qid) and group three received both drugs at the same dosages. There was no significant difference in the mucosal injury scores noted at endoscopy between the ibuprofen and the ibuprofen-acetaminophen group. The acetaminophen group had virtually no observed mucosal injury and this was statistically significant in comparison with the other groups (p<0-01). We conclude that contrary to previously reported studies using single doses of aspirin, acetaminophen failed to decrease the mucosal injury seen with ibuprofen when given for a period of seven days in combination with acetaminophen.

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“…Although it has been reported that paracetamol can prevent the formation of gastric mucosal lesions induced by ethanol or acidified aspirin in animals and man (Seegers et al 1978;Konturek et al 1982;Stern et al 1984;Poon et a1 1987). Graham & Smith (1985) and Nakagawa & Okabe (1987) failed to show that paracetamol has cytoprotective activity against aspirin, ibuprofen and ethanol-evoked mucosal lesions.…”

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confidence: 97%

Paracetamol potentiates stress-induced gastric ulceration in rats

Cho

Ogle

1990

Journal of Pharmacy and Pharmacology

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The effect of paracetamol on gastric ulcers produced by restraint at 4 degrees C for 2 h (stress) was studied in rats. Paracetamol treatment s.c. or p.o., with a dose as high as 250 mg kg-1, did not produce any haemorrhagic lesions in the glandular mucosa. Oral administration with 250 mg kg-1, however, significantly reduced the mast cell count in the gastric glandular mucosa and potentiated haemorrhagic ulceration but not mast cell degranulation caused by stress. The potentiating action was maximum when paracetamol was given between 15 and 30 min before stress. Ranitidine, astemizole, dimethylsulphoxide, sucralfate and verapamil did not protect against the adverse action of paracetamol on stress-evoked lesions. This study suggests that paracetamol worsens stress-induced stomach ulceration by an action which appears not to be due to histamine release, free radical production or intracellular calcium disturbance in the gastric mucosa.

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Gastric erosions induced by analgesic drug mixtures in the rat

Cited by 28 publications

References 20 publications

Tolfenamic Acid and Caffeine: A Useful Combination in Migraine

Tolfenamic Acid and Caffeine: A Useful Combination in Migraine

Effect of acetaminophen on human gastric mucosal injury caused by ibuprofen.

Paracetamol potentiates stress-induced gastric ulceration in rats

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