Gastric hyperplastic polyp with focal cancer

Markowski, Adam R.; Guzińska‐Ustymowicz, Katarzyna

doi:10.1093/gastro/gou077

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…It was not long ago that GHPs were believed to be benign lesions not associated with the risk of malignant transformation. Today, however, unremoved GHPs are known for their ability to enlarge and sometimes spontaneously undergo a sequential progression and a few-phase neoplastic transformation[12]. This process has been confirmed and well documented in GHPs, although it is much less common than in adenomatous polyps of the stomach.…”

Section: Pathophysiologymentioning

confidence: 99%

Pathophysiological and clinical aspects of gastric hyperplastic polyps

Markowski¹,

Markowska²,

Guzińska‐Ustymowicz³

2016

WJG

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Gastric polyps become a major clinical problem because of high prevalence and tendency to malignant transformation of some of them. The development of gastric hyperplastic polyps results from excessive proliferation of foveolar cells accompanied by their increased exfoliation, and they are macroscopically indistinguishable from other polyps with lower or higher malignant potential. Panendoscopy allows detection and differentiation of gastric polyps, usually after obtaining histopathological biopsy specimens. Unremoved gastric hyperplastic polyps may enlarge and sometimes spontaneously undergo a sequential progression to cancer. For this reason, gastric hyperplastic polyps larger than 5 mm in size should be removed in one piece. After excision of polyps with atypical focal lesion, endoscopic surveillance is suggested depending on histopathological diagnosis and possibility of confirming the completeness of endoscopic resection. Because of the risk of cancer development also in gastric mucosa outside the polyp, neighboring fragments of gastric mucosa should undergo microscopic investigations. This procedure allows for identification of patients who can benefit most from oncological endoscopic surveillance. If Helicobacter pylori (H. pylori) infection of the gastric mucosa is confirmed, treatment strategies should include eradication of bacteria, which may prevent progression of intestinal metaplasia. The efficacy of H. pylori eradication should be checked 3-6 mo later.

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Section: Pathophysiologymentioning

confidence: 99%

Pathophysiological and clinical aspects of gastric hyperplastic polyps

Markowski¹,

Markowska²,

Guzińska‐Ustymowicz³

2016

WJG

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“…The incidence of malignant changes is relatively low, appearing mainly in those that measure more than 1 cm, being found focal intestinal metaplasia, dysplasia, and adenocarcinoma in 5-37%, 2-20%, and 2-6% of cases, respectively [ 12 – 14 ]. Carcinomas related to HP are usually well differentiated, although some cases of poorly differentiated carcinomas have been reported [ 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is suggested to resect HP if they are symptomatic, if they present atypical characteristics, or if they are greater than 1 cm, since they have a greater potential for malignant transformation [ 13 ]. When HPs measure less than 1 cm, biopsy and follow-up should be performed [ 12 , 15 ]. It is also important to perform biopsies of the surrounding mucosa, to rule out the presence of gastritis associated with H .…”

Section: Discussionmentioning

confidence: 99%

Focal Intramucosal Adenocarcinoma Occurring in Gastric Hyperplastic Polyps Treated with Endoscopic Mucosal Resection

Alférez-Andía¹,

Benites-Goñi

Palacios-Salas

2018

Case Reports in Gastrointestinal Medicine

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Hyperplastic polyps are the most frequent benign epithelial gastric polyps. Although they are considered nonneoplastic, some cases have been reported with focal adenocarcinoma. We present the case of a 59-year-old woman with a sessile lesion of 15 mm on the distal gastric body associated with an extensive atrophic gastritis. Magnifying endoscopy with Fuji Intelligent Color Enhancement (FICE) revealed an irregular microsurface pattern at the apex, suggesting malignancy. A mucosectomy was performed. The histopathology revealed that the base corresponded to a hyperplastic polyp, where a tubular adenoma with high-grade dysplasia was established, with focal well-differentiated intramucosal tubular adenocarcinoma.

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“…1,2 Th e gastric polyps which are rarely symptomatic may present with bleeding, iron defi ciency anemia, abdominal pain and gastric pyloric obstruction when they reach large sizes. [2][3][4][5] Th e World Health Organization has classifi ed gastric polyps in 3 groups. Th ese are non-neoplastic polyps, neoplastic polyps and reactive polypoid lesions.…”

Section: Introductionmentioning

confidence: 99%

Mi̇de Poli̇pleri̇; 264 Üst Gastroi̇ntesti̇nal Si̇stem Endoskopi̇si̇ni̇n Retrospekti̇f Anali̇zi̇

Durgut¹,

Yavuz²

2022

Sakarya Medical Journal

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Objective: The main objective of our study was to evaluate the data of our patients who underwent polypectomy with the diagnosis of gastric polyp in our endoscopy clinic by comparing type, size, number and histopathological evaluation results of the polyps with the literature data. Methodology: In our study, the histopathological and demographic data of 264 cases who were detected among 9654 upper gastrointestinal endoscopies and underwent polypectomy performed in XX and XX Hospitals in between the years 2014-2019 were retrospectively analyzed. Findings: Among our patients 140 were male and 124 were female. The mean age was 55.8 in females and 54.4 in males. The results were reported as hyperplastic polyp in 185 cases (70.1%), fundic gland polyps in 15 cases (5.7%), adenomatous polyps in 8 cases (3.0%), inflammatory polyps in 16 cases (6.1%), foveolar hyperplasia in 18 cases (6.8%), lymphoid hyperplasia in 19 cases (7.2%), carcinoid tumor in 1 case (0.4%), adenocalcinoma in 1 case (0.4%) and leiomyoma in 1 case (0.4%). According to their location, 142 (53.8%) were in the antrum, 73 (27.7%) were in the corpus, 28 (10.6%) were in the fundus, 20 (7.6%) were in the cardia, and 1 (0.4%) were in the pylorus. No precancerous lesions were detected in 75.4% of our patients. Metaplasia in 53 (20.1%) cases, atrophy in 6 (2.3%) cases, low-grade dysplasia in 5 (1.9%) cases, and high-grade dysplasia in 1 case were detected. Conclusion: Stomach polyps are usually incidentally detected polyps which are most commonly seen in the antrum and carpus. Hyperplastic polyps are the most common type of polyp and their relationship with helicobacter pylori has been proven. The results of our study were correspondingly similar to the findings in literature.

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Gastric hyperplastic polyp with focal cancer

Cited by 11 publications

References 13 publications

Pathophysiological and clinical aspects of gastric hyperplastic polyps

Pathophysiological and clinical aspects of gastric hyperplastic polyps

Focal Intramucosal Adenocarcinoma Occurring in Gastric Hyperplastic Polyps Treated with Endoscopic Mucosal Resection

Mi̇de Poli̇pleri̇; 264 Üst Gastroi̇ntesti̇nal Si̇stem Endoskopi̇si̇ni̇n Retrospekti̇f Anali̇zi̇

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