Gastric inflammatory myofibroblastic tumor presenting as fever of unknown origin in a 9-year-old girl

Jumanne, Shakilu; Shoo, Aika; Mumburi, Livin; Akoko, Larry; Scanlan, Patricia; McDermott, Michael W.

doi:10.1097/meg.0000000000000742

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histopathological evaluation of a biopsy or the surgical specimen with IHC is a must to establish the diagnosis of this rare tumor. Based on clinicopathological and imaging features without IHC, it can easily be confused with gastrointestinal stromal tumor (GIST), immunoglobulin subtype G4 (IgG4)-related disease as well as liposarcoma, follicular dendritic cell sarcoma, solitary or calcifying fibrous tumor, and metastatic or spindle cell sarcoma or sarcomatoid carcinoma [ 10 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is negative for CD34 and S-100 as well. The IMTs usually stain positive for one or more of SMA, vimentin, desmin, and ALK in 50-60% of cases, and this entire IHC study is necessary to make a diagnosis as summarized in Table 1 [ 6 , 7 , 10 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Occasional reports of spontaneous regression, chemotherapy, high-dose steroid therapy, non-steroidal anti-inflammatory drug therapy, and radiation have been published, but these tumors seem to be IPTs and not IMTs. Local recurrence rates are up to 25%, and large tumor size at presentation, abdominopelvic location, and older age are the risk factors [ 2 , 6 , 7 , 12 , 15 ]. On the other hand, metastasis has been reported in less than 5% of cases, and younger age and lack of ALK expression are the risk factors [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Giant Solid-Cystic Gastric Inflammatory Myofibroblastic Tumor: A Case Report and Literature Review

Desai¹,

Parikh²,

Wagle³

2023

Cureus

View full text Add to dashboard Cite

An inflammatory myofibroblastic tumor (IMT) is a very rare tumor of mesenchymal origin with unclear etiopathogenesis, no unique diagnostic features, and no specific management protocol. It is often confused with inflammatory pseudotumor in literature, and the distinction needs further study. The average size, recurrence risk, and metastatic potential differ as per the site of origin. The abdomen is a very rare site for IMTs. Hepatic IMTs (H-IMTs) are reported to be solid tumors with sizes ranging from 1 cm to 20 cm in literature, and gastric IMTs (G-IMTs) range from 3 cm to 10 cm in size and can be solid-cystic. We report here a case of a 36-year-old gentleman with a 34x27x17 cm solid-cystic lesion in the lesser sac with loss of fat planes with stomach and left hemi-liver. The patient was managed by complete surgical resection of the lesion with wedge gastrectomy and wedge hepatectomy and recovered uneventfully. To our knowledge and based on our literature review, this case presents the largest reported and solid-cystic G-IMT with the involvement of left hemi-liver in a young gentleman and discusses its management as well as the relevant literature on this rare entity. This clinical presentation of G-IMT should be kept in the differential diagnosis in a relevant case presenting in the future. Immunohistochemistry is a must to establish the diagnosis, and surgical resection to negative margins is the management option of choice in resectable cases.

show abstract

Section: Discussionmentioning

confidence: 99%