Gastric metastases mimicking primary gastric cancer: A brief literature review

Gurzu, Simona; Beleaua, Marius Alexandru; Banias, Laura; Jung, Ioan

doi:10.4103/ctm.ctm_67_16

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…The suspicion of a metastasis from a lobular carcinoma of the breast is eliminated based on negativity for specific markers such mammaglobin, ER, PR, and GATA 3 [1, 3, 11, 12]. However, the poorly cohesive gastric carcinomas can express ER [1, 11, 12] and urothelial carcinoma can be diffusely positive for GCDFP-15 [1] and express nuclear GATA3 [1, 3]. CD138 can mark the breast lobular carcinoma but its expression is simultaneously seen in tumor and stroma cells [13].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity

Kovács

Gurzu

Molnar

et al. 2019

Journal of Oncology

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Background. Plasmacytoid urothelial carcinoma is a rare and aggressive histologic variant of high-grade carcinoma of the urinary bladder. Few than 250 cases have been reported in the urinary bladder till January 2019. In this paper, a case series of unusual gastrointestinal carcinomas with plasmacytoid morphology was included. Only one similar case of the stomach was previously published and no such cases were found in colon. Methods. We present the complex immunoprofile, using a panel of 39 biomarkers, of the largest group of primary gastrointestinal carcinomas with plasmacytoid morphology reported in literature (one from upper rectum and six from stomach). Results. All of the seven cases showed lymph node metastases and only one survived over 25 weeks after surgical excision. The indicators of aggressivity were age (over 60), advanced stage (from IIIA to IV), E-cadherin negativity, and vimentin positivity. The immunoprofile indicated unfavorable prognosis for mesenchymal-type carcinomas (negativity for E-cadherin and positivity for vimentin, with membrane to nuclear translocation or negativity of β-catenin). The survivor showed an “epithelial-type adenocarcinoma with plasmacytoid dedifferentiation”, with membrane positivity for E-cadherin and β-catenin and vimentin negativity. All of the cases expressed c-MET and were negative for HER-2. Conclusions. Primary carcinoma with plasmacytoid morphology is a dedifferentiated variant of adenocarcinoma or poorly cohesive carcinomas. Vimentin positive dedifferentiated-poorly cohesive carcinomas should be considered as mesenchymal-type highly malignant carcinomas. This rare histologic variant of gastrointestinal cancer might respond to anti-c-MET tyrosine kinases.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity

Kovács

Gurzu

Molnar

et al. 2019

Journal of Oncology

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“…Patients present with a landscape of nonspecific symptoms such as anorexia, dysphagia, early satiety, postprandial bloating, epigastric pain, melena, nausea, and vomiting [ 12 , 24 , 29 ]. Aside from symptoms being nonspecific, they also mimic the side effects of chemotherapy or other medication, liver metastasis, and even hypercalcemia of malignancy [ 2 ].…”

Section: Reviewmentioning

confidence: 99%

“…This can further cause a delay in diagnosis or misdiagnosis of the disease. Clinically and endoscopically, it is almost impossible to differentiate primary GI tumors or non-Hodgkin lymphoma from metastatic disease [ 12 , 29 ].…”

Section: Reviewmentioning

confidence: 99%

An Uncommon Presentation of a Common Disease: A Review of Gastric Metastasis From Breast Carcinoma

Geada

Kantor

Mohan

et al. 2020

Cureus

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“Homomorphic” Tumor Metastases as an Endodiagnostic Clue: A Case Series of Renal-Cell Carcinoma Metastatic to the Stomach

Weissman

Mehta

Zhornitskiy

et al. 2019

Gastrointest Tumors

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Distinguishing between a primary malignancy and a metastasis can be challenging in some cases. Herein, we describe 2 cases of gastric lesions that were endoscopically sampled and ultimately found to be metastatic from a renal-cell carcinoma. In both cases, the gastric metastases were endoscopically homomorphic to the primary organ (the kidney); i.e., grossly resembling and thus providing an endoscopic clue as to the primary tumor source. We report on the evaluation of obscure metastatic gastric involvement of malignancy and present the concept of homomorphism as a potential diagnostic clue in determining the source of unknown and often unsuspected primary malignancy.

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Gastric metastases mimicking primary gastric cancer: A brief literature review

Cited by 3 publications

References 2 publications

Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity

Gastrointestinal Carcinoma with Plasmacytoid Morphology: Positivity for c-MET, Arylsulfatase, and Markers of Epithelial-Mesenchymal Transition, as Indicators of Aggressivity

An Uncommon Presentation of a Common Disease: A Review of Gastric Metastasis From Breast Carcinoma

“Homomorphic” Tumor Metastases as an Endodiagnostic Clue: A Case Series of Renal-Cell Carcinoma Metastatic to the Stomach

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