Gastric Metastasis of Ectopic Breast Cancer Mimicking Axillary Metastasis of Primary Gastric Cancer

Kayilioglu, Selami Ilgaz; Akyol, Cihangir; Esen, Ebru; Cansiz-Ersoz, Cevriye; Kocaay, Akın Fırat; Genç, Volkan; Kepenekçi, İlknur; Demirer, Seher

doi:10.1155/2014/232165

Cited by 8 publications

(12 citation statements)

References 15 publications

(17 reference statements)

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“…Thus, it is suggested to perform deep and extensive biopsies and to repeat them if negative, for obtaining representative material (41,42).…”

Section: Pathologic Diagnosticmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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patologic corect, imunohistochimia ne oferă un diagnostic de certitudine. Introducerea unui protocol de supraveghere endoscopică pentru pacienţii cu cancer lobular de sân ar putea fi o propunere pentru detectarea precoce a metastazelor gastrice care să permită o terapie adecvată.Cuvinte cheie: metastaze gastrice, cancer de sân lobular, teste imunohistochimice, endoscopie superioară Abstract Introduction: The predilection of lobular invasive breast cancer metastasis for the stomach is a topic that has succumbed to various assumptions over the time. Background and Aims: Gastric metastasis of lobular breast cancer is unusual and it can be diagnosed after a long period of time from primary tumor diagnosis. The aim of this study was to review current knowledge regarding the current methods of diagnosis and treatment of gastric metastasis of breast cancer. Methods: A systematic literature search was performed in the Pub-Med -Medline database using the terms "gastric metastasis of lobular breast cancer" and "gastric metastasis features" to identify articles relevant to gastric metastasis of lobular breast cancer. Results: Several papers have shown that the topic is rarely presented in the form of case presentations or miniseries by summing up sporadic cases. Due to its rarity and metastasis specificity as host type and appearance after latency of lobular breast cancer makes its gastric metastasis considered atypical and occasionally confused with a primary stomach malignancy. The most recent articles present the immunohistochemical diagnostic criteria of this clinical entity and a new therapeutic approach. Conclusion: At patients with gastric metastasis of lobular breast cancer, obtaining pathologic material and biopsies interpretation can be a real challenge for getting a correct pathologic diagnosis, immunohistochemistry gives us definite diagnosis. The introduction of an endoscopic surveillance protocol for patients with lobular breast cancer could be a proposal for the detection of early gastric metastases allowing for appropriate therapy.

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“…Thus, it is suggested to perform deep and extensive biopsies and to repeat them if negative, for obtaining representative material (41,42).…”

Section: Pathologic Diagnosticmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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“… 10 In most previous studies performed regarding the topic, ER and PR were positive. 6-11 However, these markers are not useful for diagnosing breast cancer metastases to the gastrointestinal area and stomach when the primary lesion is negative for ER and PR. 12 In our case, because the primary breast cancer was detected as triple-negative, pathologists had difficulty diagnosing the specimen obtained from the stomach.…”

Section: Discussionmentioning

confidence: 99%

“…While approximately 30% of gastric adenocarcinomas are CK7+/CK20+, 20% are CK7 - /CK20 + , 10% are CK7 - /CK20 - , and 20% are CK7 + /CK20 - . 6-15 The immunoperoxidase technique shows GCDFP-15 is negatively found in malignant lesions of the gastric area. 13 Chia et al used GCDFP-15 to diagnose in ER negative tumors, and in recurrent or metastatic breast cancer cases, mammaglobin was superior to GCDFP-15 in diagnosing metastases that originate from breasts (mammaglobin positive in 47.8% of cases vs. GCDFP-15 positive in 11.3%).…”

Section: Discussionmentioning

confidence: 99%

Gastric Metastasis of Triple Negative Invasive Lobular Carcinoma

Geredeli¹,

Doğru

Ömeroğlu

et al. 2015

Rare Tumors

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Invasive lobular carcinomas are the second most common type (5% to 15%) of invasive breast carcinomas. The most frequent sites of breast cancer metastasis are the local and distant lymph nodes, brain, lung, liver, and bones; metastasis to the gastrointestinal system, especially to the stomach, is rare. When a mass is detected in an unusual place in a patient with invasive lobular carcinoma, it should be kept in mind that such a mass may be either a second primary carcinoma or the metastasis of an invasive lobular carcinoma. In this report, we present a case of gastric metastasis from triple-negative invasive lobular breast cancer. It is important to make an accurate diagnosis by distinguishing gastric metastasis from breast cancer in order to select the best initial treatment for systemic diseases of breast cancer. Considering our case, healthcare professionals should take into account that cases with invasive lobular breast cancer may experience unusual metastases.

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“…Gastric metastases are usually localized in submucosal and seromuscolar layers; in more than 50% of cases endoscopy study is negative [70] . In one case report [18] first histological examination of gastric biopsies was negative; after synchronous diagnosis of primary breast cancer, endoscopy was repeated and biopsies of submucosal layer were performed again, showing gastric metastasis from lobular cancer. Also in another patient [19] initial gastric biopsies were negative, reporting only mild chronic gastritis.…”

Section: Diagnosis (Instrumental)mentioning

confidence: 99%

Breast cancer metastasis to the stomach

D’Angelo¹,

Rampini²,

Cardella³

et al. 2019

JCMT

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Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer. Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from 2000 to 2018 and case reports from 2013 to 2018. We found 11 reviews and 36 case reports and we compared their findings about important aspects of gastric metastasis, such as disease free survival, overall survival, symptoms, endoscopic findings, therapy, histology, and immunohistochemistry. Results: The incidence of stomach as site of metastasis of breast cancer ranges from 5% to 18%. Reviews and case reports reached similar conclusions about several of the aforementioned aspects: invasive lobular breast cancer (ILC) is mainly responsible for gastric metastases; disease free survival can vary greatly ranging from 0.5 months to 30 years; gastric metastases usually present with non-specific symptoms, even though five patients in case reports were asymptomatic; linitis plastica is the most common endoscopic finding; immunohistochemistry is essential for differentiating primary gastric cancer from metastasis; the preferred treatment is systemic therapy, but surgery is still an option in case of emergency; median overall survival of patients with gastric metastasis from breast cancer is 24 months. Conclusion: Breast metastasis to the stomach should be considered in any patient suspecting gastric neoplasm previously treated for breast carcinoma, especially if the treated carcinoma was ILC.

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Gastric Metastasis of Ectopic Breast Cancer Mimicking Axillary Metastasis of Primary Gastric Cancer

Cited by 8 publications

References 15 publications

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Gastric Metastasis of Triple Negative Invasive Lobular Carcinoma

Breast cancer metastasis to the stomach

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