Gastric Metastasis of Triple Negative Invasive Lobular Carcinoma

Geredeli, Çağlayan; Doğru, Osman; Ömeroğlu, Ethem; Yilmaz, Farise; Çiçekci, Faruk

doi:10.4081/rt.2015.5764

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…Each case is clinically unique, as outlined in the aforementioned discussion. Although there are reported cases of triple negative lobular cancers in the literature, those cases are usually in the pleomorphic form [8,21,22] . All of our cases were negative for HER-2.…”

Section: Resultsmentioning

confidence: 99%

Breast cancer metastases to the stomach and colon mimicking primary gastrointestinal cancer: Four cases and literature review

Üskent

Baloğlu²,

Çakmakçı³

et al. 2016

Adv Mod Oncol Res

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Abstract:Intraluminal gastric and colonic metastases of the breast cancer are very rare and may sometimes prove a diagnostic dilemma to distinguish from primary gastric and colonic cancers. It is important to make the distinction in order to navigate the proper treatment approach, which is a systemic treatment rather than surgery if the disease is metastatic. The spread to the gastrointestinal (GI) tract is more frequent in lobular histology and according to a number of investigators, it is related to a particular tropism of lobular cells toward gastrointestinal mucosa. Any region of GI tract may be involved, from the tongue to the anus. Over the last decade, among the 1,100 breast cancer cases registered at our institutions, we diagnosed four patients with breast cancer who had metastases to the stomach and/or colon and presented symptoms that simulated primary gastrointestinal cancer. A total of 84 out of the 1,100 patients experienced invasive lobular histology. Among the four patients with GI tract metastases, three were diagnosed with lobular histology -two of whom had the signet ring cell subtype. The remaining patient was diagnosed with triple negative invasive ductal carcinoma; however, it clinically resembled invasive lobular carcinoma. Clinical and pathological features of these cases, as well as the review of related literature are discussed in this report.

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Section: Resultsmentioning

confidence: 99%

Breast cancer metastases to the stomach and colon mimicking primary gastrointestinal cancer: Four cases and literature review

Üskent

Baloğlu²,

Çakmakçı³

et al. 2016

Adv Mod Oncol Res

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“…The invasive lobular cancer that represents 5%-10% of primary breast cancers, frequently involves unusual metastatic sites such as the gastrointestinal tract, the gynaecological organs, the peritoneum and meninges (10)(11)(12)(13)(14) in contrast to the invasive ductal cancer that follows the more conventional metastatic pattern of breast cancers and metastasizes in liver, lungs and brain (15,16).…”

Section: Epidemiologymentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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patologic corect, imunohistochimia ne oferă un diagnostic de certitudine. Introducerea unui protocol de supraveghere endoscopică pentru pacienţii cu cancer lobular de sân ar putea fi o propunere pentru detectarea precoce a metastazelor gastrice care să permită o terapie adecvată.Cuvinte cheie: metastaze gastrice, cancer de sân lobular, teste imunohistochimice, endoscopie superioară Abstract Introduction: The predilection of lobular invasive breast cancer metastasis for the stomach is a topic that has succumbed to various assumptions over the time. Background and Aims: Gastric metastasis of lobular breast cancer is unusual and it can be diagnosed after a long period of time from primary tumor diagnosis. The aim of this study was to review current knowledge regarding the current methods of diagnosis and treatment of gastric metastasis of breast cancer. Methods: A systematic literature search was performed in the Pub-Med -Medline database using the terms "gastric metastasis of lobular breast cancer" and "gastric metastasis features" to identify articles relevant to gastric metastasis of lobular breast cancer. Results: Several papers have shown that the topic is rarely presented in the form of case presentations or miniseries by summing up sporadic cases. Due to its rarity and metastasis specificity as host type and appearance after latency of lobular breast cancer makes its gastric metastasis considered atypical and occasionally confused with a primary stomach malignancy. The most recent articles present the immunohistochemical diagnostic criteria of this clinical entity and a new therapeutic approach. Conclusion: At patients with gastric metastasis of lobular breast cancer, obtaining pathologic material and biopsies interpretation can be a real challenge for getting a correct pathologic diagnosis, immunohistochemistry gives us definite diagnosis. The introduction of an endoscopic surveillance protocol for patients with lobular breast cancer could be a proposal for the detection of early gastric metastases allowing for appropriate therapy.

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“…It has been documented that the invasion and metastasis of tumor cells is a major cause of mortality in patients with cancer (5). Clinical evidence has also indicated that the prognosis of gastric cancer is associated with the stage of disease at diagnosis, with early diagnosis of gastric cancer resulting in a lower incidence of metastasis and a five-year survival rate of >90% (6). Although a number of studies have focused on gastric cancer at the molecular level (7)(8)(9), the mechanism underlying the invasion and metastasis of gastric cancer remains unknown.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11

Yang

Mei

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to evaluate the expression of microRNA (miR)-421 in gastric cancer and to investigate its biological function and underlying mechanism of action in the development of gastric cancer. The expression of miR-421 was measured in 60 pairs of clinically removed gastric cancer tissues and matched adjacent normal gastric tissues by reverse transcription-quantitative polymerase chain reaction. In addition, following transfection with an miR-421 inhibitor to suppress the expression of miR-421, the proliferation, migration and cell cycle distribution of human gastric carcinoma MKN28/MKN74 cells were determined by cell counting, Transwell and flow cytometry assays. The target gene of miR-421 was also predicted using bioinformatic analysis and verified by dual-luciferase reporter gene assay and western blot analysis. Furthermore, overexpression of the miR-421 target protein was induced in MKN28/MKN74 cells to determine its function. It was observed that miR-421 was significantly upregulated in gastric cancer tissues and that the expression of miR-421 was associated with lymph node metastasis and the clinical stage of gastric cancer (all P<0.05). Claudin11 (CLDN11) was predicted and verified as a direct target of miR-421. In vitro experiments demonstrated that inhibition of miR-421 expression suppressed the proliferation and metastasis of MKN28/MKN74 cells and induced G1/S-phase cell cycle arrest (all P<0.05). Analagous results were observed in MKN28/MKN74 cells following overexpression of the CLDN11 protein. Collectively, these data suggest that miR-421 may promote the proliferation, invasion and metastasis of gastric cancer by inhibiting the expression of CLDN11.

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Gastric Metastasis of Triple Negative Invasive Lobular Carcinoma

Cited by 13 publications

References 14 publications

Breast cancer metastases to the stomach and colon mimicking primary gastrointestinal cancer: Four cases and literature review

Breast cancer metastases to the stomach and colon mimicking primary gastrointestinal cancer: Four cases and literature review

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11

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