Gastric microbiota dysbiosis and Helicobacter pylori infection

Zhang, Ling; Zhao, Ming; Fu, Xiangsheng

doi:10.3389/fmicb.2023.1153269

Cited by 8 publications

(7 citation statements)

References 123 publications

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“…The intestinal microbiota of H. pylori -positive GC patients is also transformed, and this may further contribute to GC ( Gao et al, 2018 ; Dash et al, 2019 ; Seol et al, 2019 ; Iino and Shimoyama, 2021 ). Modulation of the gastrointestinal microbiota is beneficial to the eradication of H. pylori and the treatment of gastric diseases related to microbial dysbiosis ( Viazis et al, 2022 ; Musazadeh et al, 2023 ; Zhang L. et al, 2023 ). The study of specific strains or pathogenic pathways of non- H. pylori bacteria in GC progression is helpful in identifying relevant treatment measures accordingly.…”

Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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BackgroundNumerous studies have cast light on the relationship between the gastric microbiota and gastric carcinogenesis. In this study, we conducted a bibliometric analysis of the relevant literature in the field of gastric cancer and the gastric microbiota and clarified its research status, hotspots, and development trends.Materials and methodsPublications were retrieved from the Web of Science Core Collection on 18 July 2023. CiteSpace 6.2.R4, VOSviewer 1.6.19.0, and Biblioshiny were used for the co-occurrence and cooperation analyses of countries, institutions, authors, references, and keywords. A keyword cluster analysis and an emergence analysis were performed, and relevant knowledge maps were drawn.ResultsThe number of published papers in this field totaled 215 and showed an increasing trend. The analysis of funding suggested that the input in this field is increasing steadily. China had the highest number of publications, while the United States had the highest betweenness centrality. Baylor College of Medicine published the most articles cumulatively. Both Ferreira RM and Cooker OO had the highest citation frequency. The journal Helicobacter showed the most interest in this field, while Gut provided a substantial research foundation. A total of 280 keywords were obtained using CiteSpace, which were primarily focused on the eradication and pathogenic mechanisms of Helicobacter pylori, as well as the application of the gastric microbiota in the evaluation and treatment of gastric cancer. The burst analysis suggested that in the future, research may focus on the application of gastric microorganisms, particularly Fusobacterium nucleatum, in the diagnosis and treatment of gastric cancer, along with their pathogenic mechanisms.ConclusionCurrent studies have been tracking the eradication of Helicobacter pylori and its pathogenic mechanisms, as well as changes in the gastric microbiota during gastric carcinogenesis. Future research may focus on the clinical application and pathogenesis of stomach microorganisms through bacteria such as Fusobacterium nucleatum.

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Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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“…Firmicutes (e.g., Staphylococcus ) are the primary producers, while Bacteroidetes generate it infrequently ( Fennema et al, 2016 ). Overall, probiotics may raise the proportion of helpful metabolite-producing bacteria and/or lower the number of detrimental metabolite-producing bacteria ( Zhang et al, 2023 ). Probiotics can help repair the stomach dysbiosis produced by eradication therapy, however, young adults infected with H. pylori may not need to take probiotics alone ( Yuan et al, 2021 ).…”

Section: Alternative Therapiesmentioning

confidence: 99%

A review for non-antibiotic treatment of Helicobacter pylori: new insight

Shadvar,

Akrami,

Mousavi Sagharchi

et al. 2024

Front. Microbiol.

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Gastric ulcers and gastric cancer are brought on by the Helicobacter pylori bacteria, which colonizes under the stomach mucous membrane. Different medication regimens are used to remove it, but the illness returns and becomes more resistant, which lowers the treatment rates. Additionally, this bacterium now exhibits a skyrocketing level of multi-drug resistance, necessitating recurrent therapeutic treatments. The negative effects of synthetic medications in comparison to conventional therapies are another significant factor in favor of non-pharmacological therapy. The most significant side effects of popular anti-gastric ulcer medications include nausea, vomiting, and diarrhea. Stomach ulcers have previously been treated with herbal remedies and complementary treatments like probiotics. When probiotics are ingested, the host experiences several advantages that may be brought about by altering the bacterial flora in the digestive system. Additionally, stronger-acting chemical compounds and plant extracts can be employed to treat patients. In this article, we look at the substances and medications that are utilized in place of synthetic stomach ulcer-curing treatments.

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“…Gastrointestinal infections, such as Helicobacter pylori infection and foodborne illnesses, have also been linked to dysbiosis [27][28][29]. H. pylori is a bacterium that colonizes the stomach and is associated with various gastrointestinal disorders, including gastric ulcers and stomach cancer.…”

Section: Microbiome Dysbiosis and Infectious Diseasesmentioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

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Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.

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Gastric microbiota dysbiosis and Helicobacter pylori infection

Cited by 8 publications

References 123 publications

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

A review for non-antibiotic treatment of Helicobacter pylori: new insight

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

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