Gastric Myeloid Sarcoma

Marcos, Pedro; Atalaia-Martins, Catarina; Barbeiro, Sandra; Fernanda-Cunha, Maria; Eliseu, Liliana; Vasconcelos, Helena Baldez

doi:10.1159/000504761

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…In our patient and in the literature, gastric MS is typically a nodular and ulcerated mass or lesion, compared with gastric cancers that are typically friable, ulcerated masses, although they can also present as malignant ulcers. [10][11][12] GISTs and leiomyomas typically appear as submucosal lesions with smooth margins and the normal overlying mucosa. Central ulceration is occasionally present.…”

Section: Discussionmentioning

confidence: 99%

Gastric Myeloid Sarcoma

Shaikh,

Almanza Huante,

Taherian

et al. 2023

ACG Case Rep J

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Most gastric cancers are adenocarcinomas, but other malignancies can arise in the stomach. Patients with leukemia may develop myeloid sarcoma (MS) in the gastrointestinal tract. Our patient was a 68-year-old woman who was initially diagnosed with acute myeloid leukemia and underwent a matched unrelated stem cell transplantation. She was in remission for 10 years before developing a rare case of gastric MS without acute myeloid leukemia. She had partial response to chemotherapy but ultimately died because of infection. Gastric MS has an incidence of less than 1%. Gastrointestinal involvement usually involves the small intestine and rarely the stomach.

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Section: Discussionmentioning

confidence: 99%

Gastric Myeloid Sarcoma

Shaikh,

Almanza Huante,

Taherian

et al. 2023

ACG Case Rep J

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“…Occurrences in the gastrointestinal tract are rare, accounting for approximately 10% of cases, with the majority of these occurring in the intestine. Occurrences in the stomach are especially rare 2…”

Section: Introductionmentioning

confidence: 99%

Rapid progression from MDS to AML with gastric submucosal tumour as an extramedullary infiltration

Kobayashi,

Umekawa

2024

BMJ Case Rep

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We present a rare case of myeloid sarcoma in the stomach of an elderly woman initially diagnosed with anaemia. Myeloid sarcoma, an unusual extramedullary manifestation of acute myeloid leukaemia (AML), primarily affects lymph nodes, bones, spine and skin, with gastrointestinal involvement being infrequent. Despite normal results from the initial endoscopy, a follow-up examination after 4 months revealed multiple submucosal gastric tumours. These developments coincided with worsening of anaemia and an increase in peripheral myeloblasts. Pathological evaluation and immunohistochemical staining confirmed gastric extramedullary infiltration associated with AML. This case highlights the importance of comprehensive diagnostic processes when suspecting leukaemic transformations, especially in myelodysplastic syndrome (MDS). Due to financial constraints, additional critical studies such as cytogenetics and next-generation sequencing were not performed. Nonetheless, this rare case demonstrates the visual observation of rapid progression from MDS to AML and concurrent early myeloid sarcoma development in an elderly patient.

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Gastric Myeloid Sarcoma

Cited by 2 publications

References 5 publications

Gastric Myeloid Sarcoma

Gastric Myeloid Sarcoma

Rapid progression from MDS to AML with gastric submucosal tumour as an extramedullary infiltration

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