Gastric Secretion in Hypothyroid Adult Rats During the Infusion of Histamine for 24 Hours

Kowalewski, K.

doi:10.1159/000201615

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…This dose, therefore, was used in the present study. In all cases, the rate of fluid infusion was identical and gastric content was collected for 24 h [10,11,12,14]. Uniform infusion was obtained using the " Infusion Withdrawal Pump" (Harvard Apparatus Co., USA).…”

Section: Methodsmentioning

confidence: 99%

Influence of Dietary Fat on Histamine Stimulated Gastric Secretion in Rats

Kowalewski¹

1969

Digestion

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Gastric secretory function was studied for 24 h in rats bearing permanent gastric fistulas and permanent intra-venous cannulas. Rats were fed normal, fat free and rich fat diets for three months prior to collection of gastric content. Saline or histamine in saline were infused intravenously for 24 h during the collection period. Feeding fat rich diet induced the significant depression of histamine stimulated gastric secretion.The absence of normal post-histaminic increase of gastric secretory function in ratsfed fat rich diet is considered due to “work hypoplasia”, resulting from prolongedand repeated inhibition of secretory function of parietal cells.

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Section: Methodsmentioning

confidence: 99%

Influence of Dietary Fat on Histamine Stimulated Gastric Secretion in Rats

Kowalewski¹

1969

Digestion

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Myoelectrical and mechanical activity of stomach and intestine in hypothyroid dogs

Kowalewski

Kolodej

1977

Digest Dis Sci

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Myoelectrical activity was studied in normothyroid and hypothyroid Labrador dogs in the resting state, following injection of pentagastrin, bethanechol chloride, and after feeding. Hypothyroidism was produced by total thyroidectomy and chronic treatment with thiouracil. Electrodes were surgically implanted over the serosa of the stomach, duodenum, jejunum, and ileum and used for repeated recording of myoelectrical activity of gastrointestinal muscles. A strain gauge was implanted over the gastric antrum and served to record mechanical activity of the stomach. As compared with control dogs, hypothyroid animals showed (a) decreased frequency of electrical control activity of the stomach and jejunum, (b) decreased occurrence of electrical response activity (spike potentials) following stimulation, and (c) decreased mechanical response to the same stimulants, ie, pentagastrin, bethanechol chloride, and food.

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Effect of L-thyroxine on secretory response to histamine in ex vivo canine stomach perfused with homologous blood of thyroidectomized dog

Kowalewski

Kolodej

1973

Digest Dis Sci

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Gastric Secretion in Hypothyroid Adult Rats During the Infusion of Histamine for 24 Hours

Cited by 6 publications

References 6 publications

Influence of Dietary Fat on Histamine Stimulated Gastric Secretion in Rats

Influence of Dietary Fat on Histamine Stimulated Gastric Secretion in Rats

Myoelectrical and mechanical activity of stomach and intestine in hypothyroid dogs

Effect of L-thyroxine on secretory response to histamine in ex vivo canine stomach perfused with homologous blood of thyroidectomized dog

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