Gastric ulcer and the anti-arthritic drugs

Emmanuel, Julian; Montgomery, R. D.

doi:10.1136/pgmj.47.546.227

Cited by 39 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most anti-inlammatory drugs and antiarthritic drugs have wide applications in clinical conditions [10], and they are associated with several side efects such as gastrointestinal tract complications, ulcers, and cardiovascular problems [11,12]. Therefore, alternative therapies from natural resources are ventured throughout the world.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Potential Anti-Inflammatory Activity of Extracts from Calendula arvensis (CA) Flowers

Abudunia¹,

Kamal²,

Ziad³

et al. 2017

Nonsteroidal Anti-Inflammatory Drugs

View full text Add to dashboard Cite

Calendula arvensis (CA) had been reported in traditional Moroccan medicine to exhibit its extensive use to treat pain and inlammation. Therefore, the objective of this study was to evaluate the anti-inlammatory activity of CA lowers. The methanol, aqueous, and hexane extracts (ME, AE, and HE) were investigated for inlammatory efects by using two methods, namely, carrageenan and experimental trauma-induced hind paw edema in rats and using indomethacin (20 mg/kg body weight) as a standard drug. The results demonstrated that Calendula Arvensis CA extracts had signiicant anti-inlammatory activity where the HE at the doses of 300 and 500 mg/kg p.o. (p < 0.001) had the best signiicant reduction and inhibition of edema with 51.08, 71.33 and 63.38, 67.33% induced by carrageenan and on experimental trauma induced rat paw edema at third hour, respectively, and similar as compared with standard drug indomethacin 20 mg/kg body weight p.o.(p < 0.001). These results indicate that it could be suggested as contributory efects to the use of CA lowers in the management of inlammation and pain conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

In Vivo Potential Anti-Inflammatory Activity of Extracts from Calendula arvensis (CA) Flowers

Abudunia¹,

Kamal²,

Ziad³

et al. 2017

Nonsteroidal Anti-Inflammatory Drugs

View full text Add to dashboard Cite

show abstract

“…As we have shown, well-matched controls are needed with regard to age and sex because of the differences in ulcer behaviour. Addition ally, there may be an inherent tendency to GU in rheumatoid disease [9,22,23] but, not surprisingly, there have been no controlled studies in the absence of treatment. Kurata et al [24] emphasized the statistical inadequacy of all published data.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis of GU during 1963-1975 was primarily radiological, whereas in the recent series 86% were examined by endoscopy and 64% by air-contrast radiology. As part of a continuing study [9], all patients were questioned as to a history of reg ular NANSAD treatment for at least 1 month prior to the diagnosis of GU. 45 such patients were identified -17 in the first series and 28 in the second.…”

Section: Methodsmentioning

confidence: 99%

Changing Clinical Pattern of Gastric Ulcer: Are Anti-Inflammatory Drugs Involved?

Jolobe¹,

Montgomery²

1984

Digestion

View full text Add to dashboard Cite

The changing pattern of gastric ulcer (GU) has been studied in a series of 528 cases presenting in one hospital department during the past 20 years. The male:female ratio has declined and is now equal, and age-adjusted figures show that this applies to all age groups. There was a significant decline in mid-gastric ulcers in men. There was a 4-fold increased incidence of haemorrhage in proximal as opposed to antral ulcers and a 7-fold excess of haemorrhage in older women as opposed to younger women. GU in elderly women taking non-aspirin non-steroidal anti-inflammatory drugs (NANSADs) showed an increased tendency to bleeding, accounting for half of all haemorrhages in women over 70 years. However, on statistical analysis NANSAD-associated ulcers showed no other distinguishing features, and the use of NANSADs did not contribute significantly to the changing sex ratio. There is still no satisfactory evidence that these drugs play a causal role in chronic GU.

show abstract

“…The incidence or severity of gastrointestinal ulceration due to NSAIDs (Johnson & Day 1991b) may be increased by the concomitant administration of corticosteroids (Emmanuel & Montgomery 1971;Verbeeck 1990), with a relative risk for developing peptic ulcer disease of 4.4 (confidence interval 2.0-9.7) in patients on NSAIDs and corticosteroids concurrently (Piper et al 1991). …”

Section: Corticosteroidsmentioning

confidence: 99%

Adverse Drug Interactions with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

1993

View full text Add to dashboard Cite

The prevalence and incidence of adverse drug interactions involving nonsteroidal anti-inflammatory drugs (NSAIDs) remains unknown. To identify those proposed drug interactions of greatest clinical significance, it is appropriate to focus on interactions between commonly used and/or commonly coprescribed drugs, interactions for which there are numerous well documented case reports in reputable journals, interactions validated by well designed in vivo human studies and those affecting high-risk drugs and/or high-risk patients. While most interactions between NSAIDs and other drugs are pharmacokinetic, NSAID-related pharmacodynamic interactions may be considerably more important in the clinical context, and prescriber ignorance is likely to be a major determinant of many adverse drug interactions. Prescribing NSAIDs is relatively contraindicated for patients on oral anticoagulants due to the risk of haemorrhage, and for patients taking high-dose methotrexate due to the dangers of bone marrow toxicity, renal failure and hepatic dysfunction. Combination NSAID therapy cannot be justified as toxicity may be increased without any improvement in efficacy. Where lithium or anti-hypertensives are coprescribed with NSAIDs, close monitoring is mandatory for lithium toxicity and hypertension, respectively, and aspirin (acetylsalicylic acid) or sulindac are preferred. Phenytoin or oral hypoglycaemic agents may be administered with NSAIDs other than pyrazoles and salicylates provided that patients are monitored carefully at the initiation and cessation of NSAID treatment. Digoxin, aminoglycosides and probenecid may be coprescribed with NSAIDs, but close monitoring is required, particularly for high-risk patients such as the elderly. Indomethacin and triamterene should be avoided due to the risk of renal failure. High dose aspirin should be replaced by naproxen in patients on valproic acid (sodium valproate) and care is required when corticosteroids are administered to patients taking salicylates long term in high dosage. Interactions between NSAIDs and antacids or cholestyramine are generally avoidable. Adverse drug interactions involving NSAIDs may be limited by rational prescribing and by careful monitoring, particularly for high-risk patients, drugs and therapy periods.

show abstract

Gastric ulcer and the anti-arthritic drugs

Cited by 39 publications

References 44 publications

In Vivo Potential Anti-Inflammatory Activity of Extracts from Calendula arvensis (CA) Flowers

In Vivo Potential Anti-Inflammatory Activity of Extracts from Calendula arvensis (CA) Flowers

Changing Clinical Pattern of Gastric Ulcer: Are Anti-Inflammatory Drugs Involved?

Adverse Drug Interactions with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Contact Info

Product

Resources

About