Gastritis Associated with Initially Pediatric Crohn's Disease and Ulcerative Colitis

Abstract

PurposeThe aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn's disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to compare their differences.MethodsThis study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogastroduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined.ResultsIn our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diagnosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD-diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03).ConclusionThe results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD-diagnosed patients.

Association of Inflammatory Pathologies and Crohn's Disease: A Retrospective Study in the West Algerian Region

“…Of these, 7.1% are peritonitis, 2.4% are gastritis, 1.7% are UC, 0.7% are villous atrophy and COPD. These results are similar to those of 19,20 . We also found 0.3% cases of meningitis and 01% of appendicitis in the under 20 age group with a significant rate.…”

Prevalence and Clinical Significance of Helicobacter Pylori‐negative Chronic Gastritis in Children

“…One explanation for the temporal change from H pylori‐ positive to H pylori ‐negative in the distribution of pediatric gastritides reflected in the aforementioned studies could be the rising prevalence of pediatric IBD (31–33) and celiac disease (34–36), in which HPNCG is known to be a common finding (5–7,37–39). We found both forms of HPNCG were associated with Crohn disease and the inactive form was also associated with celiac disease and ulcerative colitis.…”

Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review

“…The esophageal involvement of these patients consists of active esophagitis, chronic esophagitis (including LE), and reflux esophagitis[8,9,15]. The inflammatory patterns seen in the stomach include chronic active and inactive gastritis (including Helicobacter pylori -associated gastritis), chronic atrophic gastritis, and FEG[10,16,17]. The duodenal inflammation is characterized by crypt inflammation, villous blunting, and increased intraepithelial lymphocytes[18].…”