Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages and laboratory assessment in Algerian patients with Rheumatoid arthritis, as well as their importance like a predictive factor for the diagnosis of Rheumatoid arthritis (RA). Methods: 281 patients diagnosed with RA according to ACR 1987 criteria in the  internal medicine and Functional Rehabilitation departments (the University Hospital of Sidi Bel Abbes) were enrolled in the study based on medical records including age, gender, disease duration, disease activity score (DAS28), joint damages, laboratory tests and treatment. All data were processed and analyzed via SPSS 22.0. Results: 86.5% of patients were females with a mean age and disease duration of respectively 52.665±12.3477, 4.19±4.050.  Patients with Anti-CCP positive (79.7%) presented a high disease activity (p<0.0001), a long disease duration (p=0.016) and a erosion damages (p<0.0001). we did not found any significant relation between gender, hands damages and CRP..A logistic regression showed that the presence of Anti-CCP was associated with Erosion, disease activity, age and RF presence. Conclusion: There was a strong relation between Anti-CCP antibodies status and the development of RA in Algerian patients. It could be considered as a useful predictor of disease severity.

Introduction Autism is a neurodevelopmental disorder that manifests before 3 years old and affects many areas, communication, social interactions and behaviors. In Algeria, there has not yet been a regional or national epidemiological investigation concerning autism spectrum disorders. Materials and methods: Our study was carried about 100 patients ( autistic children) in the western region of Algeria, in order to determine the differents risk factors involved in the onset of autism syndrome. Results and discussion: The obtained results indicate a male predominance with a sex ratio of 4: 1 and the degree of reached is average in 44% of patients. 42% of the patients are youngsters. Parents' worry about their children begins  between 24 and 36 months. The parents' advanced age at conception, stress, presence of certain pathologies and drug intake by mothers, as well as fetal distress at birth and children's exposure to screens were the main risk factors. Repetitive movements, lack of social communication, language delay, and lack of visual fixation were the main clinical symptomatology. Conclusion: This study allowed us to detect the main factors associated with the onset of autism. However, the results obtained cannot be generalized to the entire population. Keywords: Autism, autism spectrum disorder, risk factors, clinical symptoms, western region of Algeria.

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Background: This study aimed to demonstrate the gender and age-at-onset differences in rheumatoid arthritis (RA) in the western Algerian population and their impacts on patients' clinical features and medical management. Methods: A retrospective cross-sectional study was carried out at the Internal Medicine and Functional Rehabilitation Departments (University Hospital of Sidi-bel-Abbes region) based on medical records of over 306 RA patients diagnosed between 2016 and 2019 according to ACR 1987 criteria. Late-onset RA (LORA) was defined as disease onset at 51 years of age or older. All data were processed and analyzed via SPSS 22.0. Results: We enrolled 306 rheumatoid arthritis patients (85% women) with a mean age-at-onset of 52.47 ± 12.14. Algerian RA women were more at risk of developing type 2 diabetes (P = 0.035), hypertension (P = 0.003), and thyroid disorders (P = 0.05). We did not find any significant relationship between clinical features, laboratory data, and gender. The LORA group comprised 60.5% of our study population with a higher number of comorbidities such as hypertension (P < 0.001), osteoporosis (P = 0.007), and scleroderma (P = 0.014). Nonetheless, we found evidence of an association between positive anti-CCP, RF rate, and age-at-onset (P = 0.001 and P < 0.001, respectively). Conclusions: Algerian RA women with LORA presented a higher prevalence of comorbidities, while Young-onset RA (YORA) was associated with a high rate of RF.

Background: Systemic lupus erythematosus is the most severe autoimmune inflammatory diseases prototype. It is characterized by a large clinical polymorphism under the influence of genetic, immunological and environmental factors, affecting more likely women during genital activity periods. Objective: The aim of our investigation is to determine and specify the epidemiological, clinical, immunological, therapeutic and evolutionary profile of SLE in Algerian population.Patients and methods: A retrospective multicenter study was conducted on 194 lupus patients diagnosed at a higher age according to ACR and SLICC criteria, covering a period of 13 years (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019). The medical records were selected from the archive data for hospital stays and by a prospective listing of patients followed in consultation. Results:The mean diagnosis age of our patients was (29.66±12.84). The most frequent clinical manifestations were cutaneous 71.1%, articular 74.7% and hematological 71.6%. 26.3% of the patients had nephropathies. The positive titer of antinuclear antibodies was 94.4%, anti-DNAn 66.7%, anti-Sm, RNP, SSA, and SSB in 31.5, 21, 39.5, and 19.8% of cases respectively. The secondary anti-phospholipid syndrome was associated with 15.4% of patients. Other autoimmune diseases associated with SLE and positive family history were detected in 97.93% and 34.53% of patients respectively. While confirming the clinical polymorphism of SLE. Conclusion: The clinical polymorphism of SLE is confirmed by our study, its severity and complexity and even the great similarities with the differences series of literature around the world, urges us to continue research to improve therapeutics for a better prognosis through early management and to enhance the life expectancy of patients.