Gastro-oesophageal reflux and idiopathic pulmonary fibrosis: in search of evidence

Wuyts, Wim; Crestani, Bruno

doi:10.1183/13993003.01444-2016

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Gastroesophageal re ux disease (GERD) is a prevalent condition that affects approximately 20% of adults in developed countries, and can result in various uncomfortable symptoms and/or complications within and outside the esophagus [6]. Numerous studies have reported that GERD is a common complication of IPF [7][8][9][10], with multiple cohort studies and meta-analyses con rming the close relationship between both conditions [11][12][13][14]. Although the discussion regarding the potential relationship between GERD and IPF can be traced back to the 1970s [15], the connection between the two remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Causal analysis of the association between gastroesophageal reflux disease and idiopathic pulmonary fibrosis

Chen

Gong²,

Liu

et al. 2023

Preprint

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Background: Recent observational studies have provided evidence of a close association between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF). However, determining the causal relationship between these two conditions remains a challenge. In this study, we employed Mendelian randomization (MR), a genetic method using genome-wide association studies (GWAS), to investigate the causal relationship between GERD and IPF. Methods: In order to evaluate the causality of GERD in IPF, multiple MR methods were employed utilizing the GWAS databases of GERD from 473,524 individuals and of IPF from 451,025. Sensitivity analysis was performed to evaluate the robustness of MR results. Additionally, multi-variant Mendelian randomization (MVMR) was utilized to evaluate potential confounding factors. Results: We found a significant causal relationship between GERD and IPF (odds ratio [OR]: 1.002, 95% confidence interval [CI]: 1.001–1.003, P <0.001). This finding was also supported by the Weighted median analysis (OR: 1.002, 95% CI: 1.002–1.003, P =0.021). The sensitivity analysis did not reveal any significant deviation from the main results. Furthermore, MVMR analysis demonstrated that GERD significantly increased the risk of IPF, even after controlling for possible confounding factors (OR: 1.001, 95% CI: 1.001–1.003, P =0.04). Conclusions: The results of our study provide strong evidence of a causal relationship between GERD and IPF. Based on these findings, it is recommended that interventions be implemented for individuals with GERD to prevent the development of IPF.

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Section: Introductionmentioning

confidence: 99%

Causal analysis of the association between gastroesophageal reflux disease and idiopathic pulmonary fibrosis

Chen

Gong²,

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Gastroesophageal reflux is particularly frequent in IPF and may contribute to repeated alveolar epithelium injury and lung fibrosis progression [3]. Anti-reflux therapy, including proton pump inhibitors and anti-reflux surgery, have been suggested to influence the progression of lung function decline and exacerbation rate in IPF patients [4,5] although this remains a matter of debate in the absence of any direct evidence from randomized trials [6,7]. Interestingly, recent observations indicate that proton pump inhibitors may have antifibrotic activities by directly suppressing proinflammatory cytokines, profibrotic proteins, and proliferation of lung fibroblasts [4].…”

Section: Introductionmentioning

confidence: 99%