Gastro‐oesophageal reflux disease in chronic laryngitis: prevalence and response to acid‐suppressive therapy

Qua, Choon‐Seng; Wong, Choon-Heng; K, Gopala; Goh, Khean Lee

doi:10.1111/j.1365-2036.2006.03185.x

Cited by 59 publications

(63 citation statements)

References 33 publications

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“…The causal association between acid reflux and laryngitis is highly plausible considering the close anatomical relationship. The vagally mediated reflexes (bronchospasm, laryngospasm and cough) stimulated by esophageal acid is also implicated in the pathogenesis of GERD-related extra-esophageal disorder [11,15] . Currently, there is no "gold-standard" for the diagnosis of LPR.…”

Section: Discussionmentioning

confidence: 99%

“…Patients were excluded from the study if they had a history of respiratory or gastrointestinal malignancy; radiation therapy to the head and neck, lung, or gastrointestinal tract; gastroesophageal surgery; use of H 2 -receptor antagonists or proton pump inhibitors in previous 1 mo; past or present smoker; excessive alcohol consumption; chronic cough attributable to known chronic pulmonary or tracheobronchial disease; professional voice users (e.g. singer, teacher); excessive voice use; exposure to occupational or environmental pollutants; history of seasonal allergic rhinitis; pharyngolaryngeal infection in the previous 3 mo; tracheal intubation in the previous 12 mo and use of inhaled corticosteroids [10,11] .…”

Section: Recruitment Of Patientsmentioning

confidence: 99%

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Laryngopharyngeal reflux in patients with reflux esophagitis

Lai

Wang²,

Lin³

2008

WJG

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Section: Discussionmentioning

confidence: 99%

Section: Recruitment Of Patientsmentioning

confidence: 99%

Laryngopharyngeal reflux in patients with reflux esophagitis

Lai

Wang²,

Lin³

2008

WJG

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“…The association between gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) is well established, and extra-esophageal symptoms, eg, hoarseness and globus sensation, improve with acid suppression. 4 A systematic review found an increased risk of chronic cough in patients with GERD (odds ratio, 1.7; 95% CI, 1.4 -2.1), 5 and a national cross-sectional postal survey in Scotland found a 31% prevalence of sore throat.…”

mentioning

confidence: 99%

Nasolaryngoscopy in a Family Medicine Clinic: Indications, Findings, and Economics

Wilkins¹,

Gillies²,

Getz³

et al. 2010

The Journal of the American Board of Family Medicine

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Background: Nasopharyngeal complaints are common among patients who present to primary care. Patients with these complaints are often referred for nasolaryngoscopy evaluation to exclude serious conditions such as laryngeal cancer.Methods: This study is a retrospective case series in which 276 charts of adult outpatients who were referred for nasolaryngoscopy were reviewed. We examined patient demographics, procedure indications and findings, complications, and changes in clinical management.Results: Nasolaryngoscopy was completed in 273 (98.9%) patients (mean age, 51.3 ؎ 14.6 years; 71.4% were women). The most common indications for nasolaryngoscopy were hoarseness (51.3%), globus sensation (32.0%), and chronic cough (17.1%); the most common findings included laryngopharyngeal reflux (42.5%), chronic rhinitis (32.2%), and vocal cord lesions (13.2%). Three patients (1.1%) were diagnosed with laryngeal cancer and this diagnosis was significantly associated with a history of smoking (P ‫؍‬ .03). No major complications occurred.Conclusions: We found that nasolaryngoscopy was a safe procedure in the primary care setting, and no major complications occurred in our series. Patients who have ever smoked and complain of hoarseness are at higher risk for laryngeal cancer. An alarming 1% of patients in our series were diagnosed with laryngeal cancer. This is the first study to define the rates of laryngopharyngeal reflux, vocal cord lesions, and laryngeal cancer among primary care patients. (J Am Board Fam Med 2010;23:591-597.)

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“…Various modifi cations of the Laryngeal Symptom Score (LSS) have been used in some studies (Williams et al 2004;Wo et al 2006;Qua et al 2007). The frequency and severity of a number (usually up to 6) of LPR symptoms are assessed over the preceding week to give a cumulative score.…”

Section: Patient Reported Outcomes In Laryngopharyngeal Refl Uxmentioning

confidence: 99%

Management of laryngopharyngeal reflux with proton pump inhibitors

Reimer

Bytzer²

2008

TCRM

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Abstract:There is a lack of consistent guidelines and consensus for the diagnosis of laryngopharyngeal refl ux (LPR). A therapeutic trial with a proton pump inhibitor (PPI) has been suggested to identify patients with LPR. This review focuses on the current diffi culties in diagnosing the disease and examines the evidence for the effectiveness of PPI therapy in suspected refl ux-related laryngeal symptoms. Additionally, mode of action, safety, and tolerability of PPIs are described. A total of 7 placebo-controlled trials were identifi ed and included in the review. All studies evaluated the effect of a PPI on symptoms and objective laryngoscopic fi ndings in suspected LPR. Data from these trials show that PPI therapy is no more effective than placebo in producing symptom relief in patients suspected of LPR. Symptoms, laryngoscopic fi ndings, or abnormal fi ndings on pH monitoring will not predict response to PPI therapy. High placebo response levels suggest a much more complex and multifactorial pathophysiology of LPR than simple acid refl ux. Further studies are needed to characterize subgroups of patients with refl ux-associated laryngeal symptoms that might benefi t from treatment with PPI. Future studies should use validated patient reported outcome measures with endpoints that represent a predefi ned clinically meaningful change in symptom scores.

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Gastro‐oesophageal reflux disease in chronic laryngitis: prevalence and response to acid‐suppressive therapy

Abstract: SUMMARY BackgroundGastro-oesophageal reflux is thought to cause chronic laryngitis through laryngopharyngeal reflux. Response of laryngitis to treatment with acid-suppressive therapy supports this causal link.

Cited by 59 publications

References 33 publications

Laryngopharyngeal reflux in patients with reflux esophagitis

Laryngopharyngeal reflux in patients with reflux esophagitis

Nasolaryngoscopy in a Family Medicine Clinic: Indications, Findings, and Economics

Management of laryngopharyngeal reflux with proton pump inhibitors

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