Laryngopharyngeal reflux in patients with reflux esophagitis

Lai, Yu‐Ling; Wang, Pa‐Chun; Lin, Jun-Chen

doi:10.3748/wjg.14.4523

Cited by 32 publications

(26 citation statements)

References 30 publications

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“…There is still significant controversy etiopathogenesis of LPR. LPR might not only occur with gastro-oesophageal reflux but also with impaired clearance of luminal contents which is responsible for extra-esophageal manifestations [20]. The vagally mediated reflexes (bronchospasm, laryngospasm and cough) is also implicated in the pathogenesis of GERD-related extra-esophageal disorder.…”

Section: Discussionmentioning

confidence: 99%

Relationship between history, laryngoscopy and esophagogastroduodenoscopy for diagnosis of laryngopharyngeal reflux in patients with typical GERD

Vardar

Varis

Bayrakçi

et al. 2011

Eur Arch Otorhinolaryngol

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The techniques used in the diagnosis of gastroesophageal reflux disease (GERD) have insufficient specificity and sensitivity in diagnosing laryngopharyngeal reflux (LPR). The purpose of this study was to evaluate the role of esophagogastroduodenoscopy (EGD) and laryngological examination in the diagnosis of LPR. A total of 684 diagnosed GERD and suspected LPR patients were prospectively scored by the reflux finding score (RFS) which was suggested by Koufman. A total of 484 patients with GERD who had RFS ≥ 7 were accepted as having LPR. 248 patients with GERD plus LPR on whom an endoscopic examination was performed were evaluated. As a control group, results from 82 patients with GERD who had RFS <7 were available for comparison. The GERD symptom score (RSS) was counted according to the existence of symptoms (heartburn/regurgitation) and frequency, duration, and severity. The reflux symptom index (RSI) suggested by Belafsky et al. was also evaluated. The relationship between esophageal endoscopic findings, RSS, RFS and RSI was investigated. Mean age was 46 ± 12 (19-80). The mean values of RSS, RFS, and RSI were 18.9 ± 7.7, 10 ± 2.2, 16.6 ± 11.9, respectively. Erosive esophagitis was detected in 75 cases (30%). Hiatus hernia was observed in 32 patients (13%). There was no correlation between RSS and RFS, RSI. The severity of esophagitis did not correlate with the severity of the laryngeal findings. LPR should be suspected when the history and laryngoscopy findings are suggestive of the diagnosis. EGD has no role in the diagnosis of LPR.

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Section: Discussionmentioning

confidence: 99%

Relationship between history, laryngoscopy and esophagogastroduodenoscopy for diagnosis of laryngopharyngeal reflux in patients with typical GERD

Vardar

Varis

Bayrakçi

et al. 2011

Eur Arch Otorhinolaryngol

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“…Laryngoscopy findings and histological results showed that significant differences occurred in the rabbits 8 weeks after total myectomy surgery compared to before the surgery. These findings are supported by several studies which indicate that LPR might be an extra-esophageal manifestation of GER [5][6][7]. Belafsky et al [16] suggested that LPR may be a possible cause for the treatment failures of esophagopharyngeal reflux, which implies a close relationship between GER and LPR.…”

Section: Discussionmentioning

confidence: 62%

“…One study found LPR in 23.9% of patients with reflux esophagitis, excluding other causes of laryngitis such as smoking, alcohol and excessive voice use [6]. As a silent animal, a rabbit seldom uses its vocal cords except for respiration, which suggests that gastric contents alone could cause laryngitis without other factors, such as smoking, alcohol or vocal cord abuse.…”

Section: Discussionmentioning

confidence: 98%

“…LES dysfunction results in esophageal pathological changes; however, whether it plays a role in LPR is controversial. For example, there are several studies that show that laryngeal symptoms are caused by extra-esophageal acid exposure, suggesting that LPR is an extra-esophageal manifestation of GER [5][6][7]. Conversely, other investigators have suggested that lower esophageal dysfunction is not necessarily associated with upper and lower airway pathology [8].…”

Section: Introductionmentioning

confidence: 93%

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Laryngoscopy findings and histological results in a rabbit gastroesophageal reflux model

Xü

Chen

et al. 2012

Eur Arch Otorhinolaryngol

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The role of lower esophageal sphincter (LES) in laryngopharyngeal reflux is controversial. In this study, we used an animal model to investigate the association between LES dysfunction and reflux laryngitis. Twelve healthy New Zealand albino rabbits (2.5-3.5 kg) were utilized in this study. The animals were divided into two groups. Eight rabbits underwent total cardiomyectomy to induce reflux, and the remaining four rabbits underwent a control sham operation. A laryngoscopy and a 24-hour intra-esophageal pH-metry were performed prior to surgery and again 2 and 8 weeks postsurgery. After the final laryngoscopy, all animals were sacrificed to obtain histological results. Total cardiomyectomy significantly increased the reflux index, the duration of the longest reflux episode and the total number of episodes that occurred in 24 h postsurgery. No significant difference was observed in the reflux finding score (RFS) between preoperative and 2-week postoperative rabbits (P = 0.11). But there was a statistically significant change in the RFS before and 8 weeks after the induction of reflux from 4.6 ± 0.9 to 8.3 ± 3.6 (P = 0.02). Submucous gland hyperplasia and inflammation were significantly increased in the reflux group compared to the control group. The results of this study suggest that chronic lower esophageal sphincter dysfunction is associated with reflux laryngitis in rabbits.

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“…Patients were excluded if they were older than 60 years and if they had (1) other factors that could lead to chronic laryngitis (smoking, alcohol, excessive voice use, allergies, asthma), (2) previous history of neck operation or trauma, (3) large thyroid mass, or (4) laryngeal paralysis or mass. Age-and sex-matched healthy volunteers with RSI \13 and RFS \7 constituted the control group.…”

Section: Clinical and Laryngoscopic Examinationmentioning

confidence: 99%

Cricopharyngeal Muscle Electromyography Findings in Patients with Gastroesophageal Reflux Disease

Alkan¹,

Demir²,

Yiğit³

et al. 2012

Otolaryngol.--head neck surg.

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Laryngopharyngeal reflux in patients with reflux esophagitis

Cited by 32 publications

References 30 publications

Relationship between history, laryngoscopy and esophagogastroduodenoscopy for diagnosis of laryngopharyngeal reflux in patients with typical GERD

Relationship between history, laryngoscopy and esophagogastroduodenoscopy for diagnosis of laryngopharyngeal reflux in patients with typical GERD

Laryngoscopy findings and histological results in a rabbit gastroesophageal reflux model

Cricopharyngeal Muscle Electromyography Findings in Patients with Gastroesophageal Reflux Disease

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