Gastro-protective effects of the phenolic acids of Macrotyloma uniflorum (horse gram) on experimental gastric ulcer models in rats

Study on the Anticoagulant or Procoagulant Activities of Type II Phenolic Acid Derivatives

“…Additionally, these phenolic compounds are important components of the human diet due to their potential antioxidant activities [ 1 , 2 ]. With immense research on pharmacological activity, phenolic acid compounds have shown many bioactivities, not only including familiar antioxidant [ 3 , 4 , 5 ], antibacterial [ 6 , 7 ], and anti-inflammatory [ 8 , 9 ] activities, but also haemostatic [ 10 , 11 ], anticancer [ 12 , 13 ], and antiviral [ 14 , 15 ] activities. Due to their excellent physical and chemical properties, phenolic acid compounds have aroused much attention and become one of the hotspots in drug development.…”

Ancient orphan legume horse gram: a potential food and forage crop of future

“…A proteinaceous protease inhibitors 'Hayanin' isolated from horse gram seed coats displayed significant antioxidant activity against different reactive oxygen species and effectively prevented hydroxyl and superoxide radicals (Lingaiah and Srinivas 2016). Horse gram extract also improved the concentration of antioxidant enzymes such as superoxide dismutase, catalase and glutathione in rabbits with high-fat diet-induced oxidative stress (Panda and Suresh 2015). Methanolic extract of horse gram significantly lowered the level of thiobarbituric acid reactive substances (TBARS) and enhanced the level of reduced glutathione in high-fat diet rabbits (Singhal et al 2014).…”

“…Phospholipids, sterol esters and sterols present in horse gram lipid are found to have gastroprotective properties as well as promote the healing of gastric ulceration (Tovey 2015). Phenolic acid (p-coumaric acid) in horse gram also exhibited antiulcer activity by attenuating the ulcer elevated levels of malondialdehyde and restored the ulcer depleted levels of reduced glutathione and the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidise and glutathione reductase (Panda and Suresh 2015), therefore, horse gram extracts could play an important role in protection against ulceration. Alcohol extracts of horse gram seeds exhibited potent anthelmintic activity comparable to standard piperazine citrate against Pheretima posthuma (Sree et al 2014) suggesting its use as dietary food for eradicating worms (Singh et al 2017a, b).…”

Gastroprotective Effect and Chemical Constituents of Flabellaria paniculata (Malpighiaceae)

“…Twenty fractions of 50 mL each were collected for each step and combined according to their thin-layer chromatography profiles, into 12 major fr. (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Fr.…”

“…The gastric ulcer production by indomethacin occurs since this compound inhibits the synthesis of cytoprotective prostaglandins, synthesized by cyclooxygenase 1 and cyclooxygenase 2 in stomach tissue, which in turn inhibits the release of mucus, a defensive factor against gastrointestinal damage. 9,10 The EtOAc fraction demonstrated significant protection of the gastric mucosa against damage caused by indomethacin compared to the control ( Figure 1). The mean ulcer index of the control group was 4.0 ± 0.5, while that of the EtOAc fr-treated groups at 50 and 100 mg/kg were 2.3 ± 0.4 and 1.0 ± 0.2, which corresponded to 42.5% and 75.0% inhibition, respectively.…”