Gastroenteropancreatic neuroendocrine neoplasms: a 10-year experience of a single center

Lewkowicz, Ewelina; Trofimiuk–Müldner, Małgorzata; Wysocka, K; Pach, Dorota; Kiełtyka, Agnieszka; Stefańska, Agnieszka; Sowa‐Staszczak, Anna; Tomaszewska, Romana; Hubalewska‐Dydejczyk, Alicja

doi:10.20452/pamw.2832

Cited by 25 publications

(38 citation statements)

References 18 publications

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“…Liver metastasis was the most common type of recurrence, whereas the spleen, kidney, and brain were relatively rare sites of recurrence. Our results were similar to previous reports [7]. In the present study, both the Ki-67 index and blood NLR were closely related to the site of tumor recurrence and a high incidence of liver metastasis was observed in patients with a high blood NLR or high Ki-67 index.…”

Section: Discussionsupporting

confidence: 93%

“…Deep tumor invasion, the presence of lymph node metastasis and distant metastasis, and a high Ki-67 index were associated with decreased long-term survival [6, 7, 20]. In this study, the rate of lymph node metastasis and the Ki-67 index were independent risk factors for OS and RFS in patients with g-NENs, which was consistent with previous reports.…”

Section: Discussionsupporting

confidence: 91%

“…The guidelines recommend that patients with g-NENs should be reevaluated 3 to 12 months after resection and then every 6 to 12 months for up to 10 years. However, the prognostic factors and surveillance strategy for patients with g-NENs have not been clearly defined due to the complexity and rarity of this disease [6, 7]. In recent years, the preoperative blood neutrophil-to-lymphocyte ratio (NLR) is considered to be significantly associated with oncological outcomes [8, 9], and an elevated NLR has been correlated with advanced stage and poor prognosis in a variety of human tumors, including colorectal cancer [10], gastric adenocarcinoma [11], non–small cell lung cancer [8], and hepatocellular carcinoma [12].…”

Section: Introductionmentioning

confidence: 99%

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A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms

Cao

Lü

et al. 2016

Oncotarget

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PurposeEvaluate the predictive value of the preoperative blood neutrophil-to-lymphocyte ratio (NLR) on the clinical outcomes of patients with gastric neuroendocrine neoplasms (g-NENs) after radical surgery.ResultsThe NLR was significantly higher in patients with g-NENs than in matched normal volunteers (P < 0.05). A higher blood NLR was not significantly associated with clinical characteristics (all P > 0.05). According to the multivariate analysis, the NLR was an independent prognostic factor of RFS and OS. Nomograms, including the NLR, Ki-67 index and lymph node ratio, had superior discriminative abilities to predict clinical outcomes. The recurrence rate was 37% (55/147). The median time to recurrence was 9 months; 48 (87%) patients experienced recurrence within the first 2 years. Both the NLR and Ki-67 index were correlated with liver metastases (both P < 0.05) and were also negatively correlated with recurrence time (both P < 0.05).Materials And MethodsWe enrolled 147 patients who were diagnosed with g-NENs and underwent radical surgery. Receiver operating characteristic curve analysis was used to identify the optimal value for blood NLR. Univariate and multivariate survival analysis were used to identify prognostic factors for g-NENs. A nomogram was adopted to predict RFS and OS after surgery.ConclusionsAs an independent prognostic factor for g-NENs, blood NLR can improve the predictability of RFS and OS. We recommend that g-NEN patients with a high blood NLR or high Ki-67 index undergo surveillance during the first month and then every 3 months for 2 years post-surgery.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms

Cao

Lü

et al. 2016

Oncotarget

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“…The acknowledged primary tumor site, grade and metastasis have been demonstrated as prognostic factors of NENs which are related to the 5-year survival rate [4, 5]. However, there is almost no other prognostic factor.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition

Bai

Hua

et al. 2016

Oncotarget

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Neuroendocrine neoplasms (NENs) represent relatively rare tumors. The lack of diagnostic, therapeutic method and prognostic factors makes them a challenge to us. We retrospectively reviewed the data of 205 NENs patients among which 157 cases were followed-up. Proprotein convertase subtilisin/kexin 9 (PCSK9), a regulator of low density lipoprotein cholesterol (LDL-C), was confirmed as a target gene of microRNA-224. We found an increased incidence of NENs from 2012 to 2015. Women were usually diagnosed at earlier stages than men (P < 0.05). Tumor grading was associated with primary tumor site, especially esophagus and cardia NENs all at G3 (P <0.001). Age, tumor grading and LDL-C levels were independent risk factors of digestive NENs. Low LDL-C level was significantly correlated with survival rate and median overall survival (OS, P < 0.05). MicroRNA-224 agomir and PCSK9 siRNA could promote apoptosis and suppress proliferation, invasion of BON-1 cells (P < 0.05), but increase the level of glucocorticoid (GC, P < 0.05). Taken together, age, tumor grading and LDL-C level are independent risk factors of NENs. The miR-224/PCSK9/GC axis binds to tumorigenesis and prognosis of pancreatic NENs (p-NENs).

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“…The ratios of metastatic rectal NEN patients were 5% in the SEER database [9], 8% in the Japanese registry [12], and 11.6% in the current study. Given that distant metastasis was one of the strongest prognostic factors of outcome [12,[20][21][22][23][24], differences in overall survival were also noted between colonic NENs and rectal NENs. In the SEER database, colonic NEN patients exhibited the worst prognosis among all GEP-NENs patients, with a 5-year overall survival rate of 41.6%.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms.

Jiang

Yuan

2017

JCO

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Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size ( < 0.0001) and distant metastasis ( < 0.0001). Colonic NENs had a worse prognosis ( = 0.027), with 5-year overall survival rates of 66.7% versus 88.1%. NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively. Multivariate analyses revealed that tumor location was not an independent prognostic factor ( = 0.081), but tumor size ( = 0.037) and pathological classification ( = 0.012) were independent prognostic factors. Conclusion. Significant differences exist between colonic and rectal NENs. Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis. Tumor location was not an independent factor. The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis.

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Gastroenteropancreatic neuroendocrine neoplasms: a 10-year experience of a single center

Cited by 25 publications

References 18 publications

A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms

A novel predictive model based on preoperative blood neutrophil-to-lymphocyte ratio for survival prognosis in patients with gastric neuroendocrine neoplasms

A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition

Clinicopathological features and prognostic factors of colorectal neuroendocrine neoplasms.

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