Gastroesophageal reflux disease and the relationship with Helicobacter pylori

Mungan, Zeynel; Simsek, Binnur

doi:10.5152/tjg.2017.16

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…Circadian clock disruption results in similar deleterious effects as the chronic inflammation induced by H. pylori [69]. However, no relationship between GERD and H. pylori was found [70]. H. pylori may be one of the causes of functional dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation

Shao

et al. 2019

EBioMedicine

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BackgroundRhythm abnormalities are crucial for diverse diseases. However, their role in disease progression induced by Helicobacter pylori (H. pylori) remains elusive.MethodsH. pylori infection was used in in vivo and in vitro experiments to examine its effect on rhythmic genes. The GEO database was used to screen H. pylori affecting rhythm genes, and the effect of rhythm genes on inflammatory factors. Chromatin immunoprecipitation and dual luciferase assays were used to further find out the regulation between molecules. Animal models were used to confirm the relationship between rhythm genes and H. pylori-induced inflammation.FindingsBMAL1 disorders aggravate inflammation induced by H. pylori. Specifically, H. pylori induce BMAL1 expression in vitro and in vivo through transcriptional activation of LIN28A, breaking the circadian rhythm. Mechanistically, LIN28A binds to the promoter region of BMAL1 and directly activates its transcription under H. pylori infection. BMAL1 in turn functions as a transcription factor and enhances the expression of proinflammatory cytokine TNF-α, thereby promoting inflammation. Of note, BMAL1 dysfunction in the rhythm disorder animal model aggravates inflammatory response induced by H. pylori infection in vivo.InterpretationThese findings in this study imply the pathogenic relationship between BMAL1 and H. pylori. BMAL1 may serve as a potential diagnostic marker and therapeutic target for the early diagnosis and treatment of diseases related to H. pylori infection.FundNational Natural Science Foundation of China.

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Section: Discussionmentioning

confidence: 99%

H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation

Shao

et al. 2019

EBioMedicine

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“…R.K. Rasane и соавт. [44] продемонстрировали, что пациенты с H P -отрицательными формами ЯБ имели более вы раж енную тяж есть течения забо левания и более негативный прогноз, чем лица с Н Р-ассоциированны м и формами. Так, показатель уровня альбумина в H P -негативной (HPN) группе бы л вы ш е, чем в Н Р -п ози ти вн ой группе (HPP): 3 .8 6 -0 .9 1 против 2 .9 7 -0 .9 6 , p=0.0001.…”

Section: H Pylori и язвенная болезнь (яб)unclassified

On the 40<sup>th</sup> anniversary of the discovery of Helicobacter pylori

Reshetnyak

Burmistrov

2022

jour

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The review is dedicated to the analysis of the accumulated data on the study of Helicobacter pylori (H. pylori) since the detailed description of this bacterium as the main etiological factor of gastrointestinal diseases. The work shows the dual role of H. pylori both as a bacterial pathogen for humans and as a potential representative of the normal microbiome of the stomach. In most scientific publications, the attention of researchers is focused entirely on the consideration of the pathogenic properties of H. pylori in the development of chronic gastritis, peptic ulcer disease (PUD) and gastric cancer (GC), and also considers the development of effective methods of eradication therapy. Along with this, in recent years, more and more often there are works that indicate a potentially positive effect of this bacterium on the human body and the occurrence of a number of negative consequences after eradication therapy. In this connection, the question of the probable affiliation of H. pylori to the composition of the human microbiome is discussed. Data on the high prevalence of the microorganism in the population and its asymptomatic coexistence with humans indicate the persistence of the bacterium in the body, most likely as a representative of the microbiome. The accumulated data on the effect of H. pylori on human health demonstrate a clear ambiguity of the problem. In this regard, it is important to answer the question whether it is necessary to create programs for mass eradication of H. pylori, or whether it is necessary to approach the implementation of eradication therapy in a more personalized way.

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“…3 Although H. pylori infection would have a protective effect against esophageal adenocarcinoma and Barrett’s esophagus; 4 H. pylori infection increases the risk for gastroesophageal reflux, peptic or duodenal ulcer, and colorectal and gastric cancers. 5-9 In addition, H. pylori infection is also associated with non-gastrointestinal disorders like diabetes, obesity, acute coronary syndrome, periodontitis, nonalcoholic fatty liver, Sjögren syndrome, systemic sclerosis, pre-eclampsia, and infertility. 10-20 Therefore, curbing the burden of these diseases requires targeted interventions to eradicate H. pylori infection.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and antibiotic resistance profile of Helicobacter pylori infection in Cameroon: a systematic review with meta-analysis

Ngnameko

Noubiap

Nemg

et al. 2021

Preprint

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ObjectivesAlthough global epidemiology of Helicobacter pylori (HP) infection is well characterized, country-specific figure is more accurate for context-specific tailored interventions. The aim was to determine the prevalence, factors associated with infection, antibiotic resistance profile, and genotypes of HP in Cameroon.DesignA systematic review with meta-analysis.ParticipantsPeople living in Cameroon regardless of their clinical profile.Data sources and synthesisObservational studies published in PubMed, EMBASE, African Index Medicus, African Journals Online, and Health Sciences and Diseases up to October 12th, 2020. Study selection, data extraction, and methodological quality assessment were done by two independent authors. Random-effect meta-analysis served to pool prevalence data.ResultsFifteen studies were included. None investigated the genotypes of HP. Among symptomatic patients, the most common used test, urea breath test on gastric biopsy, yielded a prevalence 57.8% (95% confidence interval (CI): 34.3-79.5) of HP infection. This prevalence significantly varied between 47.0% (95%CI: 43.0-51.0) for antigen test in stool samples and 71.2% (95%CI: 59.1-81.9) for Giemsa on gastric biopsy; p = 0.0006. One study in asymptomatic children reported the prevalence of 52.3% (95%CI: 44.9-59.6) using antigen test for stool samples. Among the six studies investigating factors associated with HP infection, one performed a multivariable model and identified being student as protective factor compared to being employed (Odds ratio: 0.09; 95%CI: 0.02–0.49). For antibiotics used for first line treatment, HP was resistant to amoxicillin (85.6-97.1%), metronidazole (93.2-97.9%), and clarithromycin (13.6-44.7%) as reported in two studies.LimitationData were from six of the ten regions of Cameroon, hindering the generalizability of the findings to the country.ConclusionThis study depicted a high prevalence of HP infection and a worrying resistance profile to first-line antibiotics. When waiting for well-conducted studies, updated guidelines are needed for clinical practice for first-line antibiotic treatment.RegistrationPROSPERO, CRD42020220084.Strengths and limitations of this studyNot all the 10 regions of the country were represented in this study, hindering the generalizability of the findings.We were not able to substantially investigate sources of heterogeneity in the prevalence of Helicobacter pylori infection due to scarcity of data.Evidence investigating factors associated with Helicobacter pylori infection are weak and there was scarcity on data exploring antibiotic resistance profile of Helicobacter pylori.This study is the first to provide an estimate of the epidemiology and resistance profile of Helicobacter pylori in Cameroon.

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Gastroesophageal reflux disease and the relationship with Helicobacter pylori

Cited by 13 publications

References 21 publications

H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation

H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation

On the 40<sup>th</sup> anniversary of the discovery of Helicobacter pylori

Epidemiology and antibiotic resistance profile of Helicobacter pylori infection in Cameroon: a systematic review with meta-analysis

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